期刊
LIFE-BASEL
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/life12091365
关键词
lung cancer; squamous cell lung carcinoma; sputum microbiome; taxonomic composition; Streptococcus
资金
- Russian Science Foundation [18-14-00022p]
This study compared the taxonomic composition of the sputum microbiome between untreated LUSC patients and healthy controls. The results showed significant differences in the structure of bacterial communities between the two groups. Certain genera were found to be enriched in LUSC patients, while others were significantly reduced, indicating a decrease in beta diversity in the microbiome of LUSC patients.
Background: Recent findings indicate that the host microbiome can have a significant impact on the development of lung cancer by inducing an inflammatory response, causing dysbiosis, and generating genome damage. The aim of this study was to search for bacterial communities specifically associated with squamous cell carcinoma (LUSC). Methods: In this study, the taxonomic composition of the sputum microbiome of 40 men with untreated LUSC was compared with that of 40 healthy controls. Next-Generation sequencing of bacterial 16S rRNA genes was used to determine the taxonomic composition of the respiratory microbiome. Results: There were no differences in alpha diversity between the LUSC and control groups. Meanwhile, differences in the structure of bacterial communities (beta diversity) among patients and controls differed significantly in sputum samples (pseudo-F = 1.53; p = 0.005). Genera of Streptococcus, Bacillus, Gemella, and Haemophilus were found to be significantly enriched in patients with LUSC compared to the control subjects, while 19 bacterial genera were significantly reduced, indicating a decrease in beta diversity in the microbiome of patients with LUSC. Conclusions: Among other candidates, Streptococcus (Streptococcus agalactiae) emerges as the most likely LUSC biomarker, but more research is needed to confirm this assumption.
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