相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Enantioselective Povarov Reactions: An Update of a Powerful Catalytic Synthetic Methodology
Barbara C. Lemos et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2022)
Enantioselective catalytic Povarov reactions
Jose Clerigue et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2022)
Local Anesthetics via Multicomponent Reactions
Maria Thomaidi et al.
CHEMMEDCHEM (2022)
Ideality in Context: Motivations for Total Synthesis
David S. Peters et al.
ACCOUNTS OF CHEMICAL RESEARCH (2021)
Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020)
Hafiza Amna Younus et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2021)
Still Relevant Today: The Asinger Multicomponent Reaction
Nefeli Griboura et al.
CHEMMEDCHEM (2021)
Ketene 3-Component Staudinger Reaction (K-3CSR) to β-Lactams: A New Entry in the Class of Photoinduced Multicomponent Reactions
Federica Minuto et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)
The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity
Martin Kalnik et al.
MOLECULES (2021)
The 100 facets of the Passerini reaction
Luca Banfi et al.
CHEMICAL SCIENCE (2021)
The Ugi three-component reaction and its variants
Julio Cesar Flores-Reyes et al.
ORGANIC CHEMISTRY FRONTIERS (2021)
Enantioselective three-component Ugi reaction catalyzed by chiral phosphoric acid
Jian Zhang et al.
SCIENCE CHINA-CHEMISTRY (2020)
Synthesis of Biologically Active Molecules through Multicomponent Reactions
Daniel Insuasty et al.
MOLECULES (2020)
Efficient Multikilogram Synthesis of a VLA-4 Antagonist via a Povarov Reaction
Patrick Cerfontaine et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2020)
Continuous-Flow Synthesis of Tramadol from Cyclohexanone
Timothy M. Monos et al.
SYNLETT (2020)
Investigating Ugi/Passerini Multicomponent Reactions for the Site-Selective Conjugation of Native Trastuzumab
Charlotte Sornay et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
The mGluR2/3 agonist pomaglumetad methionil normalizes aberrant dopamine neuron activity via action in the ventral hippocampus
Susan F. Sonnenschein et al.
NEUROPSYCHOPHARMACOLOGY (2020)
Tubulysin Synthesis Featuring Stereoselective Catalysis and Highly Convergent Multicomponent Assembly
Thimmalapura M. Vishwanatha et al.
ORGANIC LETTERS (2020)
Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications
Manar Ahmed Fouad et al.
RSC ADVANCES (2020)
Efficient Synthesis of 2-Amino-1-Arylethanols Through a Lewis Base-Catalyzed SiCl4-Mediated Asymmetric Passerini-Type Reaction
Aurelie Gernet et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)
Domino and one-pot syntheses of biologically active compounds using diphenylprolinol silyl ether
Yujiro Hayashi
PHYSICAL SCIENCES REVIEWS (2020)
Multicomponent Reactions-Based Modified/Functionalized Materials in the Biomedical Platforms
Siamak Javanbakht et al.
ACS APPLIED BIO MATERIALS (2020)
Atorvastatin (Lipitor) by MCR
Tryfon Zarganes-Tzitzikas et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Multicomponent Reactions for the Synthesis of Bioactive Compounds: A Review
Cedric S. Graebin et al.
CURRENT ORGANIC SYNTHESIS (2019)
Reactivity and Synthetic Applications of Multicomponent Petasis Reactions
Peng Wu et al.
CHEMICAL REVIEWS (2019)
The Hantzsch Pyrrole Synthesis: Non-conventional Variations and Applications of a Neglected Classical Reaction
Marco Leonardi et al.
SYNTHESIS-STUTTGART (2019)
Multicomponent Reactions in Ligation and Bioconjugation Chemistry
Leslie Reguera et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to beta-Amino Alcohols
Jordy M. Saya et al.
ORGANIC LETTERS (2018)
Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties
Vladimir V. Kouznetsov et al.
TETRAHEDRON (2018)
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Janeta Popovici-Muller et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Recent advances in the intramolecular Mannich reaction in natural products total synthesis
Yingbo Shi et al.
