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Nanoplastics and Microplastics May Be Damaging Our Livers

TOXICS (2022)

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Article Environmental Sciences

The effects of exposure to microplastics on grass carp (Ctenopharyngodon idella) at the physiological, biochemical, and transcriptomic levels

Yang Liu et al.

Summary: The study found that grass carp exposed to microplastics exhibited liver cytoplasmic vacuolation and inhibited growth, as well as suppression of the antioxidant system and enhancement of oxidative stress. Transcriptome analysis revealed differentially expressed genes related to energy metabolism pathways and PPAR signaling pathway.

CHEMOSPHERE (2022)

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Article Environmental Sciences

Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats

Ali Akbar Babaei et al.

Summary: This study found that exposure to polystyrene nanoplastics can lead to oxidative stress and physiological changes in male rats, including an increase in reactive oxygen species, alterations in antioxidant responses, and changes in biochemical parameters. The results suggest possible neurobehavioral effects, dysfunctions in energy metabolism, and kidney dysfunction associated with exposure conditions. Further research with a larger sample size is needed to validate these findings.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Environmental Sciences

Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice

Ling Li et al.

Summary: Polystyrene nanoparticles exacerbate chronic hepatitis and interfere with liver lipid metabolism in high fat diet-induced mice, leading to increased oxidative stress and inflammation responses, consequently aggravating liver fibrosis.

ENVIRONMENTAL TOXICOLOGY (2022)

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Article Engineering, Environmental

Polystyrene microplastics induced female reproductive toxicity in mice

Zhiqiang Liu et al.

Summary: This study revealed that PS-MPs exposure in female mice led to accumulation in various organs and tissues, increased inflammation in ovaries, and reduced the quality of oocytes by affecting biochemical markers and cellular processes. These findings provide important insights into the reproductive toxic effects of plastic microplastics on female mammals.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Environmental Sciences

Sub-acute exposure to nanoplastics via two-chain trophic transfer: From brine shrimp Artemia franciscana to small yellow croaker Larimichthys polyactis

Lia Kim et al.

Summary: This study examined the transfer of nanoplastics in marine food chains. The results showed that fish exposed to nanoplastics through trophic transfer experienced inhibited growth, severe liver damage, and decreased swimming ability. The study suggested that even indirect exposure to nanoplastics can have neurotoxic effects and affect the swimming ability of fish. Considering that fish are a well-known food resource for humans, the possibility of these trophic transfers affecting higher trophic level organisms, such as humans, cannot be ignored.

MARINE POLLUTION BULLETIN (2022)

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Article Biochemistry & Molecular Biology

Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus)

Chunling Wang et al.

Summary: Microplastic exposure caused various sublethal effects on rare minnows, including cellular and tissue alterations in the liver. Transcriptomic and metabolomic analyses revealed significantly varied metabolic pathways, such as glucolipid, amino acid, and nucleotide metabolism. Results showed that microplastic exposure induced immune reaction, oxidative stress, and disturbed glycolipid and energy metabolism in rare minnows.

MOLECULES (2022)

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Article Toxicology

Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway

Haibo Jin et al.

Summary: Chronic exposure to microplastics can lead to reproductive abnormalities in mammals, including changes in testicular morphology, abnormal spermatogenesis, and interference with hormone secretion in the serum.

PARTICLE AND FIBRE TOXICOLOGY (2022)

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Article Environmental Sciences

Polystyrene nanoplastics affect digestive function and growth in juvenile groupers

Qing Wang et al.

Summary: The study showed that marine polystyrene nanoplastics (PS-NPs) have a negative impact on the digestive system of juvenile fish, leading to decreased digestive enzyme activities, altered microbial community composition, and a significant decrease in growth rate.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

Yingwen Mu et al.

Summary: The study shows that microplastics can damage the liver structure and function in mice, leading to inflammation and oxidative damage, and triggering processes of pyroptosis and ferroptosis.

CHEMOSPHERE (2022)

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Article Environmental Sciences

Immunotoxicity responses to polystyrene nanoplastics and their related mechanisms in the liver of zebrafish (Danio rerio) larvae

Haodong Cheng et al.

