期刊
JOURNAL OF MICROENCAPSULATION
卷 33, 期 6, 页码 563-568出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02652048.2016.1225844
关键词
Chitosan; salicylic acid; poly(2-hydroxyethyl methacrylate); core-shell; drug delivery; microgel
资金
- Mahidol University
- Center of Excellence for Innovation in Chemistry (PERCH-CIC), the Office of Higher Education Commission, Ministry of Education, Thailand
This work presents the evaluation of chitosan-functionalised poly(2-hydroxyethyl methacrylate) (CS/PHEMA) core-shell microgels as drug delivery carriers. CS/PHEMA microgels were prepared by emulsifier-free emulsion polymerisation with N,N-methylenebisacrylamide (MBA) as a crosslinker. The study on drug loading, using salicylic acid (SA) as a model drug, was performed. The results showed that the encapsulation efficiency (EE) increased as drug-to-microgel ratio was increased. Higher EE can be achieved with the increase in degree of crosslinking, by increasing the amount of MBA from 0.01g to 0.03g. In addition, the highest EE (61.1%) was observed at pH 3. The highest release of SA (60%) was noticed at pH 2.4, while the lowest one (49.4%) was obtained at pH 7.4. Moreover, the highest release of SA was enhanced by the presence of 0.2 M NaCl. The pH- and ionic-sensitivity of CS/PHEMA could be useful as a sustained release delivery device, especially for oral delivery.
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