Novel Pumping Methods for Microfluidic Devices: A Comprehensive Review

This review is an account of methods that use various strategies to control microfluidic flow control with high accuracy. The reviewed systems are divided into two large groups based on the way they create flow: passive systems (non-mechanical systems) and active (mechanical) systems. Each group is presented by a number of device fabrications. We try to explain the main principles of operation, and we list advantages and disadvantages of the presented systems. Mechanical systems are considered in more detail, as they are currently an area of increased interest due to their unique precision flow control and multitasking. These systems are often applied as mini-laboratories, working autonomously without any additional operations, provided by humans, which is very important under complicated conditions. We also reviewed the integration of autonomous microfluidic systems with a smartphone or single-board computer when all data are retrieved and processed without using a personal computer. In addition, we discuss future trends and possible solutions for further development of this area of technology.

Automated summary

This review discusses methods for controlling microfluidic flow with high accuracy using various strategies. The systems are divided into two groups - passive and active - based on their flow creation mechanisms. The operation principles, advantages, and disadvantages of each group are explained. The focus is on mechanical systems, which are of particular interest due to their precision flow control and autonomous operation. The integration of autonomous microfluidic systems with smartphones or single-board computers, as well as future trends and potential developments in the field, are also discussed.