Multiscale Magnetic Hydrogel Robot with a Core-Shell Structure for Active Targeted Delivery

Article Chemistry, Multidisciplinary

Magnetic Microswarm and Fluoroscopy-Guided Platform for Biofilm Eradication in Biliary Stents

Mengmeng Sun et al.

Summary: Treating biofilm infections on medical implants is challenging, but magnetically driven microrobots show potential for disrupting these harmful biostructures.

ADVANCED MATERIALS (2022)

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Review Biochemistry & Molecular Biology

Recent advances of chitosan-based nanoparticles for biomedical and biotechnological applications

Yanyun Gao et al.

Summary: Chitosan is a natural alkaline polysaccharide with various biological activities and excellent properties, such as biocompatibility, biodegradability, non-toxicity, and easy access. Different functional groups can be introduced into chitosan molecules through molecular or chemical modification, expanding their applications. Chitosan-based nanoparticles have important applications in biomedicine and other fields.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Chemistry, Medicinal

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

Paola Mura et al.

Summary: Chitosan (CS) is a polysaccharide that is obtained from the deacetylation of chitin, making it the second most abundant biopolymer in nature after cellulose. It has attracted great interest in the pharmaceutical field due to its various beneficial features, including biocompatibility, biodegradability, non-toxicity, and simplicity of chemical modifications. CS is capable of forming films, hydrogels, and micro- and nanoparticles, and its cationic character allows for strong interactions with different molecules and exhibits antimicrobial, anti-inflammatory, and hemostatic activities. However, its solubility is pH-dependent and it is susceptible to ions, which may pose challenges. Currently, CS and its derivatives are widely investigated for pharmaceutical applications, particularly in mucosal drug delivery.

MARINE DRUGS (2022)

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Review Chemistry, Applied

Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease

Nilesh Kulkarni et al.

Summary: Chitosan, a cationic polymer with biodegradability, is a suitable choice for colon-targeted drug delivery in inflammatory bowel disease. Its ability to attach strongly to mucosa and interact with anionic polymers enables safe and efficient delivery to the colon. Compared to commercial grade gastro-resistant polymers, chitosan is considered safer for long-term therapy in chronic diseases.

CARBOHYDRATE POLYMERS (2022)

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Article Materials Science, Multidisciplinary

Nanofiber-based biodegradable millirobot with controllable anchoring and adaptive stepwise release functions

Rong Tan et al.

Summary: This study presents a degradable millirobot based on nanofibers that can work in the alimentary tract. The robot can programmatically release different drugs in response to variations in acidic physiological concentrations. The multi-legged design allows effective locomotion in harsh in-body environments. In a rabbit model, the robot demonstrated locomotion abilities, desired-region anchoring, and stepwise drug release.

MATTER (2022)

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Review Pharmacology & Pharmacy

Liposomal doxorubicin as targeted delivery platform: Current trends in surface functionalization

Vivek Makwana et al.

Summary: Liposomal delivery systems have greatly improved the efficacy and safety of chemotherapeutic agents, particularly in the case of doxorubicin. Surface modification of liposomes, such as pegylation, can prolong drug circulation time and enhance drug accumulation in tumor tissue through passive targeting. Active targeting using biological ligands on the liposome surface shows potential for further improving tumor targeting efficiency in drug delivery systems.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents

Junhee Choi et al.

Summary: Magnetically actuated microrobots have made significant progress in targeted therapeutic delivery, offering unique advantages in accessing hard-to-reach lesions in a minimally invasive manner. However, challenges such as low survival rate of transplanted cells and difficulties with administration route remain to be addressed for further advancements in the field.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells

Fatemeh Abedi et al.

Summary: The proposed combination therapy using smart responsive nanogels can achieve a synergistic effect for cancer treatment, reduce drug dosage, and improve efficacy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination for Synergistic Chemotherapy

Fangzhou Yu et al.

Summary: An innovative dual-drug delivery system was designed in this study to achieve precise drug release ratios and generate synergistic anticancer effects.

NANO LETTERS (2021)

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Article Multidisciplinary Sciences

A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

Yanmei He et al.

Summary: By developing cascade-targeting, dual drug-loaded core-shell nanoparticles, precise drug delivery to tumors and overcoming biological barriers were achieved; the degradation of hyaluronic acid shell facilitated drug release and cellular uptake, while the exposure of triphenylphosphonium derivative core allowed for mitochondria-targeted delivery, ultimately inhibiting tumor growth.

