Novel Pumping Methods for Microfluidic Devices: A Comprehensive Review

Article Biophysics

Microfluidic device for one-step detection of breast cancer-derived exosomal mRNA in blood using signal-amplifiable 3D nanostructure

Jaewoo Lim et al.

Summary: The newly developed exoNA-sensing chip, based on microfluidic and 3D-nanostructured hydrogels, allows for rapid detection of ERBB2 with high accuracy and selectivity.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Biochemistry & Molecular Biology

Microfluidic-Based Technologies for CTC Isolation: A Review of 10 Years of Intense Efforts towards Liquid Biopsy

Lucie Descamps et al.

Summary: The selection of circulating tumor cells (CTCs) from blood as a real-time liquid biopsy has gained attention for its potential in research and clinical applications. Microfluidic-based isolation technologies have emerged as promising tools to overcome the technical challenges posed by the rarity and heterogeneity of CTCs. This review provides an overview of the latest microfluidic devices implemented for CTC isolation, highlighting the tradeoff between recovery and purity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biophysics

A capillary driven microfluidic chip for SERS based hCG detection

Elcin Ezgi Ahi et al.

Summary: This study developed a capillary driven microfluidic chip-based immunoassay for the determination of prohibited hCG protein. The method showed high selectivity and accuracy in detecting various proteins, with a regression coefficient of 0.9985 and a limit of detection of 0.61 IU/L. The analysis system developed for target proteins could serve as an alternative to traditional methods such as Western Blot, offering a more cost-effective and time-saving solution.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Hand-powered vacuum-driven microfluidic gradient generator for high-throughput antimicrobial susceptibility testing

Wenyi Zeng et al.

Summary: The article introduces a hand-powered vacuum-driven microfluidic device that can rapidly generate concentration gradients of different antibiotics for antibiotic susceptibility testing. The device is easy to operate, with advantages such as high throughput, cost efficiency, and shortened detection time.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Environmental Sciences

Development of a proof-of-concept microfluidic portable pathogen analysis system for water quality monitoring

Hamsa N. Gowda et al.

Summary: The study developed a portable pathogen analysis system that can detect bacteria in water within 1 hour, with the advantages of simple operation and high sensitivity.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Chemistry, Analytical

Recent Advances in Thermoplastic Microfluidic Bonding

Kiran Giri et al.

Summary: This review paper summarizes the bonding processes for thermoplastic microfluidic devices and compares different bonding strategies to assist researchers in finding suitable bonding methods for microfluidic device assembly.

MICROMACHINES (2022)

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Review Chemistry, Analytical

Recent Advances in Microfluidic Platform for Physical and Immunological Detection and Capture of Circulating Tumor Cells

Mahesh Padmalaya Bhat et al.

Summary: CTCs, circulating tumor cells, are widely used in clinical trials for tumor diagnosis, and capturing and isolating CTCs from whole blood samples has significant benefits in cancer diagnosis and treatment. Traditional methods are time-consuming and face challenges, while recent advances in microfluidic devices offer higher efficiency and accuracy in capturing and isolating CTCs.

BIOSENSORS-BASEL (2022)

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Review Chemistry, Analytical

Recent advances in microfluidic devices for foodborne pathogens detection

Dan Gao et al.

Summary: Rapid and accurate detection of foodborne pathogens is crucial for preventing outbreaks of foodborne diseases. Conventional detection methods are not suitable for on-site detection due to their cumbersome operations and requirement for trained operators and sophisticated instruments. Microfluidics, with its advantages of easy integration, miniaturization, portability, and small sample consumption, provides a powerful tool for pathogen detection. This review summarizes the significant developments in microfluidic-based devices for detecting pathogenic bacteria over the past five years, including integration of sample preparation techniques, various detection methods, and microfluidic paper-based analytical devices. The limitations and advantages of these methods are discussed, and the future challenges and directions for pathogen detection based on microfluidic biosensors are also highlighted.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

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Article Biochemical Research Methods

Centrifugal disc liquid reciprocation flow considerations for antibody binding to COVID antigen array during microfluidic integration

Alexander T. Hwu et al.

