Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia

Significant cardiorespiratory coordination is required to maintain physiological function in health and disease. Sensory neuronal cross-talk between the heart and the lungs is required for synchronous regulation of normal cardiopulmonary function and is most likely mediated by the convergence of sensory neural pathways present in the autonomic ganglia. Using neurotracer approaches with appropriate negative control experiments in a mouse model, presence of cardiorespiratory neurons in the vagal (nodose) ganglia are demonstrated. Furthermore, we found that convergent neurons represent nearly 50% of all cardiac neurons and approximately 35% of all respiratory neurons. The current findings demonstrate a pre-existing neuronal substrate linking cardiorespiratory neurotransmission in the vagal ganglia, and a potentially important link for cardiopulmonary cross-sensitization, which may play an important role in the observed manifestations of cardiopulmonary diseases.

Automated summary

Significant cardiorespiratory coordination is required for maintaining physiological function, and the sensory neuronal cross-talk between the heart and the lungs is mediated by sensory neural pathways in the autonomic ganglia. The presence of cardiorespiratory neurons in the vagal ganglia suggests a pre-existing neuronal substrate for cardiorespiratory neurotransmission, which may play an important role in cardiopulmonary diseases.