期刊
FOOD SCIENCE AND HUMAN WELLNESS
卷 11, 期 5, 页码 1373-1383出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.fshw.2022.04.037
关键词
Hydrogel; Carboxymethyl konjac glucomannan; Gelatin; Tannic acid; Biodegradation; Sustained release
资金
- National Natural Science Foundation of China [31772045]
- program on Fujian Agriculture and Forestry University of doctoral students going abroad [324-112110089]
- scientific research foundation graduate school of Fujian Agriculture and Forestry University [324-1122yb064]
This study reports a composite hydrogel composed of multiple biocompatible materials, which exhibits good biodegradability and pH sensitivity. The incorporation of functional nano-hydroxyapatite improves the physico-chemical properties of the hydrogel. The study demonstrates that the hydrogel has enhanced drug release, biocompatibility, and encapsulation properties.
Development of functional bioinspired hydrogels that have good releases control character is necessary for the application of these materials in biomedical engineering. Herein, we report a composite hydrogel prepared from several biocompatible carboxymethyl konjac glucomannan (CKGM)/gelatin (G)/tannic acid (TA) functional nano-hydroxyapatite (TA@n-HA), which has good biodegradability and pH sensitivity. The mechanism of interaction between hydrogels was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, Scanning electron microscopy and Thermogravimetric analysis. The physico-chemical properties of CKGM/G hydrogels have been significantly improved through the incorporation of TA@n-HA within the matrix. Studies in the sustained release of epigallocatechin gallate (EGCG) demonstrated that the TA@n-HA/CKGM/G hydrogels exhibit not only better pH sensitive properties, but also enhanced biocompatibility and encapsulation in comparison to the matrix devoid of TA@n-HA. Consequently, TA@n-HA/CKGM/G hydrogels using EGCG as a drug release model show the potential for drug delivery. (c) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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