☆ 4.7 Review

Advances in Biosensing Technologies for Diagnosis of COVID-19

BIOSENSORS-BASEL (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biophysics

Rapid, multiplexed, and nucleic acid amplification-free detection of SARS-CoV-2 RNA using an electrochemical biosensor

Leila Kashefi-Kheyrabadi et al.

Summary: The study introduces a novel nucleic acid amplification-free electrochemical biosensor for rapid and simultaneous detection of different genes of SARS-CoV-2, showing promising performance in clinical samples and potential for on-site, real-time diagnostic testing for COVID-19.

BIOSENSORS & BIOELECTRONICS (2022)

添加到收藏夹

Article Biophysics

SPEEDS: A portable serological testing platform for rapid electrochemical detection of SARS-CoV-2 antibodies

Ran Peng et al.

Summary: The study developed a portable and low-cost electrochemical immunosensor for rapid and accurate quantification of SARS-CoV-2 antibodies, specifically IgG and IgM. It can provide quantitative measurements in a short assay time, making it suitable for rapid COVID-19 serological testing for both point-of-care diagnosis and population immunity screening.

BIOSENSORS & BIOELECTRONICS (2022)

添加到收藏夹

Review Biochemical Research Methods

The screening value of RT-LAMP and RT-PCR in the diagnosis of COVID-19: systematic review and meta-analysis

Ruiyang Pu et al.

Summary: This systematic review evaluates the test accuracy of RT-LAMP and RT-PCR for diagnosing COVID-19. The overall sensitivity of RT-PCR and RT-LAMP was found to be 0.96 and 0.92, respectively, with false-negative rates of 0.06 and 0.12. Subgroup analysis suggests that mixed sampling and multiple target gene diagnosis methods have better diagnostic value. The study shows that RT-PCR and RT-LAMP have high value in diagnosing COVID-19, but there is still a false-negative rate of about 6%-12%.

JOURNAL OF VIROLOGICAL METHODS (2022)

添加到收藏夹

Review Chemistry, Analytical

A review on corona virus disease 2019 (COVID-19): current progress, clinical features and bioanalytical diagnostic methods

Fariba Mollarasouli et al.

Summary: This paper summarizes the COVID-19 pandemic, clinical features, epidemiology, and pathogenesis. It also focuses on recent advances in bioanalytical diagnostic methods for SARS-CoV-2 sensing. Additionally, it presents the mechanisms, advantages, and disadvantages of the most common biosensors for COVID-19 detection.

MICROCHIMICA ACTA (2022)

添加到收藏夹

Review Chemistry, Physical

Nanotechnology: A Potential Weapon to Fight against COVID-19

Atul K. Tiwari et al.

Summary: The urgency of exploring nanomaterials as effective and safe approaches for treating COVID-19 infections is becoming increasingly prominent. Nanomaterials have potential applications in detecting viral antigens and host antibodies, suppressing cytokine storms, and delivering antiviral drugs efficiently.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2022)

添加到收藏夹

Article Chemistry, Analytical

Silver nanotriangle array based LSPR sensor for rapid coronavirus detection

Yanjun Yang et al.

Summary: The researchers developed a rapid coronavirus detection method using a functionalized silver nanotriangle array localized surface plasmon resonance sensor. The sensor shows high sensitivity and specificity in detecting SARS-CoV-2 infection, and the detection time is less than 20 minutes.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Determination of human COVID-19 total antibodies in serum using a time-resolved fluorescence immunoassay

Yunjian Xu et al.

Summary: Here, we established a new time-resolved fluorescence immunoassay (TRFIA) for the detection of total antibodies in COVID-19 patients. This method showed high sensitivity and accuracy, providing a new option for high-throughput routine diagnosis.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

添加到收藏夹

Article Biophysics

Rapid biosensing SARS-CoV-2 antibodies in vaccinated healthy donors

Sumin Bian et al.

Summary: This study reports the development of two fiber optic-biolayer interferometry (FO-BLI)-based biosensors for rapid detection of SARS-CoV-2 neutralizing antibodies (NAbs) and binding antibodies (BAbs) in human serum. The biosensors demonstrated high sensitivity and speed in detecting antibodies, and the results correlated well with a commercial assay kit. The clinical utility of the biosensors was further validated using a small cohort of vaccinated individuals. The findings have important implications for COVID-19 vaccine trials, immune response dynamics research, and epidemiology studies.

BIOSENSORS & BIOELECTRONICS (2022)

添加到收藏夹

Article Biophysics

Versatile role of ACE2-based biosensors for detection of SARS-CoV-2 variants and neutralizing antibodies

Jong-Hwan Lee et al.

Summary: The study developed an ACE2-based biosensor that can detect S1 mutations and neutralizing antibodies of SARS-CoV-2. The biosensor can detect various variants and the wild-type SARS-CoV-2, distinguishing them based on color differences. This approach will facilitate the development of various biosensors against SARS-CoV-2.

