期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.956086
关键词
dyslipidemia; type 2 diabetes mellitus; coronary collateral circulation; coronary artery disease; lipid-lowering therapy
资金
- National Natural Science Foundation of China [81870179, 81870357, 81970362, 81970293, 82170417, 82170423]
- China Postdoctoral Science Foundation [2018M640408]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20181801]
- Technology Transfer Project of Shanghai Jiao Tong University School of Medicine [ZT202103]
- Medicoengineering Research Project of Shanghai Jiao Tong University [YG2021ZD04]
- Shanghai Clinical Research Center for Interventional Medicine [19MC1910300]
Coronary collateralization is impaired in patients with type 2 diabetes and occlusive coronary artery disease, leading to worse prognosis. Dyslipidemia and glycoxidative modification of lipoprotein particles contribute to endothelial dysfunction and impaired collateral vessel growth. The effect of lipid-lowering treatments on collateral formation is also discussed in this review.
Coronary collateralization is substantially impaired in patients with type 2 diabetes and occlusive coronary artery disease, which leads to aggravated myocardial ischemia and a more dismal prognosis. In a diabetic setting, altered serum lipid profiles and profound glycoxidative modification of lipoprotein particles induce endothelial dysfunction, blunt endothelial progenitor cell response, and severely hamper growth and maturation of collateral vessels. The impact of dyslipidemia and lipid-lowering treatments on coronary collateral formation has become a topic of heightened interest. In this review, we summarized the association of triglyceride-based integrative indexes, hypercholesterolemia, increased Lp(a) with its glycoxidative modification, as well as quantity and quality abnormalities of high-density lipoprotein with impaired collateral formation. We also analyzed the influence of innovative lipid-modifying strategies on coronary collateral development. Therefore, clinical management of diabetic dyslipidemia should take into account of its effect on coronary collateralization in patients with occlusive coronary artery disease.
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