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QTc interval and ventricular action potential prolongation in the Mecp2Null/+ murine model of Rett syndrome

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Article Biochemistry & Molecular Biology

Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome

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Summary: This study investigated the ECG and ventricular AP characteristics in the Mecp2(Null/Y) male murine RTT model and found QT and QRS prolongation, as well as increased AP duration and instability. It also revealed an increase in I-Na,I-Late in the RTT myocytes. The inhibitor GS-6615 showed potential as a treatment for QT prolongation in RTT. These findings are important for understanding and treating RTT.

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