BIOSENSORS & BIOELECTRONICS (2022)

添加到收藏夹

Article Biophysics

Electrochemical biosensor for nucleic acid amplification-free and sensitive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA via CRISPR/Cas13a trans-cleavage reaction

Woong Heo et al.

Summary: A electrochemical biosensor based on CRISPR/Cas13a was developed for the rapid and sensitive detection of SARS-CoV-2 without the need for nucleic acid amplification. The biosensor showed high sensitivity and a wide detection range, making it suitable for on-site rapid diagnostic testing.

BIOSENSORS & BIOELECTRONICS (2022)

添加到收藏夹

Review Virology

Biomarker based biosensors: An opportunity for diagnosis of COVID-19

Reza Khaksarinejad et al.

Summary: Early diagnosis and treatment are crucial for human health. Detection of biomarkers is an efficient method for early diagnosis. Most biomarker detection currently takes place in dedicated laboratories, which is time-consuming and costly. Smaller and cheaper devices could replace traditional laboratory analyses for real-time point-of-care diagnostics. Early diagnosis of COVID-19 patients is essential for timely quarantine and treatment strategies.

REVIEWS IN MEDICAL VIROLOGY (2022)

添加到收藏夹

Review Nanoscience & Nanotechnology

Aptamers as promising nanotheranostic tools in the COVID-19 pandemic era

Christian K. O. Dzuvor et al.

Summary: The rapid detection and treatment of SARS-COV-2 are crucial for controlling the pandemic. Aptamers provide a potential alternative for detecting the virus and treating COVID-19, with high affinity and multifunctionality.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Review Immunology

Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19

Denise Battaglini et al.

Summary: This article summarizes the commonly used biomarkers in COVID-19, which play important roles in predicting disease severity, hospitalization, ICU admission, and mortality. It also discusses how novel analytical strategies can be applied in clinical practice, emphasizing the need for future research to focus on identifying a limited but essential number of laboratory biomarkers for predicting prognosis and outcomes in severe COVID-19.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Nanomaterials-based sensors for the detection of COVID-19: A review

Gowhar A. Naikoo et al.

Summary: With the lack of an effective and safest vaccine to combat COVID-19 and its variants, there is an urgent need for the development of rapid and selective diagnostic devices. Nanomaterial-based biosensors show immense potential in detecting the virus in real-time with noninvasive and cost-effective properties. This review provides an overview of existing and potential nanomaterial-based biosensors, as well as the practical tools and techniques required for their development.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Chemistry, Analytical

Microfluidics-Based Biosensing Platforms: Emerging Frontiers in Point-of-Care Testing SARS-CoV-2 and Seroprevalence

Elda A. Flores-Contreras et al.

Summary: This article discusses the application of microfluidic technology in the detection of SARS-CoV-2 and seroprevalence, and describes commercially available alternatives based on microfluidic platforms. Timely and accurate results are crucial for healthcare professionals to provide efficient treatments and make appropriate decisions.

BIOSENSORS-BASEL (2022)

添加到收藏夹

Review Chemistry, Analytical

Review of COVID-19 testing and diagnostic methods

Olena Filchakova et al.

Summary: More than six billion tests for COVID-19 have been conducted worldwide. This article emphasizes the importance of testing for the SARS-CoV-2 virus and corresponding human antibodies, not only for medical diagnosis and treatment, but also for economic and social activities. The review discusses the parameters of these tests and compares different detection methods. While RT-PCR remains the gold standard, there is a need for alternative methods that are less expensive and more accessible.

TALANTA (2022)

添加到收藏夹

Article Engineering, Biomedical

A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma

Devora Najjar et al.

Summary: A 3D-printed lab-on-a-chip has been developed for rapid and accurate detection of SARS-CoV-2 RNA and antibodies, providing a convenient method for determining immune status in individuals.

NATURE BIOMEDICAL ENGINEERING (2022)

添加到收藏夹

Article Chemistry, Analytical

Rapid Quantification of SARS-Cov-2 Spike Protein Enhanced with a Machine Learning Technique Integrated in a Smart and Portable Immunosensor

Simone Fortunati et al.

Summary: A smart and portable electrochemical immunosensor with IoT-WiFi capability was developed for quantifying the SARS-CoV-2 spike protein, and machine learning features were integrated. The immunoenzymatic sensor utilizes monoclonal antibodies that are immobilized on gold nanoparticles functionalized screen-printed electrodes. The sensor exhibited remarkable specificity and was validated using a viral transfer medium commonly used for nasopharyngeal swab desorption. Machine learning algorithms were employed for data processing and analysis, with different support vector machine classifiers evaluated for their accuracy. The best classification model achieved a test accuracy of 97.3% for true positive/true negative sample classifications. Furthermore, the ML algorithm can be easily integrated into cloud-based portable WiFi devices. The immunosensor was successfully tested for whole virus detection using a replicating incompetent lentiviral vector pseudotyped with SARS-CoV-2 spike glycoprotein.

