期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.968014
关键词
atrial fibrillation; endocannabinoid system; cannabinoid receptor 2; nicotinamide adenine dinucleotide phosphate oxidase; Ca2+; calmodulin-dependent protein kinase II; oxidative stress
资金
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province
- Young Talent Fund of the Military Science and Technology Project
- [81970310]
- [82070239]
- [82170328]
- [2020-MS-036]
- [18-JCJQ-QT-018]
The activation of CB2R has a protective effect against atrial fibrillation (AF) by preventing oxidative stress. CB2R can serve as a potential therapeutic target for treating AF.
BackgroundAtrial fibrillation (AF) is the most frequent arrythmia managed in clinical practice. Several mechanisms have been proposed to contribute to the occurrence and persistence of AF, in which oxidative stress plays a non-negligible role. The endocannabinoid system (ECS) is involved in a variety physiological and pathological processes. Cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R) are expressed in the heart, and studies have shown that activating CB2R has a protective effect on the myocardium. However, the role of CB2R in AF is unknown. Materials and methodsAngiotensin II (Ang II)-infused mice were treated with the CB2R agonist AM1241 intraperitoneally for 21 days. Atrial structural remodeling, AF inducibility, electrical transmission, oxidative stress and fibrosis were measured in mice. ResultsThe susceptibility to AF and the level of oxidative stress were increased significantly in Ang II-infused mice. In addition, nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), NOX4, and oxidized Ca2+/calmodulin-dependent protein kinase II (ox-CaMKII) were highly expressed. More importantly, treatment with AM1241 activated CB2R, resulting in a protective effect. ConclusionThe present study demonstrates that pharmacological activation of CB2R exerts a protective effect against AF via a potential NOX/CaMKII mechanism. CB2R is a potential therapeutic target for AF.
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