期刊
MATERIALS TODAY CHEMISTRY
卷 25, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mtchem.2022.100968
关键词
Hemostasis; Antibacterial materials; Antioxidant; Polyphenol; Polysaccharide
资金
- National Natural Science Foundation of China [21872085, 82073437]
- Innovation Project of Jinan Science and Technology Bureau [2020GXRC022]
- Natural Science Foundation of Shandong Province [ZR2019BB056]
- Translational Medicine Core Facility of Advanced Medical Research Institute at Shandong University
A reductionism approach was used to fabricate bioactive hydrogels with antibacterial, antioxidant, pro-angiogenic and hemostatic properties. The hydrogels composed of Cirsium setosum extracts and carboxymethyl chitosan showed potential for surgical anti-infections in different models.
Surgical procedures are susceptible to the cause of infections, which could induce delayed wound healing, oxidative stress and tissue ischemia. Multifunctional wound dressings (e.g., hydrogels) without the induction of antibiotics is promising for the elimination of surgical site infections and the associated complications. Herein, we report a reductionism approach for the fabrication of bioactive hydrogels to recapitulate antibacterial functions as well as antioxidant, pro-angiogenic and hemostatic properties in surgical infection treatments. The hydrogels composed of naturally derived Cirsium setosum extracts (CE, a traditional medicinal herb) and carboxymethyl chitosan (CS) show their capacity for surgical antiinfections on three different models (i.e., infectious random skin flap model, infectious skin defect model and infectious femur fracture model). Due to the innate bioactivities of CE and CS, CECS hydrogels can also reduce the bleeding loss (85% reduction) on a hemorrhaging liver model and improve the vascularization for skin flap regeneration. Overall, bioactive CECS hydrogels integrated with the ease and scalability of assembly process and biological activities without the addition of antibiotics is promising to act as multifunctional wound dressings for surgical anti-infections. (c) 2022 Elsevier Ltd. All rights reserved.
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