BIOSENSORS-BASEL (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Recent advances in point of care testing for COVID-19 detection

Renata Salgado Fernandes et al.

Summary: The COVID-19 pandemic has fueled relentless exploration in diagnostic tests, treatments, and vaccines. RT-PCR remains the gold standard for diagnosis, but other molecular techniques and immunoassays have emerged. The development of rapid, accessible tests has led to the rise of point of care tests (POCT) that reduce pressure on screening and detection.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Article Biophysics

COVID-19 diagnosis - A review of current methods

Meral Yuce et al.

Summary: A fast and accurate self-testing tool for COVID-19 diagnosis is crucial for understanding the global situation and taking appropriate actions. The diagnosis tools available mainly rely on viral gene detection, human antibody detection, and viral antigen detection, with RT-PCR being the most reliable technique.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Review Cell Biology

Antibody detection assays for COVID-19 diagnosis: an early overview

Sarfaraz Ahmad Ejazi et al.

Summary: Researchers worldwide are intensifying efforts to control the spread of COVID-19, with a focus on finding alternative testing methods. The rapid development of immunological tests is proving to be effective in diagnosing viral infections, offering a potential solution to the challenges posed by high prices and lengthy procedures of current molecular tests.

IMMUNOLOGY AND CELL BIOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Simultaneous Dual-Gene Diagnosis of SARS-CoV-2 Based on CRISPR/Cas9-Mediated Lateral Flow Assay

Erhu Xiong et al.

Summary: The newly developed method can simultaneously detect two SARS-CoV-2 genes in a single test, showing high sensitivity and accuracy, providing a more accurate and convenient pathway for COVID-19 diagnosis in low-resource regions.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Biophysics

Magnetic beads combined with carbon black -based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva

Laura Fabiani et al.

Summary: The study developed an electrochemical immunoassay for rapid and smart detection of SARS-CoV-2 coronavirus in saliva, with high sensitivity, rapid analysis (30 min), miniaturization, portability, and ease of use.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Article Biophysics

A novel rapid detection for SARS-CoV-2 spike 1 antigens using human angiotensin converting enzyme 2 (ACE2)

Jong-Hwan Lee et al.

Summary: This study presents a novel rapid detection method for the SARS-CoV-2 S1 antigen using a matched pair of ACE2 and antibody. The detection method showed high specificity and sensitivity without cross-reactivity, making it a valuable tool in detecting the S1 antigen from COVID-19 patients.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Article Biophysics

Development of a portable MIP-based electrochemical sensor for detection of SARS-CoV-2 antigen

Abdul Raziq et al.

Summary: The newly developed MIP-based electrochemical sensor for detecting SARS-CoV-2 nucleoprotein shows a linear response up to 111 fM, with detection and quantification limits of 15 fM and 50 fM. This sensor has the capability to detect ncovNP in nasopharyngeal swab samples of COVID-19 positive patients, providing a new route for rapid COVID-19 diagnostic tools.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing

Hanie Yousefi et al.

Summary: The development of new methods for direct viral detection is crucial in combating the COVID-19 pandemic. This reagent-free viral sensing approach can detect the presence of viral particles and proteins within 5 minutes, providing a rapid and effective solution for identifying viruses like SARS-CoV-2.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Review Immunology

Coronavirus disease 2019 (COVID-19): An overview of the immunopathology, serological diagnosis and management

Abubakar Umar Anka et al.

Summary: SARS-CoV-2 infection results in COVID-19, characterized by pneumonia and acute respiratory distress syndrome. The disease triggers inflammatory responses that can cause tissue damage, along with reduced immune cells and cytokine storm in severe cases. Treatment involves antiviral agents and immunomodulators, with varied efficacy, while potential options continue to be explored for combating COVID-19 severity and transmission.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Article Chemistry, Analytical

Ultrasensitive supersandwich-type electrochemical sensor for SARS-CoV-2 from the infected COVID-19 patients using a smartphone

Hui Zhao et al.

Summary: The study developed an ultrasensitive electrochemical detection technology using calixarene functionalized graphene oxide for targeting SARS-CoV-2 RNA without the need for nucleic acid amplification and reverse transcription. The biosensor demonstrated high specificity and selectivity, offering a rapid and convenient method for SARS-CoV-2 detection at the point of care.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Rapid Detection of SARS-CoV-2 Antigens Using High-Purity Semiconducting Single-Walled Carbon Nanotube-Based Field-Effect Transistors

Wenting Shao et al.