ORGANIC CHEMISTRY FRONTIERS (2018)
Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review
Ramandeep Kaur et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
The E factor 25 years on: the rise of green chemistry and sustainability
Roger A. Sheldon
GREEN CHEMISTRY (2017)
A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes
Joice Thomas et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2017)
Multicomponent Mannich reactions: General aspects, methodologies and applications
Joao F. Allochio Filho et al.
TETRAHEDRON (2017)
Recent Advances in the Pauson-Khand Reaction
J. David Ricker et al.
TOPICS IN CATALYSIS (2017)
Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold
Laure Konnert et al.
CHEMICAL REVIEWS (2017)
Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R)-Sitagliptin
Han Yong Bae et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction
Yasuharu Shimasaki et al.
CHEMISTRY LETTERS (2016)
Mechanochemical Strecker Reaction: Access to -Aminonitriles and Tetrahydroisoquinolines under Ball-Milling Conditions
Jose G. Hernandez et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
An efficient Passerini tetrazole reaction (PT-3CR)
Ajay L. Chandgude et al.
GREEN CHEMISTRY (2016)
2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry
Gydo van der Heijden et al.
ORGANIC LETTERS (2016)
Time Economical Total Synthesis of (-)-Oseltamivir
Yujiro Hayashi et al.
ORGANIC LETTERS (2016)
Theoretical study of the regio- and stereoselectivity of the intramolecular Povarov reactions yielding 5H-chromeno[2,3-c] acridine derivatives
Meriem Awatif Mahi et al.
RSC ADVANCES (2016)
Three-Component Synthesis of Pyrrole-Related Nitrogen Heterocycles by a Hantzsch-Type Process: Comparison between Conventional and High-Speed Vibration Milling Conditions
Veronica Estevez et al.
ASIAN JOURNAL OF ORGANIC CHEMISTRY (2016)
Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction
Andras Varadi et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Multicomponent Reactions, Union of MCRs and Beyond
Tryfon Zarganes-Tzitzikas et al.
CHEMICAL RECORD (2015)
Synthesis of pretubulysin-derivatives via the TubUgi-approach
Judith Hoffmann et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Development of Scalable Conditions for the Ugi Reaction-Application to the Synthesis of (R)-Lacosamide
Hermut Wehlan et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2015)
A DFT study of the mechanism of Bronsted acid catalysed Povarov reactions
Mar Rios-Gutierrez et al.
TETRAHEDRON (2015)
Total synthesis of atorvastatin via a late-stage, regioselective 1,3-dipolar munchnone cycloaddition
Justin M. Lopchuk et al.
TETRAHEDRON LETTERS (2015)
Insights on the Petasis Borono-Mannich multicomponent reaction mechanism
Roberto Y. Souza et al.
RSC ADVANCES (2015)
Continuous-Flow Synthesis and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities
Chunhui Dai et al.
JOURNAL OF FLOW CHEMISTRY (2015)
An Efficient Synthesis of Pemetrexed Disodium
H. Qi et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2015)
Convenient synthesis of 2,3-disubstituted quinazolin-4(3H)-ones and 2-styryl-3-substituted quinazolin-4(3H)-ones: applications towards the synthesis of drugs
Dinesh Kumar et al.
RSC ADVANCES (2015)
Applications of Mannich Reaction in Total Syntheses of Natural Products
Majid M. Heravi et al.
CURRENT ORGANIC CHEMISTRY (2014)
Asymmetric Synthesis of 3,4-Disubstituted Proline Derivatives: Application in Synthesis of Hepatitis C Virus Protease Inhibitor Telaprevir
Fan Zhang et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2014)
Understanding the mechanism of the Povarov reaction. A DFT study
Luis R. Domingo et al.
RSC ADVANCES (2014)
Facile Ecofriendly Synthesis of Monastrol and Its Structural Isomers via Biginelli Reaction
Manuela Oliverio et al.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2014)
Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions
Veronica Estevez et al.
ORGANIC CHEMISTRY FRONTIERS (2014)
Modern multicomponent reactions for better drug syntheses
Tryfon Zarganes-Tzitzikas et al.
ORGANIC CHEMISTRY FRONTIERS (2014)
Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis
Veronica Estevez et al.
CHEMICAL COMMUNICATIONS (2013)
Robinson's landmark synthesis of tropinone
Jonathan William Medley et al.
