期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 53, 期 12, 页码 4830-4848出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-022-05767-w
关键词
Autism spectrum disorder; Brain oscillations; Preferred phase angle; MEG; Classification; Biomarker
This study aimed to find biomarkers of autism in young children. By recording magnetoencephalography (MEG), unique patterns of neural oscillations were discovered in children with autism, providing novel insights into the pathophysiology of autism.
In this study, we aimed to find biomarkers of autism in young children. We recorded magnetoencephalography (MEG) in thirty children (4-7 years) with autism and thirty age, gender-matched controls while they were watching cartoons. We focused on characterizing neural oscillations by amplitude (power spectral density, PSD) and phase (preferred phase angle, PPA). Machine learning based classifier showed a higher classification accuracy (88%) for PPA features than PSD features (82%). Further, by a novel fusion method combining PSD and PPA features, we achieved an average classification accuracy of 94% and 98% for feature-level and score-level fusion, respectively. These findings reveal discriminatory patterns of neural oscillations of autism in young children and provide novel insight into autism pathophysiology.
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