Summary: This study demonstrates the use of a high-purity semiconducting single-walled carbon nanotube field-effect transistor for rapid detection of SARS-CoV-2 antigens, displaying high sensitivity and specificity.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Biophysics

Paper-based electrochemical biosensor for diagnosing COVID-19: Detection of SARS-CoV-2 antibodies and antigen

Abdulhadee Yakoh et al.

Summary: A specific and sensitive immunosensor has been developed for the detection of immunoglobulins produced against SARS-CoV-2, targeting SARS-CoV-2 antibodies without the need for specific antibodies. This sensor has shown effective results in real clinical sera and has the potential for expanded use in antigen detection, presenting new possibilities for diagnosing COVID-19.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Article Chemistry, Analytical

An electrochemical immunosensor using SARS-CoV-2 spike protein-nickel hydroxide nanoparticles bio-conjugate modified SPCE for ultrasensitive detection of SARS-CoV-2 antibodies

Zeinab Rahmati et al.

Summary: This study designed a robust electrochemical biosensor for selective and quantitative analysis of SARS-CoV-2-specific viral antibodies, demonstrating high sensitivity and specificity in experiments without the need for labeling, making it a sensitive immunological diagnostic method for SARS-CoV-2 antibodies.

MICROCHEMICAL JOURNAL (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultrasensitive Detection of SARS-CoV-2 Antibody by Graphene Field-Effect Transistors

Hua Kang et al.

Summary: The development of a graphene field-effect transistor (g-FET) biosensor has enabled ultrasensitive detection of SARS-CoV-2 antibodies with rapid and precise diagnosis capabilities. This technology holds great promise in future prevention and control of other epidemic outbreaks.

NANO LETTERS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry

Julian Valero et al.

Summary: A special RNA aptamer with high affinity to the receptor binding domain of SARS-CoV-2 spike protein has been discovered, preventing its interaction with the host receptor and efficiently blocking viral infection. Trimerized version of the aptamer enhances binding affinity, showing potential for widespread use in detecting and treating SARS-CoV-2 and emerging variants.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Chemistry, Analytical

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Anchal Pradhan et al.

Summary: Recent advances in biosensor technology have provided selective, sensitive, and affordable techniques for disease detection, with nanobiosensors playing a crucial role. Nanotechnology has significantly enhanced disease and pandemic management, reflecting the potential of biosensors in rapid COVID-19 identification. This report highlights the state-of-the-art virus detection methods and challenges, including newly emerging technologies such as optically enhanced and wearable nanobiosensors.

SENSORS (2021)

添加到收藏夹

Article Chemistry, Analytical

Development of a SERS-based lateral flow immunoassay for rapid and ultra-sensitive detection of anti-SARS-CoV-2 IgM/IgG in clinical samples

Haifeng Liu et al.

Summary: This study reported a surface-enhanced Raman scattering-based lateral flow immunoassay method for the high sensitivity simultaneous detection of anti-SARS-CoV-2 IgM/IgG. The method utilized custom SERS tags and dual layers of Raman dye, with signal intensities easily recorded by a portable Raman instrument for high sensitivity analysis. Validation on samples from COVID-19 patients and healthy individuals showed high accuracy and specificity.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Handheld Microfluidic Filtration Platform Enables Rapid, Low-Cost, and Robust Self-Testing of SARS-CoV-2 Virus

Jiang Xu et al.

Summary: The novel microfluidic test kit combines ultra-high throughput hydrodynamic filtration and sandwich immunoassay techniques for rapid separation and enrichment of antigens, demonstrating high detection sensitivity, low cost, and suitability for areas with inadequate medical infrastructure and limited laboratory resources.

SMALL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2

Marie-Ming Aynaud et al.

Summary: The study introduces a platform called C19-SPAR-Seq, which can analyze tens of thousands of patient samples for SARS-CoV-2 in a single run, with high specificity and sensitivity demonstrated through experimental trials in clinical diagnostics.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

Reverse Transcription Recombinase-Aided Amplification Assay With Lateral Flow Dipstick Assay for Rapid Detection of 2019 Novel Coronavirus

Yu-Zhong Zheng et al.

Summary: This study developed a rapid and specific Point of Care Test (POCT) for detecting SARS-CoV-2 outside of the laboratory setting. The assay showed 100% specificity and sensitivity in clinical sample detection, making it a convenient tool for screening and monitoring suspected cases of COVID-19 in endemic areas.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹

Article Chemistry, Analytical

Microfluidic Chip with Two-Stage Isothermal Amplification Method for Highly Sensitive Parallel Detection of SARS-CoV-2 and Measles Virus

Qin Huang et al.

Summary: A two-stage isothermal amplification method was developed for parallel and real-time detection of multiplex targets with high sensitivity and specificity. The microfluidic chip-based portable system can identify different nucleic acid samples simultaneously and in a timely manner at a low cost.