Summary: This study investigated the liquid reciprocation process on a microfluidic centrifugal disc (CD), achieving continuous and bidirectional flow. The flow shear rates were determined experimentally and through simulation, and it was found that higher shear rates negatively affected fluorescence intensity. The importance of proper fluid flow considerations when integrating heterogeneous immunoassays (HI) with microfluidics was highlighted.

LAB ON A CHIP (2022)

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Article Nanoscience & Nanotechnology

A practical microfluidic pump enabled by acoustofluidics and 3D printing

Adem Ozcelik et al.

Summary: A simple and low-cost microfluidic pumping device utilizing 3D printing and acoustofluidics technology has been developed, offering controllable and continuous flow rates for on-chip sample processing and analysis. The device achieves a maximum flow rate of around 12 μL/min and allows for control of pumping direction by frequency tuning, providing a promising solution for portable, affordable, and reliable fluid manipulation in on-chip applications.

MICROFLUIDICS AND NANOFLUIDICS (2021)

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Article Engineering, Biomedical

CMOS-Based Electrokinetic Microfluidics With Multi-Modal Cellular and Bio-Molecular Sensing for End-to-End Point-of-Care System

Chengjie Zhu et al.

Summary: This research addresses the issue of bulk fluid processing in point-of-care diagnostics by using AC osmotic based electrokinetic fluid flows controlled by CMOS ICs, enabling miniaturization of end-to-end systems. By combining bulk fluid flow control with bio-molecular sensing, cell manipulation, cytometry, and separation using silicon chips, a comprehensive bio-sensing device has been achieved.

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (2021)

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Article Multidisciplinary Sciences

Cancer cell enrichment on a centrifugal microfluidic platform using hydrodynamic and magnetophoretic techniques

Amir Shamloo et al.

Summary: The study focused on isolating rare cancer cells using two centrifugal microfluidic devices. The passive design isolates cells through inertial effects and bifurcation law, while the hybrid design captures magnetically labeled cells using permanent magnets at the end of the microchannel. The hybrid design offers better separation efficiency and purity, while the passive one is simpler and cost-effective without the need for cell labeling.

SCIENTIFIC REPORTS (2021)

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Review Biotechnology & Applied Microbiology

Microfluidic Point-of-Care Testing: Commercial Landscape and Future Directions

Shivangi Sachdeva et al.

Summary: POCT allows physicians to detect and diagnose diseases faster than conventional lab-based testing, with particular importance in the COVID-19 pandemic. There are various point-of-care tests and diagnostic devices available in the market, including glucose monitoring, pregnancy testing, and infectious disease testing.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Food Science & Technology

Advances in microfluidic nanobiosensors for the detection of foodborne pathogens

Xuan Weng et al.

Summary: Rapid and accurate detection of foodborne pathogens is crucial for preventing outbreaks, and microfluidic nanobiosensors show promise in achieving this by reducing assay time, enhancing sensitivity, and improving accuracy.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Engineering, Electrical & Electronic

Design and development of a microfluidic droplet generator with vision sensing for lab-on-a-chip devices

Samith Hettiarachchi et al.

Summary: This paper discusses the modeling, simulation, and experimentation of an active droplet generator used in LOC devices, focusing on the key factor of droplet generation. The study found that optimized droplet contraction width and flow rate ratios are crucial for effective droplet generation. Experimental results show that droplet formation occurs within a certain range of flow rate ratios, with droplet diameter decreasing as the flow rate ratio decreases.

SENSORS AND ACTUATORS A-PHYSICAL (2021)

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Article Chemistry, Analytical

Integrated and finger-actuated microfluidic chip for point-of-care testing of multiple pathogens

Peng Chen et al.

Summary: The integration of gLAMP and mu FAchip allows for simultaneous detection of different types of bacterial pathogens. The developed mu FAchip features a simple operation process with high specificity and sensitivity, making it a rapid and effective platform for pathogen detection, especially in field settings.

TALANTA (2021)

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Article Multidisciplinary Sciences

Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism

Yushen Zhang et al.

Summary: State-of-the-art microfluidic systems are inaccessible to DIY community or enthusiasts due to expensive off-chip infrastructures. 3D-printing shows promise in simplifying microfluidic chip fabrication, but limitations exist in terms of chip hardness and single-layered design. Innovative active control mechanisms for fluids are being developed with air or gas interception to enable portable, user-programmed experiments in microfluidics.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

Gravity-Driven Microfluidic Siphons: Fluidic Characterization and Application to Quantitative Immunoassays

Nuno M. Reis et al.