Summary: Nanoplastics in aquatic environments can have adverse immunotoxicity effects on fish, specifically impacting the liver function and immune system of fish larvae. Smaller particles induce higher aggregation of neutrophils and apoptosis of macrophages in the larvae, leading to greater hepatic inflammation. Additionally, the metabolic pathways of catabolic processes, amino acids, and purines are highly promoted by nanoparticles, while steroid hormone biosynthesis is activated in zebrafish larvae.

ENVIRONMENT INTERNATIONAL (2022)

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Article Environmental Sciences

Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway

Rong Shen et al.

Summary: This study provides valuable insights into the potential risk and mechanism of hepatic toxicity and fibrosis induced by microplastics. It demonstrates that even at low concentrations, microplastics can enter hepatocytes and cause liver damage. Microplastic exposure results in DNA damage and inflammation, leading to liver fibrosis. Moreover, inhibiting the relevant signaling pathway can alleviate liver fibrosis.

ENVIRONMENTAL POLLUTION (2022)

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Article Environmental Sciences

Increased transfer of trace metals and Vibrio sp. from biodegradable microplastics to catfish Clarias gariepinus

Faddrine Holt Jang et al.

Summary: This study aimed to quantify the transfer of trace metals from microplastics to catfish and assess its impact on the host's microbiome. The results showed that biodegradable polylactic acid transferred more metals to catfish and increased Vibrio counts in the intestines compared to polyamide 12. Trace metal accumulation was highest in the gills, followed by the liver, intestines, and edible muscles. Additionally, the study highlights the potential environmental threat posed by biodegradable polymers.

ENVIRONMENTAL POLLUTION (2022)

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Article Environmental Sciences

Autophagic event and metabolomic disorders unveil cellular toxicity of environmental microplastics on marine polychaete Hediste diversicolor*

Omayma Missawi et al.

Summary: This study evaluates the impact of different environmental microplastics (MPs) collected from the south coast of the Mediterranean Sea on the metabolome and proteome of the marine polychaete Hediste diversicolor. The results show that MPs cause cytoskeleton damage and induce abnormal autophagy pathway in polychaetes. Metabolomics analysis reveals altered metabolic profiles in polychaetes treated with MPs, with elevated levels of amino acids, glucose, and other substances, and reduced concentration of aspartate.

ENVIRONMENTAL POLLUTION (2022)

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Article Fisheries

Interactions effects of nano-microplastics and heavy metals in hybrid snakehead (Channa maculata ♀ x Channa argus ♂ )

Shaodan Wang et al.

Summary: This experiment investigated the interactions and effects of nano-microplastics with heavy metals cadmium in hybrid snakehead. Results showed that nano-microplastics and cadmium influenced the morphology of gills, caused oxidative damage to fish liver, and affected the activities of antioxidant enzymes as well as the expression of genes related to inflammation and metal accumulation.

FISH & SHELLFISH IMMUNOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

PET Tracing of Biodistribution for Orally Administered 64Cu-Labeled Polystyrene in Mice

Changkeun Im et al.

Summary: Plastics have become widely used due to their convenience and cost effectiveness, but their degradation poses a threat to the environment and human health. This study utilized PET imaging and ex vivo radio-TLC to provide evidence of the existence and accumulation of microplastics in tissue. Real-time monitoring and tracing of orally administered microplastics are crucial for understanding their toxicity.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Environmental Sciences

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids

Wei Cheng et al.

Summary: This study investigated the adverse biological effects of microplastic particles on human liver using a novel in vitro 3D model, revealing potential hepatotoxicity and disruption of lipid metabolism. The findings provide insights into the risks associated with microplastics on human health.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis

Kai Yin et al.

Summary: This study found that exposure to microplastics caused liver metabolic disorders and increased synthesis of glutamine and glutamate in chickens. Microplastics also reduced the expression of tight junction proteins in the blood-brain barrier and triggered autophagy and apoptosis through the inhibition of signaling pathways, leading to neurological dysfunction.

ENVIRONMENTAL POLLUTION (2022)

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Article Environmental Sciences

Differentiation in the expression of toxic effects of polyethylene-microplastics on two freshwater fish species: Size matters

Dimitra C. Bobori et al.

Summary: The accumulation of microplastics has impacts on aquatic organisms and human health, which require further research. This study found that the response of fish to microplastics is dependent on the particle size, with smaller ones having a greater effect. Moreover, different fish species exhibit varying sensitivity to microplastics.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Polystyrene microplastics increase Pb bioaccumulation and health damage in the Chinese mitten crab Eriocheir sinensis

Zhigang Yang et al.