MICROMACHINES (2021)

添加到收藏夹

Article Biochemical Research Methods

Rapid detection of SARS-CoV-2 by pulse-controlled amplification (PCA)

Katrin Zwirglmaier et al.

Summary: In the current COVID-19 pandemic, a novel nucleic acid-based testing format called pulse controlled amplification was introduced, which is capable of detecting SARS-CoV-2 directly from multiple swab samples within 25 minutes without the need for RNA extraction, with a sensitivity of 100% for samples with high viral loads. This new approach may lead to rapid and sensitive point-of-care testing.

JOURNAL OF VIROLOGICAL METHODS (2021)

添加到收藏夹

Review Chemistry, Analytical

Biosensors promising bio-device for pandemic screening COVID-19

Ahmad Mobed et al.

Summary: The coronavirus pandemic has had a significant impact on both the medical and economic fields worldwide, highlighting the importance of early detection and accurate diagnosis. Routine methods for detecting coronaviruses have limitations such as false-positive/negative results, low sensitivity and specificity, and the need for advanced equipment, leading to the development of new technologies like biosensors to address these drawbacks and improve disease diagnosis.

MICROCHEMICAL JOURNAL (2021)

添加到收藏夹

Article Chemistry, Analytical

Peptide substrate screening for the diagnosis of SARS-CoV-2 using fluorescence resonance energy transfer (FRET) assay

Hani A. Alhadrami et al.

Summary: In this study, a specific, sensitive, quantitative, and fast detection method for SARS-CoV-2 using the FRET assay was developed, utilizing viral protease proteolytic activity as a biomarker. The method showed a high fluorescence signal with a low detection limit and specificity against MERS-CoV, indicating its potential application for diagnosing SARS-CoV-2 patients.

MICROCHIMICA ACTA (2021)

添加到收藏夹

Review Chemistry, Analytical

Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics

Linzhe Chen et al.

Summary: Diagnostic tools play significant roles in combating COVID-19, with emerging biosensing technologies offering rapid and highly sensitive tests, yet facing challenges in practical applications.

TALANTA (2021)

添加到收藏夹

Article Chemistry, Analytical

Anti-SARS-CoV-2 IgG and IgM detection with a GMR based LFIA system

Qiaoge Bayin et al.

Summary: The study introduces a novel lateral flow immunoassay method based on superparamagnetic nanoparticles and giant magnetoresistance sensing system for simultaneous quantitative detection of anti-SARS-CoV-2 immunoglobulin M and G. This method offers advantages in cost-effectiveness, time efficiency, and ease of operation.

TALANTA (2021)

添加到收藏夹

Review Chemistry, Analytical

Affinity Sensors for the Diagnosis of COVID-19

Maryia Drobysh et al.

Summary: The COVID-19 pandemic requires reducing the transmission rate, which can be achieved through the use of affinity sensors for diagnosis. Various methods such as nucleic acid hybridization, antigen-antibody interaction, and changes in reactive oxygen species (ROS) levels are used for generating analytical signals.

MICROMACHINES (2021)

添加到收藏夹

Article Chemistry, Analytical

Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors

Adrianna N. Masterson et al.

Summary: The diagnostic test presented is capable of accurately detecting multiple biomarkers of COVID-19 on a single platform, with high specificity, sensitivity, positive predictive value, and negative predictive value. It enables direct quantitative measurement of antibodies in plasma with high confidence and has potential applications beyond the current pandemic.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Biophysics

An electrochemical biosensor for sensitive analysis of the SARS-CoV-2 RNA

Ying Peng et al.

Summary: An electrochemical biosensor for sensitive monitoring of SARS-CoV-2 RNA has been proposed, with significantly amplified electrochemical signals and low detection limit, showing great prospects for clinical application in complex matrices and clinical patient samples.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Article Biophysics

Rapid and highly sensitive one-tube colorimetric RT-LAMP assay for visual detection of SARS-CoV-2 RNA

Yugan He et al.

Summary: The one-tube colorimetric RT-LAMP assay developed in this study integrates fast RNA extraction and rapid isothermal amplification in a single tube for the visual detection of SARS-CoV-2 RNA. The assay has a low limit of detection of 200 copies/mL and can be completed in less than 1 hour, showing 100% concordance with RT-qPCR and high specificity. This assay can be used as an alternative platform for rapid and sensitive diagnosis of COVID-19 in community clinics or township hospitals.

BIOSENSORS & BIOELECTRONICS (2021)

添加到收藏夹

Review Medicine, General & Internal

Prognostic value of neutrophil-to-lymphocyte ratio in COVID-19 patients: A systematic review and meta-analysis

Juan R. Ulloque-Badaracco et al.

