期刊
LANCET RHEUMATOLOGY
卷 4, 期 12, 页码 E853-E863出版社
ELSEVIER
DOI: 10.1016/S2665-9913(22)00305-8
关键词
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资金
- Versus Arthritis and Pfizer Global Medical Grants for Quality Improvement in Rheumatology Practice [68033839]
- National Institute for Health Research (NIHR) Doctoral Fellowship [NIHR300967]
- UK Research and Innovation [MC_PC_20058]
- Wellcome Trust
- MRC [MR/V015757/1, MC_PC-20059, MR/W016729/1]
- NIHR [NIHR135559, COV-LT2-0073]
- Health Data Research UK [HDRUK2021.000, 2021.0157]
- Bennett Foundation
- NIHR Oxford Biomedical Research Centre
- NIHR Applied Research Collaboration Oxford
- NHS England Transformation Directorate
- North East Commissioning Support Unit
- National Institutes of Health Research (NIHR) [NIHR135559, COV-LT2-0073, NIHR300967] Funding Source: National Institutes of Health Research (NIHR)
The impact of the COVID-19 pandemic on the incidence and management of inflammatory arthritis was analyzed using data from OpenSAFELY. The study found that the number of new inflammatory arthritis diagnoses decreased during the pandemic, but there was a smaller impact on rheumatology assessment times and DMARD prescribing in primary care than expected.
Background The impact of the COVID-19 pandemic on the incidence and management of inflammatory arthritis is not understood. Routinely captured data in secure platforms, such as OpenSAFELY, offer unique opportunities to understand how care for patients with inflammatory arthritis was impacted upon by the pandemic. Our objective was to use OpenSAFELY to assess the effects of the pandemic on diagnostic incidence and care delivery for inflammatory arthritis in England and to replicate key metrics from the National Early Inflammatory Arthritis Audit. Methods In this population-level cohort study, we used primary care and hospital data for 17 center dot 7 million adults registered with general practices using TPP health record software, to explore the following outcomes between April 1, 2019, and March 31, 2022: (1) incidence of inflammatory arthritis diagnoses (rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and undifferentiated inflammatory arthritis) recorded in primary care; (2) time to first rheumatology assessment; (3) time to first prescription of a disease-modifying antirheumatic drug (DMARD) in primary care; and (4) choice of first DMARD. Findings Among 17 683 500 adults, there were 31 280 incident inflammatory arthritis diagnoses recorded between April 1, 2019, and March 31, 2022. The mean age of diagnosed patients was 55 center dot 4 years (SD 16 center dot 6), 18 615 (59 center dot 5%) were female, 12 665 (40 center dot 5%) were male, and 22 925 (88 center dot 3%) of 25 960 with available ethnicity data were White. New inflammatory arthritis diagnoses decreased by 20 center dot 3% in the year commencing April, 2020, relative to the preceding year (5 center dot 1 vs 6 center dot 4 diagnoses per 10 000 adults). The median time to first rheumatology assessment was shorter during the pandemic (18 days; IQR 8-35) than before (21 days; 9-41). The proportion of patients prescribed DMARDs in primary care was similar before and during the pandemic; however, during the pandemic, fewer people were prescribed methotrexate or leflunomide, and more were prescribed sulfasalazine or hydroxychloroquine. Interpretation Inflammatory arthritis diagnoses decreased markedly during the early phase of the pandemic. The impact on rheumatology assessment times and DMARD prescribing in primary care was less marked than might have been anticipated. This study demonstrates the feasibility of using routinely captured, near real-time data in the secure OpenSAFELY platform to benchmark care quality on a national scale, without the need for manual data collection.
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