4.7 Article

Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors

Dries De Ruysscher et al.

Summary: LeuRS is a clinically validated target for antimicrobial development, and bi-substrate inhibitors have shown potent inhibitory activity against bacterial LeuRS. The results of the study could serve as a suitable starting point for further antibiotic development.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Biotechnology & Applied Microbiology

Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Michaelyn C. Lux et al.

JOURNAL OF ANTIBIOTICS (2019)

Article Chemistry, Medicinal

Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily

Dries De Ruysscher et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases

Baole Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Aminoacyl-tRNA synthetases: Structure, function, and drug discovery

Vijayakumar Rajendran et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Biochemistry & Molecular Biology

Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase

Morana Dulic et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes

Mutharasappan Nachiappan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Biochemistry & Molecular Biology

Asparagine synthetase: Function, structure, and role in disease

Carrie L. Lomelino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based

Tishan L. Williams et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Allosteric switch regulates protein-protein binding through collective motion

Colin A. Smith et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Nutrition & Dietetics

Acyl-CoA Metabolism and Partitioning

Trisha J. Grevengoed et al.

ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)

Article Biochemistry & Molecular Biology

The physiological target for LeuRS translational quality control is norvaline

Nevena Cvetesic et al.

EMBO JOURNAL (2014)

Article Biochemistry & Molecular Biology

Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t6A), a universal modification of tRNA

Patrick C. Thiaville et al.

RNA BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Structural Diversity and Protein Engineering of the Aminoacyl-tRNA Synthetases

John J. Perona et al.

BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Mechanism of the activation step of the aminoacylation reaction: a significant difference between class I and class II synthetases

Sindrila Dutta Banik et al.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2012)

Article Biochemistry & Molecular Biology

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

Andres Palencia et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemical Research Methods

Data processing and analysis with the autoPROC toolbox

Clemens Vonrhein et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Acyl-CoA synthesis, lipid metabolism and lipotoxicity

Lei O. Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)

Review Biochemistry & Molecular Biology

Acyl-coenzyme A synthetases in metabolic control

Jessica M. Ellis et al.

CURRENT OPINION IN LIPIDOLOGY (2010)

Article Biochemistry & Molecular Biology

Adenylate-forming enzymes

Stefan Schmelz et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)

Article Multidisciplinary Sciences

CP1-dependent partitioning of pretransfer and posttransfer editing in leucyl-tRNA synthetase

Michal T. Boniecki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Article Biochemistry & Molecular Biology

Modulation of substrate specificity within the amino acid editing site of leucyl-tRNA synthetase

Yuxin Zhai et al.

BIOCHEMISTRY (2007)

Review Pharmacology & Pharmacy

Targeting purine and pyrimidine metabolism in human apicomplexan parasites

John E. Hyde

CURRENT DRUG TARGETS (2007)

Article Biochemistry & Molecular Biology

Distinct kinetic mechanisms of the two classes of aminoacyl-tRNA synthetases

Chun-Mei Zhang et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation

M Tukalo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Article Biochemical Research Methods

Protein production by auto-induction in high-density shaking cultures

FW Studier

PROTEIN EXPRESSION AND PURIFICATION (2005)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Groups on the side chain of T252 in Escherichia coli leucyl-tRNA synthetase are important for discrimination of amino acids and cell viability

MG Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

tRNA-dependent active site assembly in a class I aminoacyl-tRNA synthetase

LD Sherlin et al.

STRUCTURE (2003)

Article Biochemistry & Molecular Biology

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

TL Lincecum et al.

MOLECULAR CELL (2003)

Article Biochemistry & Molecular Biology

ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding

S Sekine et al.

EMBO JOURNAL (2003)

Article Multidisciplinary Sciences

Modulation of tRNAAla identity by inorganic pyrophosphatase

AD Wolfson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Peptide-plane flipping in proteins

S Hayward

PROTEIN SCIENCE (2001)

Article Biochemistry & Molecular Biology

CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function

JF Chen et al.

BIOCHEMISTRY (2000)