Summary: Elevated NLR values are associated with increased severity and all-cause mortality in hospitalized COVID-19 patients, highlighting the importance of NLR in prognostic evaluation of COVID-19 patients.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

添加到收藏夹

Article Biochemical Research Methods

Digital PCR assay for the effective detection of COVID-19 patients with SARS-CoV-2 low viral load

Yong Sun et al.

Summary: Digital PCR (dPCR) is more sensitive than qPCR in detecting SARS-CoV-2, especially for samples with low viral load, while it has similar specificity to qPCR. It can effectively distinguish other human coronaviruses and influenza viruses, and is more sensitive than qPCR in detecting the virus in negative samples from recurrent COVID-19 patients.

JOURNAL OF VIROLOGICAL METHODS (2021)

添加到收藏夹

Article Chemistry, Analytical

Voltammetric-based immunosensor for the detection of SARS-CoV-2 nucleocapsid antigen

Shimaa Eissa et al.

Summary: A label-free square wave voltammetry-based biosensing platform for detecting SARS-CoV-2 in nasopharyngeal samples was developed with high sensitivity and selectivity. The biosensor demonstrated successful detection of the SARS-CoV-2 virus in clinical samples, showing a good correlation with RT-PCR cycle threshold values.

MICROCHIMICA ACTA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The early detection of immunoglobulins via optical-based lateral flow immunoassay platform in COVID-19 pandemic

Pang-Yen Chen et al.

Summary: A new optical platform is developed in this study for quantitative detection of antibodies in COVID-19 patients, showing significant advantages over other serum antibody reagents on the market. Early identification of elevated IgM levels in relation to COVID-19 infection is found, and the platform demonstrates sensitivity and accuracy in detecting RT-PCR negative patients.

PLOS ONE (2021)

添加到收藏夹

Article Virology

A Reverse Transcription Recombinase-Aided Amplification Method for Rapid and Point-of-Care Detection of SARS-CoV-2, including Variants

Fengyun Li et al.

Summary: The study proposes a rapid and on-site RT-RAA method for the detection of SARS-CoV-2, demonstrating high specificity and sensitivity for various strains, including current variants. This method can quickly detect lower virus copies at a constant temperature, with high agreement compared to RT-qPCR.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection

Masateru Taniguchi et al.

Summary: The study introduces a method for high sensitivity detection of novel coronaviruses using nanopores and artificial intelligence, eliminating the need for RNA extraction. It demonstrates that artificially intelligent nanopores can accurately identify four coronaviruses and detect SARS-CoV-2 in saliva specimens with high sensitivity.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Nutrition & Dietetics

Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis

Phil-Robin Tepasse et al.

Summary: This study found that in COVID-19 patients, plasma levels of vitamin A decrease during acute inflammation, and significantly reduced plasma levels of vitamin A are associated with ARDS and mortality.

NUTRIENTS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Janus Emulsion Biosensors for Anti-SARS-CoV-2 Spike Antibody

Jie Li et al.

Summary: The study presents a method using Janus emulsions as biosensors for detecting anti-SARS-CoV-2 spike antibodies, with agglutination assays detecting the antibodies' binding to specific proteins. The method shows good sensitivity and specificity in clinical samples and has the potential for detecting other analytes through attaching different biomolecular recognition elements to the Janus droplets' surface.

ACS CENTRAL SCIENCE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

Ernst Emmanuel Etienne et al.

Summary: COVID-19, a novel respiratory virus, presents challenges in testing due to its unique structure. While RT-PCR is the gold standard for viral testing, it has drawbacks in quantitative detection and result turnaround time. New detection methods are being developed with lower limits of detection and faster response times.

BIOENGINEERING-BASEL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19

Ayusha Poudel et al.

Summary: This study found that admission D-dimer value is an accurate biomarker for predicting mortality in patients with COVID-19, with an optimal cutoff value of 1.5 mu g/ml.

PLOS ONE (2021)

添加到收藏夹

Article Biochemical Research Methods

A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection

Dan Liu et al.

Summary: The MI-IF-RPA assay developed in this study offers a rapid and sensitive detection of SARS-CoV-2, integrating RT-RPA and LF detection systems into a single microfluidic chip. The assay provides easily interpretable results with a short testing time of approximately 30 minutes, showing high sensitivity and specificity, making it a cost-effective screening tool for resource-limited areas in complement to RT-PCR.

LAB ON A CHIP (2021)

添加到收藏夹

Article Chemistry, Analytical

Colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a visual diagnostic platform for the detection of the emerging coronavirus SARS-CoV-2

Kawin Nawattanapaiboon et al.

Summary: This study developed a visual diagnostic platform for SARS-CoV-2 based on colorimetric RT-LAMP with sensitivity and specificity comparable to commercial qRT-PCR assays. The method showed high accuracy and reliability in clinical specimens, indicating its potential beneficial use as a diagnostic platform for COVID-19 screening.