SCIENCE ADVANCES (2021)

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Review Chemistry, Multidisciplinary

Magnetically Driven Micro and Nanorobots

Huaijuan Zhou et al.

Summary: Magnetic micro/nanorobots can be manipulated and guided in different fluid environments using magnetic fields, offering advantages such as remote control, reconfigurability, and fuel-free operation. They have diverse applications in targeted drug delivery, biofilm disruption, and environmental remediation.

CHEMICAL REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Transport and Assembly of Magnetic Surface Rotors**

Pietro Tierno et al.

Summary: This minireview discusses recent advancements in surface magnetic rotors, which can be remotely spun, steered, interaction-tuned, and assembled using external magnetic modulations. These microscopic wheels have potential applications in microfluidic devices, drug delivery, mixing, and as model systems for biological active matter research. Optically monitoring these dissipative colloidal systems can reveal complex collective phenomena under the influence of external fields.

CHEMNANOMAT (2021)

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Review Nanoscience & Nanotechnology

Multifunctional biomolecule nanostructures for cancer therapy

Jing Wang et al.

Summary: This review discusses the application of biomolecule-based nanostructures in smart cancer nanomedicine. These multifunctional nanostructures, including polysaccharides, nucleic acids, peptides, and proteins, can achieve targeted drug delivery and transport drugs to tumor tissues.

NATURE REVIEWS MATERIALS (2021)

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Review Medicine, Research & Experimental

A comprehensive review on time-tested anticancer drug doxorubicin

Sruthi Sritharan et al.

Summary: Doxorubicin is a widely used chemotherapeutic drug for cancer treatment, inducing cell death through various mechanisms and aiding in immune clearance of tumor cells, but its applicability is limited by the development of chemoresistance and cardiotoxicity. Various formulations and co-treatments are essential in reducing toxicity and combating resistance. Further research into the molecular mechanisms of chemoresistance development is crucial for improving patient survivability and preventing cancer relapse.

LIFE SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Immunostimulatory photochemotherapeutic nanocapsule for enhanced colon cancer treatment

Jie Liu et al.

Summary: This research developed a novel core/shell-structured polydopamine (PDA)-based nanoplatform to load two FDA-approved cytotoxic drugs, achieving immunostimulatory photochemotherapy for colon cancer and successfully preventing tumor recurrence.

NANOPHOTONICS (2021)

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Review Pharmacology & Pharmacy

Alginate and alginate composites for biomedical applications

Raha Ahmad Raus et al.

Summary: Alginate is an edible heteropolysaccharide widely used in food, textile, and paper industries, as well as in biomedical applications for wound healing and tissue regeneration. To overcome the limitations of alginate, various materials have been added to create sturdy composite materials with improved mechanical properties, healing capability, and tissue regeneration promotion.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Applied

Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

Chinnaiyan Senthil Kumar et al.

CARBOHYDRATE POLYMERS (2020)

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Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Materials Science, Multidisciplinary

Polymeric microellipsoids with programmed magnetic anisotropy for controlled rotation using low (≈10 mT) magnetic fields

Andrea Bonilla-Brunner et al.

APPLIED MATERIALS TODAY (2020)

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Article Chemistry, Multidisciplinary

Autonomous Biohybrid Urchin-Like Microperforator for Intracellular Payload Delivery

Mengmeng Sun et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels Through a Transversal Rotating Magnetic Field

Jan Vyskocil et al.

ACS NANO (2020)

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Review Chemistry, Multidisciplinary

Fantastic Voyage of Nanomotors into the Cell

Pooyath Lekshmy Venugopalan et al.

ACS NANO (2020)

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Review Pharmacology & Pharmacy

Micro/Nanorobot: A Promising Targeted Drug Delivery System

Mengyi Hu et al.

PHARMACEUTICS (2020)

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Article Materials Science, Multidisciplinary

Magnetic/pH-sensitive double-layer microrobots for drug delivery and sustained release

Weinan Chen et al.

APPLIED MATERIALS TODAY (2020)

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Article Multidisciplinary Sciences

Light-steered locomotion of muscle-like hydrogel by self-coordinated shape change and friction modulation

Qing Li Zhu et al.

