4.5 Article

Higher Sensory Sensitivity is Linked to Greater Expansion Amongst Functional Connectivity Gradients

出版社

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-022-05772-z

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Autism spectrum disorders; Sensory sensitivity; fMRI; Functional connectivity

资金

  1. Leverhulme Trust [DS-2017-011]

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This study investigates individual differences in cortical organization related to autistic-like traits and finds a principal gradient reflecting the transition from perception to abstract cognition. The expansion of this gradient is correlated with subjective sensory sensitivity, indicating that sensory issues can be disentangled from the wider autistic-like phenotype.
Insofar as the autistic-like phenotype presents in the general population, it consists of partially dissociable traits, such as social and sensory issues. Here, we investigate individual differences in cortical organisation related to autistic-like traits. Connectome gradient decomposition based on resting state fMRI data reliably reveals a principal gradient spanning from unimodal to transmodal regions, reflecting the transition from perception to abstract cognition. In our non-clinical sample, this gradient's expansion, indicating less integration between visual and default mode networks, correlates with subjective sensory sensitivity (measured using the Glasgow Sensory Questionnaire, GSQ), but not other autistic-like traits (measured using the Autism Spectrum Quotient, AQ). This novel brain-based correlate of the GSQ demonstrates sensory issues can be disentangled from the wider autistic-like phenotype.

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