Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases

The present study aimed to design functional fermented goat milk with probiotic potential for metabolic diseases. Thereby, autochthonous lactobacilli from goat dairy products that target improving the inflammatory, lipid, and glycemic profile were characterized. We designed fermented goat milk using Lactobacillus delbrueckii subsp. indicus CRL1447 as starter strain, supplemented with different probiotic consortia formed by Limosilactobacillus fermen-tum CRL1446, Lactiplantibacillus paraplantarum CRL1449, and CRL1472 strains. These lactobacilli were selected for their positive effects on inhibition of alpha-glucosidase, bile salts hydrolase activity, cholesterol assimilation, and decreased triglyceride percentage in Caenorhabditis elegans. Furthermore, the lactobacilli oral administration to obese mice caused a significant decrease in body weight gain and ameliorated hyperglycemia and hyperlipemia. These results reveal the potential of this goat dairy product as a functional food to prevent obesity and related pathologies. Goat milk-derived products stand out for their marketing potential. Hence, fermented goat milk incorporating novel probiotics represents a group of food products with broad prospects by their promising nutritive and therapeutic properties for metabolic diseases. The goat dairy product designed in this study could be used in the prevention of dyslipidemia and hyperglycemia in obese people.

Automated summary

This study aimed to design functional fermented goat milk with probiotic potential for metabolic diseases. The researchers characterized indigenous lactobacilli from goat dairy products that target improving the inflammatory, lipid, and glycemic profile. Fermented goat milk incorporating these lactobacilli showed positive effects on inhibiting alpha-glucosidase, bile salts hydrolase activity, cholesterol assimilation, and reducing triglyceride percentage. The oral administration of these lactobacilli to obese mice resulted in significant weight loss and improved hyperglycemia and hyperlipemia.