ANALYST (2021)

添加到收藏夹

Review Cell Biology

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

Ioannis P. Trougakos et al.

Summary: The article discusses the two-phase nature of COVID-19, highlighting the characteristics of increased virus transmission and uncontrolled inflammatory immune responses which can lead to severe complications. The focus is on approaches to suppress viral infection rates, activate adaptive immune responses, and mitigate tissue damage and cytokine storms associated with COVID-19.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

添加到收藏夹

Review Virology

Diagnostic accuracy of serological tests and kinetics of severe acute respiratory syndrome coronavirus 2 antibody: A systematic review and meta-analysis

Daniel Mekonnen et al.

Summary: This study evaluated the diagnostic test accuracy of SARS-COV-2 serological tests and the kinetics of antibody positivity through systematic review and meta-analysis. Results showed that CLIA assays targeting antibodies against RBD had the highest sensitivity and varied over time. The antibody positivity rate increased with days post-symptom onset, but decreased when transitioning from acute phase to convalescent phase.

REVIEWS IN MEDICAL VIROLOGY (2021)

添加到收藏夹

Letter Medical Laboratory Technology

Laboratory abnormalities in patients with COVID-2019 infection

Giuseppe Lippi et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

添加到收藏夹

Article Infectious Diseases

Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system

Susanne Pfefferle et al.

EUROSURVEILLANCE (2020)

添加到收藏夹

Letter Critical Care Medicine

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Qiurong Ruan et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Article Virology

Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis

Zhengtu Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

Jasper Fuk-Woo Chan et al.

LANCET (2020)

添加到收藏夹

Article Infectious Diseases

Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study

Heshui Shi et al.

LANCET INFECTIOUS DISEASES (2020)

添加到收藏夹

Editorial Material Infectious Diseases

Convalescent plasma as a potential therapy for COVID-19

Long Chen et al.

LANCET INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection

Guangyu Qiu et al.

ACS NANO (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles

Parikshit Moitra et al.

ACS NANO (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Diagnosing COVID-19: The Disease and Tools for Detection

Buddhisha Udugama et al.

ACS NANO (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor

Giwan Seo et al.

ACS NANO (2020)

添加到收藏夹

Article Biophysics

Ultra-sensitive and high-throughput CRISPR-p owered COVID-19 diagnosis

Zhen Huang et al.

BIOSENSORS & BIOELECTRONICS (2020)

添加到收藏夹

Review Immunology

Current status of potential therapeutic candidates for the COVID-19 crisis

Jiancheng Zhang et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

添加到收藏夹

Article Medical Laboratory Technology

Potential False-Negative Nucleic Acid Testing Results for Severe Acute Respiratory Syndrome Coronavirus 2 from Thermal Inactivation of Samples with Low Viral Loads

Yang Pan et al.

CLINICAL CHEMISTRY (2020)

添加到收藏夹

Article Immunology

Antibody Detection and Dynamic Characteristics in Patients With Coronavirus Disease 2019

Fei Xiang et al.

CLINICAL INFECTIOUS DISEASES (2020)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review

Zheng Ye et al.

EUROPEAN RADIOLOGY (2020)

添加到收藏夹

Article Chemistry, Analytical

Development of a Portable, Ultra-Rapid and Ultra-Sensitive Cell-Based Biosensor for the Direct Detection of the SARS-CoV-2 S1 Spike Protein Antigen

Sophie Mavrikou et al.

SENSORS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Development of Point-of-Care Biosensors for COVID-19

Jane Ru Choi

FRONTIERS IN CHEMISTRY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

CRISPR-Cas12-based detection of SARS-CoV-2

James P. Broughton et al.

NATURE BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

RT-LAMP for rapid diagnosis of coronavirus SARS-CoV-2

Wei E. Huang et al.

MICROBIAL BIOTECHNOLOGY (2020)

添加到收藏夹

Article Chemistry, Analytical

Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min

Qiuyuan Lin et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Portable chest X-ray in coronavirus disease-19 (COVID-19): A pictorial review

Adam Jacobi et al.

CLINICAL IMAGING (2020)

添加到收藏夹

Review Medical Laboratory Technology

Biomarkers associated with COVID-19 disease progression

Giovanni Ponti et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Biosensors: frontiers in rapid detection of COVID-19

Rachel Samson et al.

3 BIOTECH (2020)

添加到收藏夹

Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Virology

Evaluation of rapid antigen test for detection of SARS-CoV-2 virus

Gannon C. K. Mak et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

添加到收藏夹

Article Biochemical Research Methods

Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients

Christian Ihling et al.

JOURNAL OF PROTEOME RESEARCH (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The role of biomarkers in diagnosis of COVID-19-A systematic review

Muhammed Kermali et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Cell Biology

A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples

Viet Loan Dao Thi et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections

Huibin Lv et al.

