期刊
INTERNATIONAL JOURNAL OF BIOPRINTING
卷 8, 期 4, 页码 254-273出版社
WHIOCE PUBL PTE LTD
DOI: 10.18063/ijb.v8i4.617
关键词
3D printing; Modular design; Microextrusion; Multifunctional printing
资金
- National Key Research and Development Program of China [2018YFA0703004]
Three-dimensional bioprinting has the potential to reverse engineer human pathophysiology and develop biomimetic experimental systems. This study presents a portable, modular, low-cost, and easy-to-use multifunctional 3D bioprinting system that can successfully print constructs with detailed surface structures, hollow structures, and multiscale complex tissue analogs.
Three-dimensional (3D) bioprinting offers a potentially powerful new approach to reverse engineering human pathophysiology to address the problem of developing more biomimetic experimental systems. Human tissues and organs are multiscale and multi-material structures. The greatest challenge for organ printing is the complexity of the structural elements, from the shape of the macroscopic structure to the details of the nanostructure. A highly bionic tissue-organ model requires the use of multiple printing processes. Some printers with multiple nozzles and multiple processes are currently reported. However, the bulk volume, which is inconvenient to move, and the high cost of these printing systems limits the expansion of their applications. Scientists urgently need a multifunctional miniaturized 3D bioprinter. In this study, a portable multifunctional 3D bioprinting system was built based on a modular design and a custom written operating application. Using this platform, constructs with detailed surface structures, hollow structures, and multiscale complex tissue analogs were successfully printed using commercial polymers and a series of hydrogel-based inks. With further development, this portable, modular, low-cost, and easy-to-use Bluetooth-enabled 3D printer promises exciting opportunities for resource-constrained application scenarios, not only in biomedical engineering but also in the education field, and may be used in space experiments.
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