Gelatin-Based Injectable Hydrogel/Microgel Composite as a Combinational Dual Drug Delivery System for Local Co-delivery of Curcumin and 5-Fluorouracil in Synergistic Therapy of Colorectal Cancer br

Review Biochemistry & Molecular Biology

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

Maleki Parisa Dana et al.

Summary: Polyphenols, natural compounds with beneficial properties, can increase the sensitivity of cancer cells to chemotherapeutic agents and affect other mechanisms for overcoming chemoresistance in cancer cells.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Biology

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment

Shamin Azwar et al.

Summary: Chemotherapy resistance in cancer cells, particularly to 5-FU, is a major factor contributing to treatment failure, with various mechanisms and pathways identified for this resistance. Efforts are ongoing to prevent and reverse this resistance, aiming to enhance the antitumor effects of 5-FU and improve overall survival for patients.

BIOLOGY-BASEL (2021)

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Article Engineering, Environmental

Novel supramolecular self-healing silk fibroin-based hydrogel via host-guest interaction as wound dressing to enhance wound healing

Rui Yu et al.

Summary: A novel self-healing SF-based hydrogel was developed through dual crosslinking for enhanced wound dressing performance and as a drug carrier with controlled release, showing great potential in wound healing.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Advances in biodegradable and injectable hydrogels for biomedical applications

Yi Li et al.

Summary: In situ-forming injectable hydrogels are smart biomaterials with great potential in various biomedical applications, including drug/protein/gene delivery, tissue engineering, and regenerative medicine. These hydrogels can be injected into living bodies at room temperature, gradually degrade over time, and release active substances.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Nanoscience & Nanotechnology

Targeted drug delivery strategies for precision medicines

Mandana T. Manzari et al.

Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.

NATURE REVIEWS MATERIALS (2021)

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Review Medicine, Research & Experimental

5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition

Chinmayee Sethy et al.

Summary: 5-Fluorouracil (5-FU) is a crucial anti-cancer drug, but drug resistance has hindered its clinical efficacy. Overcoming chemoresistance, especially caused by cancer stem cells, remains a challenge.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Plant Sciences

Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer

Xiaochun Zheng et al.

Summary: The study demonstrated a synergistic effect of curcumin in combination with 5-FU on inhibiting proliferation and migration, increasing apoptosis rate, and extending survival in CRC cells. Curcumin enhanced chemosensitivity of CRC cells to 5-FU by downregulating L1 expression. This combination therapy could potentially reduce the toxicity and adverse effects of 5-FU in clinical applications.

PHYTOMEDICINE (2021)

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Article Polymer Science

Local co-delivery of 5-fluorouracil and curcumin using Schiff's base cross-linked injectable hydrogels for colorectal cancer combination therapy

Hamid Sadeghi-Abandansari et al.

Summary: A novel hydrogel was developed for the simultaneous administration of two drugs with different hydrophilicity, 5-FU and curcumin. In vitro experiments demonstrated the sustained release of both drugs and enhanced anticancer effects of the combination therapy in colon cancer cells.

EUROPEAN POLYMER JOURNAL (2021)

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Review Biochemistry & Molecular Biology

The Role of Curcumin in Cancer Treatment

Vasiliki Zoi et al.

Summary: Curcumin, a polyphenol extracted from turmeric, has anti-inflammatory and anticancer properties by regulating immune modulators and signaling pathways. Clinical trials have shown its effectiveness in various types of cancer.

BIOMEDICINES (2021)

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Article Medicine, Research & Experimental

Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels

Baojun Chen et al.

Summary: A composite hydrogel was developed for promoting rotator cuff tendon-to-bone healing through sustained release of curcumin and Mg2+, demonstrating significant anti-inflammatory and pro-differentiation effects. The hydrogel exhibited excellent biocompatibility and injectability, and enhanced tendon-to-bone healing in a rat model of rotator cuff tear at 8 weeks post-surgery.

THERANOSTICS (2021)

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Review Pharmacology & Pharmacy

Combination Therapies and Drug Delivery Platforms in Combating Pancreatic Cancer

Fan Lei et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

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Article Nanoscience & Nanotechnology

Dual Stimuli-Triggered Nanogels in Response to Temperature and pH Changes for Controlled Drug Release

Yun Kyoung Kim et al.

NANOSCALE RESEARCH LETTERS (2019)

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Review Biochemistry & Molecular Biology

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Junpeng Xu et al.

MOLECULES (2019)

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Article Integrative & Complementary Medicine

Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein

Wen-ting He et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2019)

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Article Biochemical Research Methods

Predictive approaches for drug combination discovery in cancer

Seyed Ali Madani Tonekaboni et al.

