期刊
LIFE-BASEL
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/life12101512
关键词
neutrophils; pregnancy; term labour; premature labour; vaginal microbiota; inflammation
资金
- March of Dimes [WSCRP76171]
- Parasol Foundation [DRP2122_05]
- National Institute for Health Research Comprehensive Biomedical Research Centre at Imperial College Healthcare NHS Trust
- Imperial College London
Neutrophils are surveillance cells that play a key role in both sterile inflammation and infection. They are important in both term and preterm deliveries and contribute to tissue remodelling.
Neutrophils are surveillance cells, and the first to react and migrate to sites of inflammation and infection following a chemotactic gradient. Neutrophils play a key role in both sterile inflammation and infection, performing a wide variety of effector functions such as degranulation, phagocytosis, ROS production and release of neutrophil extracellular traps (NETs). Healthy term labour requires a sterile pro-inflammatory process, whereas one of the most common causes of spontaneous preterm birth is microbial driven. Peripheral neutrophilia has long been described during pregnancy, and evidence exists demonstrating neutrophils infiltrating the cervix, uterus and foetal membranes during both term and preterm deliveries. Their presence supports a role in tissue remodelling via their effector functions. In this review, we describe the effector functions of neutrophils. We summarise the evidence to support their role in healthy pregnancy and labour and describe their potential contribution to microbial driven preterm birth.
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