CELL REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR

Ioanna Smyrlaki et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Engineering, Biomedical

Emerging diagnostic tools for detection of COVID-19 and perspective

Nidhi Verma et al.

BIOMEDICAL MICRODEVICES (2020)

添加到收藏夹

Article Biophysics

Detection of antibodies against SARS-CoV-2 spike protein by gold nanospikes in an opto-microfluidic chip

Riccardo Funari et al.

BIOSENSORS & BIOELECTRONICS (2020)

添加到收藏夹

Article Biophysics

Facile biosensors for rapid detection of COVID-19

Lizhou Xu et al.

BIOSENSORS & BIOELECTRONICS (2020)

添加到收藏夹

Article Virology

Comparison of Rapid Antigen Tests for COVID-19

Seiya Yamayoshi et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

On the Challenges for the Diagnosis of SARS-CoV-2 Based on a Review of Current Methodologies

Isabela A. Mattioli et al.

ACS SENSORS (2020)

添加到收藏夹

Article Infectious Diseases

Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study

Malick M. Gibani et al.

LANCET MICROBE (2020)

添加到收藏夹

Review Nanoscience & Nanotechnology

Point-of-Care Biosensor-Based Diagnosis of COVID-19 Holds Promise to Combat Current and Future Pandemics

Arpana Parihar et al.

ACS APPLIED BIO MATERIALS (2020)

添加到收藏夹

Article Virology

Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand

Chutikarn Chaimayo et al.

VIROLOGY JOURNAL (2020)

添加到收藏夹

Review Chemistry, Analytical

Nanobiosensors as new diagnostic tools for SARS, MERS and COVID-19: from past to perspectives

Riccarda Antiochia

MICROCHIMICA ACTA (2020)

添加到收藏夹

Review Endocrinology & Metabolism

A review of modern technologies for tackling COVID-19 pandemic

Aishwarya Kumar et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

添加到收藏夹

Article Immunology

Detection of IgM and IgG antibodies in patients with coronavirus disease 2019

Hongyan Hou et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

添加到收藏夹

Letter Tropical Medicine

Coronavirus disease-2019: is fever an adequate screening for the returning travelers?

George M. Bwire et al.

TROPICAL MEDICINE AND HEALTH (2020)

添加到收藏夹

Article Infectious Diseases

A rapid and sensitive recombinase aided amplification assay to detect hepatitis B virus without DNA extraction

Xin-xin Shen et al.

BMC INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Engineering, Biomedical

Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor

Reza Hajian et al.

NATURE BIOMEDICAL ENGINEERING (2019)

添加到收藏夹

Review Biophysics

Immunosensor-based label-free and multiplex detection of influenza viruses: State of the art

Hanyuan Zhang et al.

BIOSENSORS & BIOELECTRONICS (2019)

添加到收藏夹

Review Virology

Coronavirus genomic RNA packaging

Paul S. Masters

VIROLOGY (2019)

添加到收藏夹

Article Infectious Diseases

Use of a rapid reverse-transcription recombinase aided amplification assay for respiratory syncytial virus detection

Chen Chen et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen et al.

SCIENCE (2018)

添加到收藏夹

Review Chemistry, Analytical

Recombinase polymerase amplification: Basics, applications and recent advances

Ivan Magrina Lobato et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2018)

添加到收藏夹

Letter Cell Biology

CRISPR-Cas12a-assisted nucleic acid detection

Shi-Yuan Li et al.

CELL DISCOVERY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg et al.

SCIENCE (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

Mahmoud Labib et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Article Biochemical Research Methods

Influence of sequence mismatches on the specificity of recombinase polymerase amplification technology

Rana K. Daher et al.

MOLECULAR AND CELLULAR PROBES (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Rapid Detection of Shrimp White Spot Syndrome Virus by Real Time, Isothermal Recombinase Polymerase Amplification Assay

Xiaoming Xia et al.

PLOS ONE (2014)

添加到收藏夹

Article Microbiology

Rapid Detection of HIV-1 Proviral DNA for Early Infant Diagnosis Using Recombinase Polymerase Amplification

David S. Boyle et al.

MBIO (2013)

添加到收藏夹

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

添加到收藏夹

Review Infectious Diseases

Loop-mediated isothermal amplification (LAMP): a rapid, accurate, and cost-effective diagnostic method for infectious diseases

Yasuyoshi Mori et al.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2009)

添加到收藏夹

Article Biochemical Research Methods

Accelerated reaction by loop-mediated isothermal amplification using loop primers

K Nagamine et al.

MOLECULAR AND CELLULAR PROBES (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Loop-mediated isothermal amplification of DNA

Tsugunori Notomi et al.

NUCLEIC ACIDS RESEARCH (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.