BRIEFINGS IN BIOINFORMATICS (2018)

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Article Nanoscience & Nanotechnology

Nanogel-Incorporated Injectable Hydrogel for Synergistic Therapy Based on Sequential Local Delivery of Combretastatin-A4 Phosphate (CA4P) and Doxorubicin (DOX)

Wen Jing Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Biochemistry & Molecular Biology

Injectable Hydrogel with Slow Degradability Composed of Gelatin and Hyaluronic Acid Cross-Linked by Schiff's Base Formation

Takuro Hozumi et al.

BIOMACROMOLECULES (2018)

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Article Engineering, Biomedical

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Jin Qu et al.

BIOMATERIALS (2018)

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Review Engineering, Biomedical

Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications

Eneko Larraneta et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2018)

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Review Biochemistry & Molecular Biology

Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer

Ines Marmol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Polymer Science

Click functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems

Wen Jing Yang et al.

POLYMER CHEMISTRY (2017)

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Review Materials Science, Multidisciplinary

Gelatin-based hydrogels for biomedical applications

Panupong Jaipan et al.

MRS COMMUNICATIONS (2017)

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Article Oncology

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer

Shusuke Toden et al.

CARCINOGENESIS (2015)

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Article Chemistry, Medicinal

Curcumin Reduces Cytotoxicity of 5-Fluorouracil Treatment in Human Breast Cancer Cells

Jeannette E. Ferguson et al.

JOURNAL OF MEDICINAL FOOD (2015)

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Review Polymer Science

Mussel-inspired hydrogels for biomedical and environmental applications

Lin Li et al.

POLYMER CHEMISTRY (2015)

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Editorial Material Multidisciplinary Sciences

BIOLOGY Three known unknowns

Katherine Bourzac

NATURE (2014)

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Article Engineering, Biomedical

Rapid engineering of endothelial cell-lined vascular-like structures in in situ crosslinkable hydrogels

Tatsuto Kageyama et al.

BIOFABRICATION (2014)

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Article Chemistry, Multidisciplinary

Injectable alginate microsphere/PLGA-PEG-PLGA composite hydrogels for sustained drug release

Jun Zhao et al.

RSC ADVANCES (2014)

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Article Materials Science, Multidisciplinary

Free-standing poly (N-isopropylacrylamide) microgel-based etalons

Yongfeng Gao et al.

JOURNAL OF MATERIALS CHEMISTRY C (2014)

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Review Pharmacology & Pharmacy

Block copolymer micelles for drug delivery: Design, characterization and biological significance

Kazunori Kataoka et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Review Chemistry, Physical

Shear-thinning hydrogels for biomedical applications

Murat Guvendiren et al.

SOFT MATTER (2012)

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Article Biochemistry & Molecular Biology

Injectable Microgel-Hydrogel Composites for Prolonged Small-Molecule Drug Delivery

Daryl Sivakumaran et al.

BIOMACROMOLECULES (2011)

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Article Biophysics

Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system

Qihe Gao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2011)

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Article Chemistry, Multidisciplinary

Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo

MaLing Gou et al.

NANOSCALE (2011)

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Article Chemistry, Physical

Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs

Li Liu et al.

SOFT MATTER (2011)

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Article Biochemistry & Molecular Biology

Injectable Microsphere/Hydrogel Combination Systems for Localized Protein Delivery

Jangwook Lee et al.

MACROMOLECULAR BIOSCIENCE (2009)

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Article Pharmacology & Pharmacy

Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro

Lorena Rossi et al.

PHARMACOLOGICAL RESEARCH (2007)

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Article Pharmacology & Pharmacy

Controlled release of doxorubicin from thermosensitive poly(organophosphazene) hydrogels

Gyung D. Kang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

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Article Engineering, Biomedical

Controlled release of bioactive TGF-β1 from microspheres embedded within biodegradable hydrogels

AJ DeFail et al.

BIOMATERIALS (2006)

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Article Oncology

Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29

BY Du et al.

CHEMOTHERAPY (2006)

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Article Oncology

Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: A multi-institutional study

O Glehen et al.

JOURNAL OF CLINICAL ONCOLOGY (2004)

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Review Oncology

5-Fluorouracil: Mechanisms of action and clinical strategies

DB Longley et al.

NATURE REVIEWS CANCER (2003)

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Article Oncology

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

SE Chuang et al.

CARCINOGENESIS (2000)

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Gelatin-Based Injectable Hydrogel/Microgel Composite as a Combinational Dual Drug Delivery System for Local Co-delivery of Curcumin and 5-Fluorouracil in Synergistic Therapy of Colorectal Cancer br

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