Summary: A range of biosensing techniques, including immunoassays, are used for quantitation of analytes in biological samples. High analytical performance is linked to the use of reagent and washing steps, which can be challenging to deliver in point-of-care testing without a high level of fluidic control.

ACS SENSORS (2021)

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Review Engineering, Mechanical

A review on microdroplet generation in microfluidics

Wenbo Han et al.

Summary: Micro-nanofluidic technology is widely used in various fields such as food safety testing, drug screening, new material synthesis, and bioengineering. The development of droplet microfluidic technology has overcome many challenges of continuous flow technology and is expected to be an important direction for future research.

JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING (2021)

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Article Chemistry, Analytical

An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution

Anyang Wang et al.

Summary: An integrated serial dilution generator utilizing centrifugal force and vacuum-driven force was proposed, allowing for easy adjustment of dilution ratio and chamber volume by changing the geometrical designs of the device. The device was used for sample metering and transferring, as well as sample loading and mixing, with successful preparation of ten-fold serial dilutions and good agreement with manually prepared samples in subsequent analysis.

MICROMACHINES (2021)

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Article Nanoscience & Nanotechnology

Pressure-driven generation of complex microfluidic droplet networks

Tayler M. Schimel et al.

Summary: This paper presents a pressure-driven microfluidic system for rapid generation of DIB networks, each consisting of four droplets, enabling complex droplet patterning for biological assays. The system allows for control of droplet production rates and trap design to form interfacial lipid bilayers, providing high-throughput generation of DIB networks.

MICROFLUIDICS AND NANOFLUIDICS (2021)

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Article Chemistry, Multidisciplinary

Finger-Actuated Microneedle Array for Sampling Body Fluids

Misagh Rezapour Sarabi et al.

Summary: The application of microneedles for minimally invasive biological fluid sampling offers a user-friendly and less painful approach compared to conventional needles. The finger-powered microneedle array integrated with a microfluidic chip enables efficient and simple collection of body fluids without the need for healthcare workers, making it ideal for personalized medical equipment.

APPLIED SCIENCES-BASEL (2021)

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Article Chemistry, Multidisciplinary

Pump-Free Microfluidic Device for the Electrochemical Detection of α1-Acid Glycoprotein

Tania Sierra et al.

Summary: A pump-free microfluidic device for the electrochemical determination of AGP was proposed and demonstrated to be successful. The device allows all analytical steps to be carried out inside, with a wide linear range, low detection limit, and applicability to commercial serum samples.

ACS SENSORS (2021)

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Article Chemistry, Multidisciplinary

Mixing during Trapping Enabled a Continuous-Flow Microfluidic Smartphone Immunoassay Using Acoustic Streaming

Xian Chen et al.

Summary: A novel acoustic streaming tweezers-enabled microfluidic immunoassay was proposed, allowing for probe particles' purification, reaction, and sensing on the same chip under continuous-flow conditions. The high-speed microscale vortexes enable dynamic trapping and washing of the probe particles and enhance the capture efficiency of heterogeneous particle-based immunoassay through active mixing during trapping. This system achieved a limit of detection of 0.2 ng/mL and a dynamic response range from 0.3 to 10 ng/mL for prostate-specific antigen sensing with only 10 μL of sample in less than 15 minutes total assay time, making it suitable for on-site diagnosis applications.

ACS SENSORS (2021)

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Article Biochemical Research Methods

A vacuum-assisted, highly parallelized microfluidic array for performing multi-step digital assays

Jiumei Hu et al.

Summary: This study presents a PDMS-based vacuum-driven microfluidic array capable of multi-step sample loading and digitization. The array demonstrates high uniformity and anti-evaporation design, making it suitable for single-molecule and single-cell analyses.

LAB ON A CHIP (2021)

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Review Nanoscience & Nanotechnology

Novel microfluidic approaches to circulating tumor cell separation and sorting of blood cells: A review

A. Farahinia et al.

Summary: The separation of circulating tumor cells (CTCs) is crucial for cancer diagnostics, progression analyses, and treatment efficiency. Researchers are exploring various techniques for quick and continuous CTC separation, with inertial microfluidic devices showing promise for their simple structure and setup. However, challenges like the need for pumps, limited cell movement control, and channel clogging still exist.

JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES (2021)

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Article Biochemical Research Methods

Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out

Ruben R. G. Soares et al.

Summary: This study aimed to develop a cost-effective viral load detection system for point-of-care COVID-19 diagnostics. By developing an integrated modular centrifugal microfluidic platform, rapid amplification and detection of viral RNA from nasopharyngeal swab samples with high specificity and sensitivity were achieved.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows†

H. Azizgolshani et al.

Summary: Drug development lacks predictive and human-relevant in vitro models. The Organ-on-chip (OOC) technology provides advanced culture capabilities to generate human-based tissue in vitro, but faces challenges in throughput and compatibility. This study presents an OOC platform with advanced culture capabilities supporting multiple human tissue models for drug screening and gene expression analysis.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

Integrated microfluidic platform with electrohydrodynamic focusing and a carbon-nanotube-based field-effect transistor immunosensor for continuous, selective, and label-free quantification of bacteria

Chang-Ho Han et al.

Summary: An immunosensor utilizing electrohydrodynamic focusing and DEP concentration was developed for continuous and label-free detection of flowing Staphylococcus aureus. The sensor demonstrated good linearity in detecting S. aureus concentrations, with a capture time of 35 min and a limit of detection of 150 CFU mL(-1). The use of electrical manipulation and biological interaction also provided high specificity in measurements.

LAB ON A CHIP (2021)

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Review Chemistry, Multidisciplinary

Progress in Microfluidics-Based Exosome Separation and Detection Technologies for Diagnostic Applications

Shujing Lin et al.

SMALL (2020)

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Review Polymer Science

PDMS microfluidics: A mini review

Kiran M. Raj et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2020)

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Article Polymer Science

Capillary Microfluidic-Assisted Surface Structuring

Wei Li et al.

ACS MACRO LETTERS (2020)

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Review Biochemical Research Methods

Passive micropumping in microfluidics for point-of-care testing

Linfeng Xu et al.

BIOMICROFLUIDICS (2020)

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Review Biochemical Research Methods

Microfluidic applications on circulating tumor cell isolation and biomimicking of cancer metastasis

Xiawei Xu et al.

ELECTROPHORESIS (2020)

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Article Chemistry, Analytical

Hand-Powered Elastomeric Pump for Microfluidic Point-of-Care Diagnostics

Gangadhar Eluru et al.

MICROMACHINES (2020)

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Article Multidisciplinary Sciences

Image-Based Single Cell Sorting Automation in Droplet Microfluidics

Muhsincan Sesen et al.

SCIENTIFIC REPORTS (2020)

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Article Chemistry, Analytical

Acoustic Microfluidics

Peiran Zhang et al.

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 13 (2020)

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Article Chemistry, Analytical

Design and Fabrication of Capillary-Driven Flow Device for Point-Of-Care Diagnostics

Sammer-Ul Hassan et al.

BIOSENSORS-BASEL (2020)

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Article Mechanics

On the thin-film asymptotics of surface tension driven microfluidics

S. N. Calver et al.

JOURNAL OF FLUID MECHANICS (2020)

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Review Chemistry, Analytical

Nanotechnology-Assisted Isolation and Analysis of Circulating Tumor Cells on Microfluidic Devices

Jie Cheng et al.

MICROMACHINES (2020)

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Article Biotechnology & Applied Microbiology

Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Amal Essaouiba et al.

BIOCHEMICAL ENGINEERING JOURNAL (2020)

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Review Endocrinology & Metabolism

Pancreas-on-a-Chip Technology for Transplantation Applications

Shadab Abadpour et al.

CURRENT DIABETES REPORTS (2020)

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Article Biology

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

Vivek V. Thacker et al.

ELIFE (2020)

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Article Biochemical Research Methods

Gravity-driven microfluidic assay for digital enumeration of bacteria and for antibiotic susceptibility testing

Yu-Ting Kao et al.

LAB ON A CHIP (2020)

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Review Engineering, Biomedical

Disease diagnostics using hydrodynamic flow focusing in microfluidic devices: Beyond flow cytometry

Aakash Rajawat et al.