Summary: The combination of microplastics and lead exposure had a more severe impact on the bioaccumulation of lead, oxidative stress, lipid metabolism, and liver injury in Chinese mitten crabs. This study provides insights into the response of economic crustaceans to the combined stress of lead and microplastics.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Differential cascading cellular and subcellular toxicity induced by two sizes of nanoplastics

Meng Yang et al.

Summary: This study investigated the interaction and toxicity of amine-modified polystyrene nanoparticles (NPs) of two different sizes with zebrafish fibroblast cells. The results showed contrasting cytotoxicity and differential internalization patterns between the two-sized NPs. Deposition of the smaller NPs in the cytosol led to mitochondrial damage and irreversible cell death, while deposition of the larger NPs mainly induced lysosome damage, autophagy activation, and apoptosis. The findings highlight the complex relationship among lysosome damage, autophagy activation, and cell death caused by NPs of different sizes.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Endoplasmic reticulum stress-controlled autophagic pathway promotes polystyrene microplastics-induced myocardial dysplasia in birds

Yue Zhang et al.

Summary: In complex ecosystems, birds serve as good bioindicators for monitoring environmental contaminants due to their long lifespan and high trophic positions. However, the effects of microplastics (MPs) on myocardial development in birds remain unknown. This study established an in vivo model of chicks exposed to polystyrene microplastics (PS-MPs) and an in vitro model using chicken embryos to explore the molecular mechanisms underlying the impact of PS-MPs on bird myocardial development. The results showed that PS-MPs induced myocardial dysplasia in birds through the ER stress-mediated autophagic pathway. This research provides valuable data for protecting birds from the health risks of MPs pollution and offers insights into addressing the issue of MPs pollution in complex ecosystems.

ENVIRONMENTAL POLLUTION (2022)

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Article Engineering, Environmental

Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells

Siyi Lin et al.

Summary: Plastic debris in the global biosphere is a growing concern, with the toxicity of nanoplastic (NPs) in humans not yet fully understood. This study investigates the impact of 80 nm NPs on mitochondrial functions and metabolic pathways in human liver and lung cells. The results show that NPs can enter the cells and cause mitochondrial damage, leading to altered mitochondrial functions and metabolic toxicity. Liver cells are more vulnerable to NP exposure compared to lung cells. This study provides insights into the potential adverse effects of NP-induced mitochondrial dysfunction on human health.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

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Article Engineering, Environmental

Polystyrene micro(nano)plastics damage the organelles of RBL-2H3 cells and promote MOAP-1 to induce apoptosis

Ling Liu et al.

Summary: This study demonstrates that polystyrene particles induce cell apoptosis through oxidative stress, organelle damage, and the regulation of apoptosis-related genes. The upregulation of MOAP-1 is found to promote cell apoptosis through the mitochondrial pathway. The size of polystyrene particles is associated with the severity of mitochondrial damage and apoptosis.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Engineering, Environmental

Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications

Pengfei Wu et al.

Summary: This article provides an overview of the presence and potential health impacts of microplastics in the biosphere, with a focus on inhalation and ingestion as the major exposure pathways. It discusses the absorption, distribution, metabolic toxicity, and excretion of microplastics in the human body, as well as the potential risks associated with them.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Environmental Sciences

Human footprints at hadal depths: interlayer and intralayer comparison of sediment cores from the Kuril Kamchatka trench

Serena M. Abel et al.

Summary: This study conducted analysis of microplastic presence in sediment samples collected from depths of 5740 to 9450 meters in the Kuril Kamchatka trench in the Northwest Pacific Ocean. The results showed a heterogeneous distribution of microplastics, with varying concentrations and polymer types among different sampling stations, reflecting the dynamics of the environment and the forces affecting deposition processes in the trench.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Evaluation of potential toxicity of polyethylene microplastics on human derived cell lines

Ravi Gautam et al.

