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Article
Oncology
Rebecca L. Siegel et al.
Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Editorial Material
Gastroenterology & Hepatology
Maria Michela Chiarello et al.
Summary: Early gastric cancer (EGC) is a tumor that only invades the mucosa or submucosa of the stomach, regardless of the lymph node status. EGC is more common in Japan and South Korea compared to Western countries. The Vienna histopathologic classification and the Paris endoscopic classification are the main classification systems for EGC. A careful endoscopic assessment is crucial for determining the best treatment approach, with the option of endoscopic resection or surgical resection and lymphadenectomy depending on the type of EGC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Christian E. H. Schmelzer et al.
Summary: Elastic fibers are essential extracellular components in higher vertebrates that provide elasticity and resilience to various tissues and organs. The formation and maturation of elastic fibers occur in a complex process known as elastogenesis, which involves interactions between different proteins and molecules. Despite their durability, elastic fibers can accumulate damages during aging, leading to potential functional impairments and impacting mortality and morbidity.
Review
Cell Biology
Hiroyuki Suzuki et al.
Summary: Podoplanin plays a critical role in tumor development and normal development of various organs. It is overexpressed in tumors and influences platelet aggregation and signal transductions, thereby contributing to the malignant progression of tumors. Additionally, in the tumor microenvironment, Podoplanin expression is upregulated in the tumor stroma and immune cells, implicating its involvement in tumor development and immune evasion.
Review
Biochemistry & Molecular Biology
Foteini Machla et al.
Summary: This systematic review evaluates the application of potential therapeutic signaling molecules on dentin-pulp complex and pulp tissue regeneration in animal studies. The results highlight the important role of signaling molecules in dentin/pulp regeneration and the need for further research to determine more efficient combinations.
Review
Oncology
Christo Kole et al.
Summary: Neuroendocrine neoplasms encompass NETs and NECs, with increasing incidence over the past 30 years. Despite surgery being the optimal treatment modality, GEP-NETs patients are typically diagnosed at an advanced stage with low 5-year survival rates. Immunotherapy is a promising new treatment approach with demonstrated efficacy against various cancers.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Genetics & Heredity
Rasa Elmentaite et al.
Summary: The development of single-cell and spatial transcriptomics methods has enabled the conception of the Human Cell Atlas initiative, aiming to generate an integrated map of all cells in the human body. By studying human tissues using single-cell gene expression data, we are gaining insights into the commonalities and tissue-specific features of major and supportive cell types within human organs.
NATURE REVIEWS GENETICS
(2022)
Article
Medicine, General & Internal
Arkadiusz Lepucki et al.
Summary: The extracellular matrix is a dynamic molecular network composed of various molecules that play a critical role in regulating cell-cell and cell-matrix interactions, influencing cell growth, migration, and differentiation, as well as serving as a reservoir for cytokines and growth factors. The breakdown of normal ECM and its replacement with tumor ECM is a key driver for tumorigenesis and metastasis, affecting the composition of the tumor microenvironment and promoting malignant progression. Abnormal ECM also affects stromal cells, tumor-associated angiogenesis, inflammation, and the immune response. Understanding the role of ECM in breast cancer can help identify disease markers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Md Zahirul Islam Khan et al.
Summary: Gastrointestinal cancers (GICs) are the most diagnosed cancers and the leading cause of cancer-related death globally. Deficiency of effective early diagnostic biomarkers contributes to poor prognosis and treatment outcomes. Proteomics study and its functional analysis hold promise in improving early diagnosis and management of GICs. Challenges remain in validating proteomics-based biomarkers for translation into clinical practice.
Article
Oncology
Tianyi Fang et al.
Summary: This study constructed predictive models for mortality risk in patients with early-stage gastric cancer, using a combination of serum immune biomarkers and clinicopathological features for individual survival prediction.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Julie S. Di Martino et al.