BIOMEDICAL ENGINEERING LETTERS (2020)

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Review Chemistry, Analytical

Paper Microfluidics for Point-of-Care Blood-Based Analysis and Diagnostics

Hua Li et al.

ANALYTICAL CHEMISTRY (2019)

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Review Biochemical Research Methods

New advances in microfluidic flow cytometry

Yanli Gong et al.

ELECTROPHORESIS (2019)

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Review Biochemical Research Methods

High-throughput microfluidic imaging flow cytometry

Stavros Stavrakis et al.

CURRENT OPINION IN BIOTECHNOLOGY (2019)

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Article Chemistry, Analytical

Rapid and Automated Detection of Six Contaminants in Milk Using a Centrifugal Microfluidic Platform with Two Rotation Axes

Yiqi Chen et al.

ANALYTICAL CHEMISTRY (2019)

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Article Engineering, Environmental

Droplet microfluidics with gravity-driven overflow system

Wei Gao et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Chemistry, Analytical

Bio-O-Pump: a novel portable microfluidic device driven by osmotic pressure

Chen-Han Chuang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Review Chemistry, Applied

Microfluidics and hydrogel: A powerful combination

Carla B. Goy et al.

REACTIVE & FUNCTIONAL POLYMERS (2019)

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Review Chemistry, Analytical

Blood Cells Separation and Sorting Techniques of Passive Microfluidic Devices: From Fabrication to Applications

Susana O. Catarino et al.

MICROMACHINES (2019)

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Article Chemistry, Analytical

Microfluidic Passive Flow Regulatory Device with an Integrated Check Valve for Enhanced Flow Control

Xinjie Zhang et al.

MICROMACHINES (2019)

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Article Chemistry, Multidisciplinary

Sample-to-Answer Hepatitis B Virus DNA Detection from Whole Blood on a Centrifugal Microfluidic Platform with Double Rotation Axes

Lei Li et al.

ACS SENSORS (2019)

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Review Microbiology

Microfluidic-Based Approaches for Foodborne Pathogen Detection

Xihong Zhao et al.

MICROORGANISMS (2019)

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Review Biochemical Research Methods

Spiral microfluidic devices for cell separation and sorting in bioprocesses

N. Herrmann et al.

BIOMICROFLUIDICS (2019)

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Article Multidisciplinary Sciences

A Low-Power CMOS Microfluidic Pump Based on Travelling-Wave Electroosmosis for Diluted Serum Pumping

Pei-Wen Yen et al.

SCIENTIFIC REPORTS (2019)

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Review Cell Biology

Organ-on-chip models: Implications in drug discovery and clinical applications

Rahul Mittal et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Engineering, Biomedical

Paper Microfluidics for Cell Analysis

Jun Ma et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Biochemical Research Methods

Automated microchannel alignment using innate opto-signature for microchip electrophoresis

Anchi Scott et al.

LAB ON A CHIP (2019)

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Article Biochemical Research Methods

Two-dimensional computational method for generating planar electrode patterns with enhanced volumetric electric fields and its application to continuous dielectrophoretic bacterial capture

Chang-Ho Han et al.

LAB ON A CHIP (2019)

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Article Biochemical Research Methods

Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device

Bee Luan Khoo et al.

NATURE PROTOCOLS (2018)

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Review Biochemical Research Methods

Microfluidics Based Point-of-Care Diagnostics

Chandra M. Pandey et al.

BIOTECHNOLOGY JOURNAL (2018)

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Article Biochemical Research Methods

A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function

Xiaolin Wang et al.

LAB ON A CHIP (2018)

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Review Biochemical Research Methods

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

Ayokunle Olanrewaju et al.

LAB ON A CHIP (2018)

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Article Biochemical Research Methods

Finger-actuated microfluidic device for the blood cross-matching test

Juhwan Park et al.

LAB ON A CHIP (2018)

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Article Nanoscience & Nanotechnology

A clip-on electroosmotic pump for oscillating flow in microfluidic cell culture devices

Katarina Bengtsson et al.

MICROFLUIDICS AND NANOFLUIDICS (2018)

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Article Chemistry, Analytical

Capillary-driven microfluidic device with integrated nanoporous microbeads for ultrarapid biosensing assays

Roberta t Epifania et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Review Biochemical Research Methods

Inertial Microfluidics-Based Cell Sorting

Ga-Yeong Kim et al.