CHEMICAL COMMUNICATIONS (2013)
One-Pot Synthesis of (-)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction
Takasuke Mukaiyama et al.
CHEMISTRY-A EUROPEAN JOURNAL (2013)
MCR Synthesis of Praziquantel Derivatives
Haixia Liu et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2012)
Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083
Fa-Guang Zhang et al.
CHEMICAL COMMUNICATIONS (2012)
Chemistry and Biology Of Multicomponent Reactions
Alexander Domling et al.
CHEMICAL REVIEWS (2012)
Chelation therapy in Wilson's disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators
Pascale Delangle et al.
DALTON TRANSACTIONS (2012)
Modified Asymmetric Strecker Reaction of Aldehyde with Secondary Amine: A Protocol for the Synthesis of S-Clopidogrel (An Antiplatelet Agent)
Arghya Sadhukhan et al.
JOURNAL OF ORGANIC CHEMISTRY (2012)
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
Eelco Ruijter et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
The Multiple Multicomponent Approach to Natural Product Mimics: Tubugis, N-Substituted Anticancer Peptides with Picomolar Activity
Orlando Pando et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Enecarbamates as Dienophiles: Highly Diastereo- and Enantioselective Synthesis of Substituted 4-Aminotetrahydroquinolines
Guillaume Dagousset et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
The Gewald multicomponent reaction
Yijun Huang et al.
MOLECULAR DIVERSITY (2011)
Process Development for a Key Synthetic Intermediate of LY2140023, a Clinical Candidate for the Treatment of Schizophrenia
Mario Waser et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2011)
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5
Kai Schiemann et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions
Anass Znabet et al.
CHEMICAL COMMUNICATIONS (2010)
Lewis Acid Activated Aza-Diels-Alder Reaction of N-(3-Pyridyl)aldimines: An Experimental and Computational Study
Francisco Palacios et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2010)
On the industrial applications of MCRs: molecular diversity in drug discovery and generic drug synthesis
Cedric Kalinski et al.
MOLECULAR DIVERSITY (2010)
Chiral Bronsted Acid-Catalyzed Enantioselective Three-Component Povarov Reaction
Hua Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
The discovery of GSK221149A: A potent and selective oxytocin antagonist
John Liddle et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Enantioselective Syntheses of Carbanucleosides from the Pauson-Khand Adduct of Trimethylsilylacetylene and Norbornadiene
Ana Vazquez-Romero et al.
ORGANIC LETTERS (2008)
Multicomponent Reactions as a Powerful Tool for Generic Drug Synthesis
Cedric Kalinski et al.
SYNTHESIS-STUTTGART (2008)
Enol esters:: Versatile substrates for Mannich-Type multicomponent reactions
Nicolas Isambert et al.
ORGANIC LETTERS (2007)
Synthetic improvements in the preparation of clopidogrel
Lixin Wang et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2007)
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite
Rena Nishizawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Recent developments in isocyanide based multicomponent reactions in applied chemistry
A Domling
CHEMICAL REVIEWS (2006)
Regiospecific and stereoselective syntheses of (±)-reserpine and (-)-reserpine
G Stork et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Discovery and preclinical profile of saxagliptin (BMS-477118): A highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
DJ Augeri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Short and novel stereospecific synthesis of trisubstituted 2,5-diketopiperazines
SL Sollis
JOURNAL OF ORGANIC CHEMISTRY (2005)
A Pauson-Khand approach to new carbocyclic nucleoside analogs
A Lanver et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2005)
The direct catalytic asymmetric Mannich reaction
A Córdova
ACCOUNTS OF CHEMICAL RESEARCH (2004)
The first catalytic, asymmetric α-additions of isocyanides.: Lewis-base-catalyzed, enantioselective Passerini-type reactions
SE Denmark et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
The chemistry of isocyanides, their multicomponent reactions and their libraries
I Ugi et al.
MOLECULES (2003)
Development of a general process for the synthesis of highly substituted imidazoles
J Sisko et al.
PURE AND APPLIED CHEMISTRY (2002)
Total synthesis of ecteinascidin 743
A Endo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
分享论文