Summary: Polyethylene microplastics (PE-MPs) have different effects on human cells, depending on the size of the microplastics, cell type, and tissue. PE-MPs can induce intracellular oxidative stress and inflammatory response, but the effects vary among different cell lines.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Human footprints at hadal depths: interlayer and intralayer comparison of sediment cores from the Kuril Kamchatka trench

Serena M. Abel

Summary: The study found that microplastics are deposited on the sea floor, with heterogeneous distribution and varying concentrations and polymer types among different sampling stations in the Kuril Kamchatka trench.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Exposure to polystyrene microplastics induced gene modulated biological responses in zebrafish (Danio rerio)

Sathisaran Umamaheswari et al.

Summary: The study shows that polystyrene microplastics induce various toxic effects in zebrafish, including disrupting the antioxidant defense system, causing histopathological lesions, and altering gene expression patterns.

CHEMOSPHERE (2021)

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Article Engineering, Environmental

Different effects of nano- and microplastics on oxidative status and gut microbiota in the marine medaka Oryzias melastigma

Hye-Min Kang et al.

Summary: The study demonstrates that nanoplastics and microplastics have different pathways of impact on marine medaka, with nanoplastics inducing oxidative stress and microplastics causing intestinal damage and dysbiosis of gut microbiota.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Environmental Sciences

Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis

Haibin Zheng et al.

Summary: Exposure to polystyrene microplastics induced inflammatory effects and exacerbated acute colitis and lipid disorders in mice, suggesting that populations with chronic diseases might be more sensitive to environmental contamination.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Fisheries

Co-administration of zinc for treating and preventing arsenism in common carp Cyprinus carpio: An alternative to avoid physiological and cellular damages

Yu Wang et al.

Summary: Arsenic contamination in water bodies has adverse effects on aquatic organisms, while zinc plays a crucial role in cellular balance and biological functions. The interaction between arsenic and zinc in common carp has been less studied. Arsenic alters intestinal morphology and tight junction proteins, leading to physiological and cellular abnormalities, including oxidative stress, inflammation, detoxification, and immune suppression. Zinc supplementation can mitigate these damages by activating the antioxidant system, serving as an effective treatment and prevention for arsenic poisoning.

AQUACULTURE (2021)

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Article Environmental Sciences

Plasticenta: First evidence of microplastics in human placenta

Antonio Ragusa et al.

Summary: The study revealed the presence of microplastic fragments in human placentas, with different shapes and possible origins from man-made coatings, paints, adhesives, etc.

ENVIRONMENT INTERNATIONAL (2021)

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Article Environmental Sciences

Polystyrene nanoparticles trigger the activation of p38 MAPK and apoptosis via inducing oxidative stress in zebrafish and macrophage cells

Qinglian Hu et al.

Summary: The study revealed that PS NPs induced oxidative damage and inflammatory response in zebrafish larvae and macrophage cells, activating the p38 MAPK signal pathway and leading to cell apoptosis.

ENVIRONMENTAL POLLUTION (2021)

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Article Environmental Sciences

Effects of polystyrene microparticles on inflammation, antioxidant enzyme activities, and related gene expression in Nile tilapia (Oreochromis niloticus)

Ehsan Ahmadifar et al.

Summary: The study aimed to evaluate the adverse impacts of polystyrene microparticles (PS-MPs) on inflammation, immune, and antioxidative responses in Nile tilapia. Results showed that exposure to PS-MPs led to significant changes in antioxidative, inflammatory, and detoxification-related genes in the fish, indicating potential detrimental effects on their health.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Review Toxicology

Distribution and translocation of micro- and nanoplastics in fish

Cuizhu Ma et al.

Summary: The study summarizes the distribution of microplastics and nanoplastics in fish, discusses their translocation ability and pathways into cells. Understanding the presence and translocation mechanisms of these plastic particles in aquatic organisms is crucial for assessing pollution impacts and environmental protection.

CRITICAL REVIEWS IN TOXICOLOGY (2021)

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Article Engineering, Environmental

Microplastic ingestion induces behavioral disorders in mice: A preliminary study on the trophic transfer effects via tadpoles and fish

Amanda Pereira da Costa Araujo et al.

Summary: This study confirmed that polyethylene microplastics can accumulate in animals, affect their behavior, and this impact can be passed on to higher trophic levels in the food chain, negatively impacting the survival of animals.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Environmental Sciences

Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells

Liangtao Zhao et al.

Summary: Oral ingestion of microplastics increases liver weight, alters the immune cell populations and inflammatory cytokine expression, especially affecting the infiltration of natural killer cells and macrophages. These effects are regulated via the NF-κB pathway.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Engineering, Environmental

Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea)

Wencong Lai et al.