BIOCHIP JOURNAL (2018)

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Article Engineering, Electrical & Electronic

Stand-alone external power-free microfluidic fuel cell system harnessing osmotic pump for long-term operation

Sung-Hwan Kim et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2018)

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Article Chemistry, Analytical

A Novel Microfluidic Point-of-Care Biosensor System on Printed Circuit Board for Cytokine Detection

Daniel Evans et al.

SENSORS (2018)

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Review Engineering, Multidisciplinary

Microfluidic flow cytometry: The role of microfabrication methodologies, performance and functional specification

Anil B. Shrirao et al.

TECHNOLOGY (2018)

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Article Engineering, Chemical

Forward osmosis membranes with unprecedented water flux

Hong-Qing Liang et al.

JOURNAL OF MEMBRANE SCIENCE (2017)

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Review Biochemical Research Methods

Passive and active droplet generation with microfluidics: a review

Pingan Zhu et al.

LAB ON A CHIP (2017)

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Article Multidisciplinary Sciences

Low-cost feedback-controlled syringe pressure pumps for microfluidics applications

John R. Lake et al.

PLOS ONE (2017)

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Article Chemistry, Analytical

Comprehensive Study of the Flow Control Strategy in a Wirelessly Charged Centrifugal Microfluidic Platform with Two Rotation Axes

Yunzeng Zhu et al.

ANALYTICAL CHEMISTRY (2017)

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Review Chemistry, Multidisciplinary

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

Joshua M. Jackson et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Biotechnology & Applied Microbiology

High-Throughput Single-Cell Cultivation on Microfluidic Streak Plates

Cheng-Ying Jiang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

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Article Engineering, Biomedical

A pumpless microfluidic device driven by surface tension for pancreatic islet analysis

Yuan Xing et al.

BIOMEDICAL MICRODEVICES (2016)

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Article Biochemical Research Methods

Microfluidics made easy: A robust low-cost constant pressure flow controller for engineers and cell biologists

Nicholas Mavrogiannis et al.

BIOMICROFLUIDICS (2016)

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Review Biotechnology & Applied Microbiology

Advances in microfluidics in combating infectious diseases

Andy Tay et al.

BIOTECHNOLOGY ADVANCES (2016)

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Article Biochemical Research Methods

Surface-tension driven open microfluidic platform for hanging droplet culture

T. E. de Groot et al.

LAB ON A CHIP (2016)

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Review Biochemical Research Methods

Active droplet generation in microfluidics

Zhuang Zhi Chong et al.

LAB ON A CHIP (2016)

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Article Chemistry, Analytical

A stand-alone pressure-driven 3D microfluidic chemical sensing analytic device

Jae-Ho Shin et al.

SENSORS AND ACTUATORS B-CHEMICAL (2016)

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Review Chemistry, Analytical

Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production

Chia-Wen Tsao

MICROMACHINES (2016)

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Article Multidisciplinary Sciences

Automated Chemotactic Sorting and Single-cell Cultivation of Microbes using Droplet Microfluidics

Libing Dong et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemical Research Methods

Phaseguide-assisted blood separation microfluidic device for point-of-care applications

Linfeng Xu et al.

BIOMICROFLUIDICS (2015)

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Article Biochemical Research Methods

A self-powered one-touch blood extraction system: a novel polymer-capped hollow microneedle integrated with a pre-vacuum actuator

Cheng Guo Li et al.

LAB ON A CHIP (2015)

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Review Biochemical Research Methods

Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

C. Wyatt Shields et al.

LAB ON A CHIP (2015)

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Article Multidisciplinary Sciences

Acoustic separation of circulating tumor cells

Peng Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Chemistry, Analytical

Self-propelled continuous-flow PCR in capillary-driven microfluidic device: Microfluidic behavior and DNA amplification

Hiroaki Tachibana et al.

SENSORS AND ACTUATORS B-CHEMICAL (2015)

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Article Biophysics

Integrated optical detection of autonomous capillary microfluidic immunoassays:a hand-held point-of-care prototype

P. Novo et al.

BIOSENSORS & BIOELECTRONICS (2014)

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Review Biochemical Research Methods

Pumps for microfluidic cell culture

Chang Kyu Byun et al.

ELECTROPHORESIS (2014)

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