NATURE COMMUNICATIONS (2020)

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Review Chemistry, Multidisciplinary

Doxorubicin-loaded composite nanogels for cancer treatment

Marzieh Mohammadi et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Multidisciplinary Sciences

Engineering microrobots for targeted cancer therapies from a medical perspective

Christine K. Schmidt et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Reconfigurable multifunctional ferrofluid droplet robots

Xinjian Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Multidisciplinary Sciences

The electrochemical fabrication of hydrogels: a short review

Emily R. Cross

SN APPLIED SCIENCES (2020)

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Review Cell Biology

Chitosan-based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects

Mahsa Saheb et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Chemistry, Physical

pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery

Yongping Liang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Review Pharmacology & Pharmacy

Curcumin Nanoformulations for Colorectal Cancer: A Review

Kar En Wong et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Chemistry, Multidisciplinary

MOFBOTS: Metal-Organic-Framework-Based Biomedical Microrobots

Xiaopu Wang et al.

ADVANCED MATERIALS (2019)

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Article Multidisciplinary Sciences

Tunable self-healing of magnetically propelling colloidal carpets

Helena Massana-Cid et al.

NATURE COMMUNICATIONS (2019)

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Article Materials Science, Biomaterials

On-Demand Radial Electrodeposition of Alginate Tubular Structures

David M. Kingsley et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Robotics

Millimeter-scale flexible robots with programmable three-dimensional magnetization and motions

Tianqi Xu et al.

SCIENCE ROBOTICS (2019)

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Review Engineering, Biomedical

Theranostic designs of biomaterials for precision medicine in cancer therapy

Hyosuk Kim et al.

BIOMATERIALS (2019)

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Article Biophysics

Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin

Jian-Tao Lin et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Instruments & Instrumentation

Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment

Alina Sesarman et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2019)

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Article Multidisciplinary Sciences

Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins

Yabin Zhang et al.

SCIENCE ADVANCES (2019)

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Article Chemistry, Multidisciplinary

3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release

Hakan Ceylan et al.

ACS NANO (2019)

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Review Pharmacology & Pharmacy

Polymeric nanoparticles as carrier for targeted and controlled delivery of anticancer agents

Vahid Taghipour-Sabzevar et al.

THERAPEUTIC DELIVERY (2019)

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Article Robotics

Reconfigurable magnetic microrobot swarm: Multimode transformation, locomotion, and manipulation

Hui Xie et al.

SCIENCE ROBOTICS (2019)

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Article Chemistry, Multidisciplinary

Small-Scale Machines Driven by External Power Sources

Xiang-Zhong Chen et al.

ADVANCED MATERIALS (2018)

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Review Biochemistry & Molecular Biology

Chitosan as biomaterial in drug delivery and tissue engineering

Saad M. Ahsan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Chemistry, Multidisciplinary

Self-Propelled Nanomotors for Thermomechanically Percolating Cell Membranes

Mingjun Xuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Chemistry, Multidisciplinary

Enhanced Removal of Toxic Heavy Metals Using Swarming Biohybrid Adsorbents

Yabin Zhang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Codelivery of Hydrophobic and Hydrophilic Drugs by Graphene-Decorated Magnetic Dendrimers

Ali Pourjavadi et al.

LANGMUIR (2018)

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Article Robotics

Development of a magnetic microrobot for carrying and delivering targeted cells

Junyang Li et al.

SCIENCE ROBOTICS (2018)

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Article Pharmacology & Pharmacy

Enhanced Intestinal Permeation of Doxorubicin Using Chitosan Nanoparticles

Marziyeh Zare et al.

ADVANCED PHARMACEUTICAL BULLETIN (2018)

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Article Engineering, Biomedical

Hybrid 3D printing and electrodeposition approach for controllable 3D alginate hydrogel formation

Wanfeng Shang et al.

BIOFABRICATION (2017)

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Article Chemistry, Multidisciplinary

Artificial Swimmers Propelled by Acoustically Activated Flagella

Daniel Ahmed et al.

NANO LETTERS (2016)

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Review Oncology

A Systematic Review of Adherence to Oral Antineoplastic Therapies

Joseph A. Greer et al.

ONCOLOGIST (2016)

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Review Chemistry, Multidisciplinary

Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

Nohyun Lee et al.

CHEMICAL REVIEWS (2015)

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Review Microbiology

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

Imen Kahouli et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2013)

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Article Chemistry, Multidisciplinary

Controlled Propulsion and Cargo Transport of Rotating Nickel Nanowires near a Patterned Solid Surface

Li Zhang et al.

ACS NANO (2010)

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Article Chemistry, Applied

Novel interpenetrating polymer network microspheres of chitosan and methylcellulose for controlled release of theophylline

Ajit P. Rokhade et al.

CARBOHYDRATE POLYMERS (2007)

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Multiscale Magnetic Hydrogel Robot with a Core-Shell Structure for Active Targeted Delivery

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