Summary: The study revealed that PS NPs adversely affected the survival and growth of carnivorous marine fish, inducing excessive liver lipid accumulation and altering the fatty acid composition and texture of fish muscle.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Marine & Freshwater Biology

Experimental evidence of physiological and behavioral effects of microplastic ingestion in Spurns aurata

Beatriz Rios-Fuster et al.

Summary: Global research has revealed the impact of microplastics on marine organisms. This study found that weathered microplastics induced a stronger physiological response in juvenile Sparus aurata compared to virgin microplastics, with the specific physiological effects varying depending on the tissue analyzed.

AQUATIC TOXICOLOGY (2021)

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Article Nanoscience & Nanotechnology

In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice

Yun Ju Choi et al.

Summary: The study found that oral administration of nanoplastics (NP) for 2 weeks resulted in high accumulation in the liver, kidneys, and intestine of ICR mice, inducing severe inflammatory and oxidative stress responses. Both NP and coagulation-based purified NP had an impact on the biodistribution, toxicity, and inflammatory response in mice.

NANOTOXICOLOGY (2021)

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Article Environmental Sciences

Microplastic accumulation via trophic transfer: Can a predatory crab counter the adverse effects of microplastics by body defence?

Ting Wang et al.

Summary: The study found that both water filtration and food consumption contribute to the accumulation of microplastics in the predatory marine crab. However, biomagnification of microplastics through consumption of contaminated mussels did not occur. The crabs upregulated detoxification and antioxidant defense mechanisms in response to the accumulation of microplastics, but these mechanisms collapsed when the concentration of microplastics exceeded a certain threshold.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

Yung-Li Wang et al.

Summary: The study aimed to investigate the effects of PS-MPs on kidney cells in vitro and in vivo. The results showed that PS-MPs caused mitochondrial dysfunction, ER stress, inflammation, and autophagy in kidney cells, and accumulated in both cells and mouse kidneys.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

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Article Engineering, Environmental

Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid*

Lixin Wang et al.

Summary: Microplastics pollution is a global environmental issue that has received widespread attention, but limited knowledge exists on the detrimental effects of microplastics on human health. This study found that transformed polystyrene microplastics exhibited enhanced cytotoxicity in hepatocytes, with effects including morphological alteration, membrane damage, and increased cell apoptosis through oxidative stress. The exacerbated cytotoxicity was attributed to changes in degradation, surface charge, and surface chemistry of the microplastics after transformation.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Environmental Sciences

Toxicity and Functional Tissue Responses of Two Freshwater Fish after Exposure to Polystyrene Microplastics

Martha Kaloyianni et al.

Summary: The ingestion of microplastics has been shown to impact aquatic organisms, with this study focusing on the effects of polystyrene microplastics on the liver and gills of zebrafish and perch. Biomarkers of oxidative damage increased in exposed fish compared to controls, along with activation of apoptosis and autophagy processes. Different responses were observed in gills and liver, with DNA damage being more significant in the liver.

TOXICS (2021)

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Article Environmental Sciences

Long-term exposure to virgin and seawater exposed microplastic enriched-diet causes liver oxidative stress and inflammation in gilthead seabream Spans aurata, Linnaeus 1758

X. Capo et al.

Summary: The study evaluated the physiological response of gilthead seabream fed with LDPE microplastics, observing an increase in antioxidant enzyme activities, particularly in the seawater exposed group. Despite a slight recovery after 30 days of depuration, the elevated antioxidant defenses were not sufficient to prevent oxidative damage in the liver.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Size-dependent effects of microplastic on uptake, immune system, related gene expression and histopathology of goldfish (Carassius auratus)

Safoura Abarghouei et al.

Summary: With the increase in industrialization, pollution of aquatic ecosystems with plastic derivatives has become a serious concern, affecting the physiological functions of goldfish. Exposure to different concentrations and sizes of polystyrene revealed significant toxic effects on goldfish, inducing histological lesions and oxidative stress responses.

CHEMOSPHERE (2021)

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Article Environmental Sciences

Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio)

Thales Quintao Chagas et al.

