期刊
CLINICAL OPHTHALMOLOGY
卷 16, 期 -, 页码 2797-2801出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OPTH.S381503
关键词
faricimab; treatment-resistant; diabetic macular edema; recalcitrance
This study retrospectively assessed the short-term outcomes of switching from intravitreal aflibercept (IVA) to intravitreal faricimab (IVF) in treatment-resistant diabetic macular edema (DME) patients. The results showed that IVF can improve the visual and anatomical outcomes in a significant minority of DME patients who were previously managed with IVA. Longer follow-up is needed to determine if these improvements can be maintained.
Purpose: To assess the short-term outcomes in treatment-resistant diabetic macular edema (DME) patients changed from intravitreal aflibercept (IVA) to intravitreal faricimab (IVF).Methods: A retrospective review was undertaken on DME subjects receiving IVA therapy at a single private practice. Patients were separated into study and control cohorts. Both study and control patients had received more than or equal to six IVA injections during the preceding 12 months, more than or equal to four IVA injections during the preceding 6 months, had a central macular thickness (CMT) on optical coherence tomography (OCT) of >= 300 mu m, and had retinal fluid on OCT before cohort assignment. Study patients were switched to IVF and underwent three injections within 4 months, whereas control patients stayed on IVA during the same period and received three injections within 4 months.Results: There were 51 patients analyzed. There were 37.5% (9/24) in the study group and 3.7% (1/27) in the control group who achieved a CMT of less than 300 mu m without retinal fluid on OCT at the end of the 4-month study (p=0.001). There were 41.7% (10/24) in the study group and 11.1% (3/27) in the control group who had gained two or more lines of visual acuity at the end of the 4-month study (p=0.01). Conclusion: For a significant minority, IVF can improve the short-term visual and anatomic outcomes in treatment-resistant DME patients formerly managed with IVA. Longer follow-up is needed to determine if such improvements can be preserved.
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