4.3 Article

Successful Treatment of a Patient with Pyoderma Gangrenosum, Plaque Psoriasis and Palmoplantar Pustulosis with Adalimumab

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出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/CCID.S373115

关键词

adalimumab; autoinflammatory syndrome; palmoplantar pustulosis; plaque psoriasis; pyoderma gangrenosum

资金

  1. National Natural Science Foundation of China [82173400, 81972931]
  2. Medical and Health Science and Technology Project of Health Commission of Zhejiang Province [2020KY558]

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Pyoderma gangrenosum (PG) is a rare autoinflammatory skin disorder with challenging treatment. We reported a patient with coexisting PG, plaque psoriasis, and palmoplantar pustulosis (PPP) who recovered after treatment with adalimumab.
Pyoderma gangrenosum (PG) is a rare autoinflammatory skin disorder, which is characterised by rapidly developing and tender cutaneous ulcers. The treatment of PG is challenging. Palmoplantar pustulosis (PPP) is also an autoinflammatory dermatosis with sterile pustules on the palms and/or the soles. We demonstrated a 68-year-old patient with coexisting autoinflammatory diseases including PG, 1-year history of plaque psoriasis and PPP, recovered after treatment with adalimumab. We also reviewed published reports of PG-associated autoinflammatory syndromes with adalimumab.

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