4.6 Review

The Role of Neutrophils in Pregnancy, Term and Preterm Labour

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Obstetrics & Gynecology

Intra-amniotic infection and sterile intra-amniotic inflammation are associated with elevated concentrations of cervical fluid interleukin-6 in women with spontaneous preterm labor with intact membranes

Jaroslav Stranik et al.

Summary: This study aimed to determine the concentration of IL-6 in cervical fluid in women with PTL. Results showed that women with intra-amniotic infection and sterile intra-amniotic inflammation had higher concentrations of IL-6 in cervical fluid compared to those without intra-amniotic inflammation, indicating an association between intra-amniotic inflammation and elevated IL-6 levels in cervical fluid.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

Review Biochemistry & Molecular Biology

Roles of neutrophil granule proteins in orchestrating inflammation and immunity

Amira Othman et al.

Summary: Neutrophil granulocytes play a crucial role in host defense and inflammation, with granule proteins having diverse functions beyond just antimicrobial activity. Understanding the roles of granule proteins in regulating inflammatory responses is important for minimizing tissue damage and restoring homeostasis. Targeting granule proteins and signaling pathways could hold therapeutic potential for various diseases.

FEBS JOURNAL (2022)

Article Multidisciplinary Sciences

Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response

Denise Chan et al.

Summary: This study provides mechanistic insight into the role of vaginal microbiota and immunological factors in spontaneous preterm birth (sPTB). The findings suggest that the complement system, in conjunction with specific vaginal microbial and associated immunological changes, contributes to the development of sPTB.

NATURE COMMUNICATIONS (2022)

Article Cell Biology

Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation

Marcelo Farias-Jofre et al.

Summary: During pregnancy, the immune responses of circulating monocytes and neutrophils to endotoxin, a Gram-negative bacterial product, are altered.

INFLAMMATION RESEARCH (2022)

Article Microbiology

Neutrophils Dominate the Cervical Immune Cell Population in Pregnancy and Their Transcriptome Correlates With the Microbial Vaginal Environment

Amirah Mohd Zaki et al.

Summary: This study investigated the immune cell populations at the cervicovaginal interface in early to mid-pregnancy and their association with the cervicovaginal microbiota. The findings suggest that neutrophils are the dominant immune cell type in the cervix during pregnancy and their transcriptome may be modified in response to the microbial environment. These results establish the rationale for further research on the associations between the innate immune response, cervical shortening, and spontaneous preterm birth.

FRONTIERS IN MICROBIOLOGY (2022)

Meeting Abstract Obstetrics & Gynecology

Category - High Risk Pregnancy

[Anonymous]

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022)

Article Biochemistry & Molecular Biology

Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term

Violetta Florova et al.

Summary: The study revealed that specific soluble immune mediators, especially CXCL10, were negatively correlated with typical members of CST IV of the vaginal microbiome. Sneathia sanguinegens showed stronger negative associations with various immune mediators, including CXCL10 and CCL26, in women who ultimately underwent PTB compared to term deliveries, providing insights into vaginal host immune-microbiome interactions in different pregnancy outcomes.

CYTOKINE (2021)

Review Cell Biology

The Association of Inflammatory Biomarker of Neutrophil-to-Lymphocyte Ratio with Spontaneous Preterm Delivery: A Systematic Review and Meta-analysis

Sina Vakili et al.

Summary: The meta-analysis found that NLR levels are higher in patients with preterm delivery. NLR could be a useful biomarker for predicting preterm delivery, but further prospective case-control studies are needed to strengthen the evidence.

MEDIATORS OF INFLAMMATION (2021)

Article Multidisciplinary Sciences

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor

Nanase Takahashi et al.

Summary: The study revealed that the production of PGE(2) in fetal-membrane is influenced by COXs, cPGES, and SLCO2A1, which play roles in the accumulation of PGE(2) in amniotic fluid.

PLOS ONE (2021)

Review Biochemistry & Molecular Biology

The reproductive tract microbiota in pregnancy

Karen Grewal et al.

Summary: The microbiota in the reproductive tract plays a crucial role in maintaining normal pregnancy and influencing reproductive outcomes, with their role in immune modulation still being uncovered. This review discusses the composition of vaginal microbial communities and their association with reproductive outcomes, as well as strategies for manipulating microbiota composition to improve reproductive outcomes. Future developments in this field and the need for mechanistic studies to explore the functional significance of reproductive tract microbial communities are also highlighted.

BIOSCIENCE REPORTS (2021)

Review Immunology

Neutrophils in pregnancy: New insights into innate and adaptive immune regulation

Serena Bert et al.

Summary: The immunology of pregnancy focuses on how the mother tolerates the semi-allogeneic fetus, involving a balance of immune cells between pro-inflammatory functions and immunosuppressive activity depending on gestation time. Neutrophils at the maternal-fetal interface play a role in pregnancy, but their functions and interactions with T cells remain largely unknown.