Summary: Cancer cells disseminate and seed in distant organs, remaining dormant before forming detectable metastases. Research shows that dormant cancer cells assemble an ECM niche enriched with type III collagen, which is essential for sustaining tumor dormancy. Disruption of tumor-derived type III collagen can restore tumor cell proliferation and lead to dormancy-to-reactivation transition.
Review
Surgery
Jun Kinoshita et al.
Summary: With advances in gastric cancer chemotherapy, multimodal treatment including perioperative chemotherapy plus conversion surgery has become a new strategy for treating stage IV gastric cancer patients. Conversion surgery aims to achieve R0 resection after a good response to induction chemotherapy for initially unresectable tumors.
Article
Oncology
Xin Yin et al.
Summary: This study investigated the prognostic significance of inflammatory indexes for patients with different Lauren classifications of GC. SII, pTNM stage, and postoperative chemotherapy were independent risk factors for prognosis in intestinal type GC, while PLR and pTNM stage were independent risk factors for diffuse/mixed type GC. Nomogram models showed good predictive accuracy for 5-year prognosis in both groups of GC patients.
Review
Cell Biology
Andrea Heinz
Summary: This review provides an overview of the role and aging process of elastic fibers in the human lifespan, discussing various factors causing damage to elastic fibers and genetic or acquired pathologies related to the structure and function of elastic fibers and microfibrils, predominantly in the cardiorespiratory system and skin.
AGEING RESEARCH REVIEWS
(2021)
Review
Cell Biology
Zaira Boussadia et al.
Summary: Despite advances in understanding melanoma progression mechanisms, there is still a need for better defining the intercellular molecular steps involved. The acidic and hypoxic microenvironments force melanoma cells to adapt and evolve into a malignant phenotype. Research on the role of melanoma-derived exosomes in acidic and hypoxic conditions is needed.
Review
Cell Biology
Masahide Takahashi et al.
Summary: Recent studies have shown that Cancer-associated fibroblasts (CAFs) have complex functions, including two distinct types: cancer-promoting CAFs and cancer-restraining CAFs. A new cell surface marker, Meflin/Islr, has been identified as a potential marker for rCAFs and mesenchymal stroma/stem cells, showing promise in suppressing cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Thomas R. Cox
Summary: Alterations in the extracellular matrix play a crucial role in the development and progression of solid tumours, and our understanding of matrix biology is expanding. New approaches targeting the matrix in cancer are being developed.
NATURE REVIEWS CANCER
(2021)
Article
Immunology
Tianyi Fang et al.
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Lisandra E. de Castro Bras et al.
Review
Biochemistry & Molecular Biology
Andrea Heinz
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Oncology
Sung Eun Oh et al.
Review
Oncology
Rachel E. Sexton et al.
CANCER AND METASTASIS REVIEWS
(2020)
Review
Oncology
Chencheng Han et al.
BIOMARKER RESEARCH
(2020)
Review
Oncology
Mei Qi Kwa et al.
CLINICAL & EXPERIMENTAL METASTASIS
(2019)
Article
Biochemistry & Molecular Biology
Matteo Ligorio et al.
Review
Pharmacology & Pharmacy
Achilleas D. Theocharis et al.
ADVANCED DRUG DELIVERY REVIEWS
(2016)
Review
Oncology
Raghu Kalluri
NATURE REVIEWS CANCER
(2016)
Review
Cardiac & Cardiovascular Systems
Federico Romaniello et al.
CARDIOVASCULAR PATHOLOGY
(2014)
Article
Dermatology
Romain Debret et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2006)
Review
Oncology
R Kalluri et al.
NATURE REVIEWS CANCER
(2006)
Review
Cell Biology
A Robinet et al.
JOURNAL OF CELL SCIENCE
(2005)
Article
Oncology
K Lapis et al.
SEMINARS IN CANCER BIOLOGY
(2002)
Article
Surgery
Y Kakeji et al.
Article
Biochemistry & Molecular Biology
B Brassart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2001)
