4.7 Article

Curcumin/Zeolitic Imidazolate Framework-8 Nanoparticle-Integrated Microneedles for pH-Responsive Treatment of Skin Disorders

期刊

ACS APPLIED NANO MATERIALS
卷 5, 期 9, 页码 13671-13679

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsanm.2c03884

关键词

ZIF-8; curcumin; pH-responsive; microneedle; release; skin

资金

  1. National Research Foundation of Korea (NRF) - Korea government (MSIT) [2022R1A2C2003072]
  2. National Research Foundation of Korea [2022R1A2C2003072] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

A feasible strategy of on-demand drug delivery for dermal inflammation treatment under low-pH conditions is proposed. Zeolitic imidazolate framework-8 (ZIF-8) is used as a pH-responsive nanoparticle and curcumin (CCM) as a model drug. The drug is embedded in acid-degradable ZIF-8 nanoparticles and incorporated into water-dissolvable microneedles. In vitro tests demonstrate the pH-responsive drug release ability, high biocompatibility, and biodegradability of ZIF-8.
A feasible strategy of on-demand drug delivery for the treatment of dermal inflammation under low-pH conditions is proposed, employing zeolitic imidazolate framework-8 (ZIF-8) as a pH-responsive nanoparticle and curcumin (CCM) as a model drug. To overcome the low bioavailability of topically treated drug, a microneedle (MN) form is used to incorporate CCM and ZIF-8. Taking advantage of the fact that ZIF-8 degrades under acidic conditions, CCM is embedded in porous ZIF-8 nanoparticles such that CCM is released when ZIF-8 comes into contact with an acidic dermal fluid at the inflammation site, and this CCM-encapsulated ZIF-8 (CCMZIF) is incorporated into water-dissolvable poly(vinyl pyrrolidone) MN. The ZIF-8 shows a high loading capacity (similar to 40.5%) of CCM through chemical bonding and physical adsorption. From in vitro tests with both a buffered solution and porcine skin, CCM from the CCMZIF MN is released in a higher amount at pH 5.0 than at pH 7.4, demonstrating the capability of the pH-responsive release of the drug when needed at inflammatory sites. The analytical investigation conducted here reveals that an acidic environment triggers the structural degradation of ZIF-8, allowing the release of the chemically bonded CCM. Cytotoxicity and stability tests demonstrate the good biocompatibility and bioavailability of ZIF-8. This study highlights the analytical discussion of the encapsulation and release mechanism of CCM in a ZIF-8-implemented MN drug delivery platform. The results demonstrate an advanced on-demand therapeutic strategy for skin disorder treatment.

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