期刊
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
卷 27, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0960-1317/27/1/015008
关键词
micromixing; high-viscosity fluid; acoustofluidics; polyethylene glycol (PEG)
类别
资金
- National Institutes of Health [R01 GM112048, R33 EB019785]
- National Science Foundation [CBET-1438126, IDBR-1455658]
- Center for Nanoscale Science, a National Science Foundation (NSF) Materials Research Science and Engineering Center [DMR-1420620]
- Turkey's Ministry of National Education
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1455658] Funding Source: National Science Foundation
We present an acoustofluidic micromixer which can perform rapid and homogeneous mixing of highly viscous fluids in the presence of an acoustic field. In this device, two high-viscosity polyethylene glycol (PEG) solutions were co-injected into a three-inlet PDMS microchannel with the center inlet containing a constant stream of nitrogen flow which forms bubbles in the device. When these bubbles were excited by an acoustic field generated via a piezoelectric transducer, the two solutions mixed homogenously due to the combination of acoustic streaming, droplet ejection, and bubble eruption effects. The mixing efficiency of this acoustofluidic device was evaluated using PEG-700 solutions which are similar to 106 times more viscous than deionized (DI) water. Our results indicate homogenous mixing of the PEG-700 solutions with a similar to 0.93 mixing index. The acoustofluidic micromixer is compact, inexpensive, easy to operate, and has the capacity to mix highly viscous fluids within 50 ms.
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