Summary: This study found that exposing adult zebrafish to polylactic acid biomicroplastics can lead to accumulation in their bodies and behavioral changes, without causing locomotor damage or anxiety-like behavior. The accumulation may be related to redox imbalance and affects the animals' pigmentation pattern.

CHEMOSPHERE (2021)

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Article Environmental Sciences

Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma)

Xu Zhang et al.

Summary: This study found that different size polystyrene microplastics have effects on lipid metabolism and hepatic toxicity in marine medaka fish, with 200μm microplastics leading to lipid metabolism disorders and liver injury.

ENVIRONMENT INTERNATIONAL (2021)

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Article Engineering, Environmental

Adverse effects polystyrene microplastics exert on zebrafish heart-Molecular to individual level

Anastasia Dimitriadi et al.

Summary: The study found that exposure to polystyrene microplastics (PS-MPs) led to decreased heart function and swimming competence in zebrafish, along with increased oxidative stress and metabolic adjustments, with DNA damage being the most vulnerable indicator to the effects.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Environmental Sciences

Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers

Antonia Solomando et al.

Summary: Exposure to LDPE-MPs had significant impacts on oxidative stress and inflammation biomarkers in the liver and plasma of Sparus aurata, while no significant changes were observed in erythrocytes. During the depuration period, most of these biomarkers showed a trend of recovery and reached levels similar to those of the control group. This indicates a certain degree of reversibility in the effects of LDPE-MPs on S. aurata.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway

Lingai Pan et al.

Summary: The study shows that PS microplastics can induce ER stress in the liver, leading to apoptosis and oxidative stress in hepatocytes.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Polystyrene microplastics induce metabolic disturbances in marine medaka (Oryzias melastigmas) liver

Guozhu Ye et al.

Summary: The study found that exposure to polystyrene microplastics significantly altered the metabolism of marine medaka livers, leading to changes in various metabolic pathways and levels of specific metabolites. The effects of different sizes of microplastics (10-mu m and 200-mu m) on hepatic metabolism were observed, with differences in the impact on carbohydrate, amino acid, and lipid metabolism. Overall, the results provide new insights into the ecotoxicology of microplastics in aquatic organisms.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Polystyrene Microplastics Exposure: An Insight into Multiple Organ Histological Alterations, Oxidative Stress and Neurotoxicity in Javanese Medaka Fish (Oryzias javanicus Bleeker, 1854)

Sunusi Usman et al.

Summary: This study revealed the effects of microplastics on multiple organs of the Javanese medaka fish, causing inflammation, tissue damage, oxidative stress, increased permeability, and neurotoxicity in the intestine, liver, kidney, and brain. Further exploration and identification of biomarkers for biomonitoring high-risk populations in the future are needed.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Cell Biology

ATF4 links ER stress with reticulophagy in glioblastoma cells

Svenja Zielke et al.

Summary: Selective degradation of the endoplasmic reticulum (ER) through reticulophagy is involved in cellular energy restoration and ER homeostasis. The compound loperamide triggers ATF4 upregulation and ER stress, leading to autophagy and autophagic cell death in glioblastoma cells. This process is mediated by the reticulophagy receptors RETREG1 and TEX264.

AUTOPHAGY (2021)

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Article Biochemistry & Molecular Biology

Hepatocellular HO-1 mediated iNOS-induced hepatoprotection against liver ischemia reperfusion injury

Yingli Qiao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Environmental Sciences

Microplastics in house dust from 12 countries and associated human exposure

Junjie Zhang et al.

ENVIRONMENT INTERNATIONAL (2020)

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Article Environmental Sciences

Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics

Mohamed Hamed et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Sreeja Sarasamma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Engineering, Environmental

Impacts of nanoplastics on bivalve: Fluorescence tracing of organ accumulation, oxidative stress and damage

Zhenling Li et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Engineering, Environmental

Hepatotoxicity of pristine polyethylene microplastics in neotropical physalaemus cuvieri tadpoles (Fitzinger, 1826)

Amanda Pereira da Costa Araujo et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Engineering, Environmental

Magnetite nanoparticles effects on adverse responses of aquatic and terrestrial animal models

Martha Kaloyianni et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Environmental Sciences

Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish

Yao Zhao et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Review Environmental Sciences

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Photodegradation Elevated the Toxicity of Polystyrene Microplastics to Grouper (Epinephelus moara) through Disrupting Hepatic Lipid Homeostasis

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Dietary exposure to polyvinyl chloride microparticles induced oxidative stress and hepatic damage in Clarias gariepinus (Burchell, 1822)

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Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae

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Effective uptake of submicrometre plastics by crop plants via a crack-entry mode

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NATURE SUSTAINABILITY (2020)

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The interactions between microplastic polyvinyl chloride and marine diatoms: Physiological, morphological, and growth effects

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Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?