IMMUNOLOGY (2021)

Article Immunology

RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection

Nardhy Gomez-Lopez et al.

Summary: The study found significant transcriptomic differences between amniotic fluid neutrophils and monocytes/macrophages in women with intra-amniotic infection, suggesting distinct roles for these cells. Transcriptome of fetal and maternal immune cells in the amniotic fluid varies, and immune cells from preterm deliveries exhibit enhanced transcriptional activity compared to those from term deliveries.

JOURNAL OF INNATE IMMUNITY (2021)

Review Immunology

Neutrophil chemoattractant receptors in health and disease: double-edged swords

Mieke Metzemaekers et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth

Natasha L. Hezelgrave et al.

SCIENTIFIC REPORTS (2020)

Review Immunology

The pregnancy microbiome and preterm birth

Erna Bayar et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

Article Obstetrics & Gynecology

Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study

N. Tabatabaei et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2019)

Article Multidisciplinary Sciences

Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery

Michal A. Elovitz et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

The vaginal microbiome and preterm birth

Jennifer M. Fettweis et al.

NATURE MEDICINE (2019)

Review Physiology

THE NEUTROPHIL'S ROLE DURING HEALTH AND DISEASE

Pei Xiong Liew et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Obstetrics & Gynecology

The rote of complement in preterm birth and prematurity

Norma Galindo-Sevilla et al.

JOURNAL OF PERINATAL MEDICINE (2019)

Article Immunology

The immunophenotype of amniotic fluid leukocytes in normal and complicated pregnancies

Nardhy Gomez-Lopez et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2018)

Review Immunology

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

Giang T. Nguyen et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Article Obstetrics & Gynecology

Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?

Nardhy Gomez-Lopez et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2017)

Article Immunology

Amniotic fluid neutrophils can phagocytize bacteria: A mechanism for microbial killing in the amniotic cavity

Nardhy Gomez-Lopez et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2017)

Article Immunology

An immune clock of human pregnancy

Nima Aghaeepour et al.

SCIENCE IMMUNOLOGY (2017)

Review Immunology

The unique immunological and microbial aspects of pregnancy

Gil Mor et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Immunology

Cervical leukocytes and spontaneous preterm birth

Patricia J. Hunter et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2016)

Article Cell Biology

Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage

Lindsay M. Kindinger et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Developmental Biology

Sterile inflammation and pregnancy complications: a review

Mathieu Nadeau-Vallee et al.

REPRODUCTION (2016)

Review Obstetrics & Gynecology

Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

Chong Jai Kim et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

Article Immunology

Phagocytic index of neutrophil granulocytes and monocytes in healthy and preeclamptic pregnancy

Rudolf Lampe et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

Article Immunology

Blood SC5b-9 complement levels increase at parturition during term and preterm labor

Enrique Segura-Cervantes et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Temporal and spatial variation of the human microbiota during pregnancy

Daniel B. DiGiulio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Physiology

Human cervicovaginal fluid biomarkers to predict term and preterm labor

Yujing J. Heng et al.

FRONTIERS IN PHYSIOLOGY (2015)

Article Multidisciplinary Sciences

Cervical Microbiota in Women with Preterm Prelabor Rupture of Membranes

Marian Kacerovsky et al.

PLOS ONE (2015)

Review Immunology

Understanding the Complexity of the Immune System during Pregnancy

Karen Racicot et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2014)

Article Immunology

Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses

Natascha Koestlin et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Characterization of Neutrophil Subsets in Healthy Human Pregnancies

Aloysius Ssemaganda et al.

PLOS ONE (2014)

Article Obstetrics & Gynecology

Altered CD16 expression on vaginal neutrophils from women with vaginitis

Joziani Beghini et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2013)

Article Immunology

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Krisztina Futosi et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2013)

Review Immunology

Damage-Associated Molecular Patterns Control Neutrophil Recruitment

Keir Pittman et al.

JOURNAL OF INNATE IMMUNITY (2013)

Review Immunology

Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Immunology

Identification of Immune Cells by Flow Cytometry in Vaginal Lavages from Women with Vulvovaginitis and Normal Microflora

Paulo Cesar Giraldo et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2012)

Article Reproductive Biology

Complement C5a Regulates Prolabor Mediators in Human Placenta

Martha Lappas et al.

BIOLOGY OF REPRODUCTION (2012)

Review Hematology

Physiological Changes in Hematological Parameters During Pregnancy

Surabhi Chandra et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2012)

Review Cell Biology

The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour

Lynne Sykes et al.

MEDIATORS OF INFLAMMATION (2012)

Article Multidisciplinary Sciences

A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in Pregnancy

Kjersti Aagaard et al.

