期刊
JOURNAL OF MICROENCAPSULATION
卷 33, 期 2, 页码 183-190出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2016.1144816
关键词
formulation; intestinal absorption; digestive stability; Green tea catechins; gamma-CD encapsulation; absorption; HPMCP enteric coating
资金
- National Research Foundation of Korea (NRF) grant - Korea government (MEST) [2014R1A2A2A01007 627]
The hypothesis was that green tea catechins (GTCs) formulated with vitamin C and xylitol followed by enteric coating with hydroxypropyl methyl cellulose phthalate (HPMCP) or encapsulated into gamma-cyclodextrin (gamma-CD) could enhance intestinal absorption of GTCs. Surface morphology and size obtained by SEM were different. Digestive stability of GTCs encapsulated into gamma-CD or coated with HPMCP was enhanced up to 65.56% or 57.63%, respectively. When GTCs were formulated, the digestive stability was greater than the one not formulated. Formulated GTCs followed by encapsulation into gamma-CD significantly increased intestinal transport. Absorption of GTCs was 2.8%, 9.64%, 11.97%, 8.41% and 14.36% for only GTCs, GTCs encapsulated into gamma-CD, formulated GTCs encapsulated into gamma-CD, GTCs coated with HPMCP and formulated GTCs coated with HPMCP, respectively. This study suggests that GTCs, formulated with vitamin C and xylitol followed by gamma-CD encapsulation or HPMCP enteric coating, provide combinational effect to increase bioavailability of GTCs.
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