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Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects

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Review Engineering, Environmental

Are we underestimating the sources of microplastic pollution in terrestrial environment?

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Size-dependent cellular internalization and effects of polystyrene microplastics in microalgae P. helgolandica var. tsingtaoensis and S. quadricauda

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Microplastics aggravate the adverse effects of BDE-47 on physiological and defense performance in mussels

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Polystyrene nanoplastics accumulate in ZFL cell lysosomes and in zebrafish larvae after acute exposure, inducing a synergistic immune responsein vitrowithout affecting larval survivalin vivo

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Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice

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Microplastic in cultured oysters from different coastal areas of China

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Evidence of Microplastic Ingestion by Fish from the Bahia Blanca Estuary in Argentina, South America

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Freshwater and airborne textile fibre populations are dominated by 'natural', not microplastic, fibres

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Microplastics in freshwaters and drinking water: Critical review and assessment of data quality

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Human Consumption of Microplastics

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Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring

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Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish

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Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)

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Small Microplastics As a Main Contributor to Plastic Mass Balance in the North Atlantic Subtropical Gyre

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Dietary administration of PVC and PE microplastics produces histological damage, oxidative stress and immunoregulation in European sea bass (Dicentrarchus labrax L.)

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Impacts of polystyrene microplastics on the behavior and metabolism in a marine demersal teleost, black rockfish (Sebastes schlegelii)

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Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish

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Oxidative stress and histological changes in Corbicula fluminea exposed to nano-Al13 and monomeric Al coagulants

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Microplastics in different tissues of fish and prawn from the Musa Estuary, Persian Gulf

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Airborne microplastics: Consequences to human health?

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Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis niloticus)

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Microplastics in Swiss Floodplain Soils

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Microplastics and Nanoplastics in Aquatic Environments: Aggregation, Deposition, and Enhanced Contaminant Transport

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Microplastic in the gastrointestinal tract of fishes along the Saudi Arabian Red Sea coast

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Virgin microplastics are not causing imminent harm to fish after dietary exposure

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First evidence of microplastic ingestion by fishes from the Amazon River estuary

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Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene

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Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

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Single and combined effects of microplastics and cadmium on the cadmium accumulation, antioxidant defence and innate immunity of the discus fish (Symphysodon aequifasciatus)

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Polystyrene microplastics alter the behavior, energy reserve and nutritional composition of marine jacopever (Sebastes schlegelii)

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Ecotoxicological effects of polystyrene microbeads in a battery of marine organisms belonging to different trophic levels

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Microplastics in freshwater and terrestrial environments: Evaluating the current understanding to identify the knowledge gaps and future research priorities

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Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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Microplastic pollution is widely detected in US municipal wastewater treatment plant effluent

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Long-term microplastic retention causes reduced body condition in the langoustine, Nephrops norvegicus

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Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver

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Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells

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Microplastic Pollution in Table Salts from China

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The Impact of Polystyrene Microplastics on Feeding, Function and Fecundity in the Marine Copepod Calanus helgolandicus

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Energy independent uptake and release of polystyrene nanoparticles in primary mammalian cell cultures

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Microplastics in Arctic polar waters: the first reported values of particles in surface and sub-surface samples

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Microplastics in bivalves cultured for human consumption

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Microplastic ingestion decreases energy reserves in marine worms

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Effects of nanopolystyrene on the feeding behavior of the blue mussel (Mytilus edulis L.)

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Refinement and Reduction of Acute Oral Toxicity Testing: A Critical Review of the Use of Cytotoxicity Data

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Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

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The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

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Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.)

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Uptake Mechanism of Oppositely Charged Fluorescent Nanoparticles in HeLa Cells

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Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

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The role of TNFα in ulcerative colitis

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Antioxidant defenses in fish:: Biotic and abiotic factors

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Biodiversity - Invasions by marine life on plastic debris

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Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines

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