PLOS ONE (2012)

Article Pediatrics

Intrauterine infection and preterm labor

Varkha Agrawal et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2012)

Editorial Material Hematology

Immature granulocytes in pregnancy: A story of Virchow, anxious fathers, and expectant mothers

Michael H. A. Roehrl et al.

AMERICAN JOURNAL OF HEMATOLOGY (2011)

Review Cell Biology

Endocrine immune interactions in human parturition

E. Golightly et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

Article Rheumatology

IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy

Waldiceu A. Verri et al.

ANNALS OF THE RHEUMATIC DISEASES (2010)

Article Obstetrics & Gynecology

Diagnosis and Management of Clinical Chorioamnionitis

Alan T. N. Tita et al.

CLINICS IN PERINATOLOGY (2010)

Article Biochemistry & Molecular Biology

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Thomas B. Clarke et al.

NATURE MEDICINE (2010)

Article Nutrition & Dietetics

Immunology of pregnancy

Catherine A. Thornton

PROCEEDINGS OF THE NUTRITION SOCIETY (2010)

Review Rheumatology

Neutrophil function in inflammation and inflammatory diseases

Helen L. Wright et al.

RHEUMATOLOGY (2010)

Review Immunology

Sterile inflammation: sensing and reacting to damage

Grace Y. Chen et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Obstetrics & Gynecology

Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix

Shrikant Bollopragada et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2009)

Article Immunology

TLR9 Activation Coupled to IL-10 Deficiency Induces Adverse Pregnancy Outcomes

Jessica E. Thaxton et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Obstetrics & Gynecology

Evidence for complement activation in the amniotic fluid of women with spontaneous preterm labor and intra-amniotic infection

Eleazar Soto et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2009)

Article Developmental Biology

Leukocytes are primed in peripheral blood for activation during term and preterm labour

M. Yuan et al.

MOLECULAR HUMAN REPRODUCTION (2009)

Article Multidisciplinary Sciences

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Shankar S. Iyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Obstetrics & Gynecology

Inflammation and Pregnancy

John R. Challis et al.

REPRODUCTIVE SCIENCES (2009)

Review Obstetrics & Gynecology

Biochemical and endocrinological preparation for parturition

Vasso Trzidou

BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY (2007)

Article Obstetrics & Gynecology

Cervical function and prematurity

Jane E. Norman

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2007)

Article Biochemistry & Molecular Biology

Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils

Mireille St-Onge et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

Article Immunology

Cervical leukocyte sub-populations in idiopathic preterm labour

M. K. Whitworth et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2007)

Article Immunology

Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy

Pascale Kropf et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Review Obstetrics & Gynecology

Dynamics of cervical remodeling during pregnancy and parturition: Mechanisms and current concepts

R. Ann Word et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2007)

Article Obstetrics & Gynecology

Leukocyte density and proinflammatory mediator expression in regional human fetal membranes and decidua before and during labor at term

I Osman et al.

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2006)

Article Obstetrics & Gynecology

Evaluation of amniotic fluid cytokines in preterm labor and intact membranes

R Figueroa et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2005)

Article Immunology

Macrophages and not granulocytes are involved in cervical ripening

Y Sakamoto et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2005)

Article Obstetrics & Gynecology

Immunoglobulin levels and phagocytes in the cervical mucus plug at term of pregnancy

M Hein et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2005)

Article Obstetrics & Gynecology

Normal labor: Mechanism and duration

JB Liao et al.

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (2005)

Article Multidisciplinary Sciences

Neutrophil extracellular traps kill bacteria

V Brinkmann et al.

SCIENCE (2004)

Article Immunology

Interleukin-8 is involved in cervical dilatation but not in prelabour cervical ripening

Y Sakamoto et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2004)

Review Immunology

Neutrophil granules and secretory vesicles in inflammation

M Faurschou et al.

MICROBES AND INFECTION (2003)

Article Obstetrics & Gynecology

Elevated vaginal pH and neutrophils are associated strongly with early spontaneous preterm birth

HN Simhan et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2003)

Review Hematology

Surface antigen changes during normal neutrophilic development: A critical review

MT Elghetany

BLOOD CELLS MOLECULES AND DISEASES (2002)

Article Obstetrics & Gynecology

Phenotypic and metabolic characteristics of monocytes and granulocytes in normal pregnancy and maternal infection

N Naccasha et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2001)

Article Obstetrics & Gynecology

Phenotypic and metabolic characteristics of maternal monocytes and granulocytes in preterm labor with intact membranes

MT Gervasi et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2001)

Article Obstetrics & Gynecology

Umbilical arteritis and phlebitis mark different stages of the fetal inflammatory response

CJ Kim et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2001)

Article Developmental Biology

Human cervical ripening, an inflammatory process mediated by cytokines

MB Sennström et al.

MOLECULAR HUMAN REPRODUCTION (2000)

Article Immunology

Interleukin-8 levels and granulocyte counts in cervical mucus during pregnancy

LH Luo et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2000)