Antiviral Treatment Options for Severe Fever with Thrombocytopenia Syndrome Infections

Article Medicine, General & Internal

Plasma Exchange Did Not Reduce Viral Load in a Recovered Case of Severe Fever with Thrombocytopenia Syndrome

Rie Utsunomiya Nishimizu et al.

Summary: This article reports a SETS patient whose SFTSV viral load was measured before and after plasma exchange. The results showed that plasma exchange did not reduce the SFTSV viral load.

INTERNAL MEDICINE (2022)

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Review Microbiology

Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection

Jiawen Sun et al.

Summary: Animal models are crucial for studying the pathogenic processes, developing treatments and prevention strategies for severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS bunyavirus. This review summarizes the current progress in SFTSV animal models, including the susceptibility of various animals to SFTSV, clinical manifestations, histopathological changes, and the use of animal models in studying molecular mechanisms, vaccine candidates, and antiviral drugs. The strengths, limitations, and future directions for SFTSV animal models are also discussed, highlighting the importance of further exploration and optimization of these models.

FRONTIERS IN MICROBIOLOGY (2022)

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Letter Virology

Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus

Jingjing Yang et al.

VIROLOGICA SINICA (2022)

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Article Infectious Diseases

Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus

Motohiko Ogawa et al.

Summary: The o-dihydroxybenzene backbone in caffeic acid and its analogs is crucial for their anti-SFTSV activity. Modifying this backbone with various residues may enhance the antiviral effect against SFTSV.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

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Article Virology

Severe fever with thrombocytopenia syndrome in Hefei: Clinical features, risk factors, and ribavirin therapeutic efficacy

Yin Zhang et al.

Summary: This study described the clinical features, risk factors, outcome factors, and ribavirin therapeutic efficacy for severe fever with thrombocytopenia syndrome (SFTS) patients in Hefei. Clinical features, prognostic factors, and risk factors associated with SFTS in Hefei are similar to those in other areas. Patients treated with ribavirin did not show better survival rates compared to those who were not treated with ribavirin.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Pharmacology & Pharmacy

Acute and severe ribavirin-associated hyperuricemia is and acute kidney injury: An underrecognized adverse effect

Razan Sakran et al.

Summary: A 21-year-old male with a history of B-cell acute lymphoblastic leukemia developed severe hyperuricemia and acute kidney injury after receiving ribavirin for respiratory syncytial virus infection. The patient's uric acid and creatinine levels improved after discontinuation of ribavirin and administration of rasburicase. This case highlights the importance of monitoring for hyperuricemia when using ribavirin in immunocompromised patients.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2021)

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Article Integrative & Complementary Medicine

The preventive effect of Xuebijing injection against cytokine storm for severe patients with COVID-19: A prospective randomized controlled trial

Zhijian Luo et al.

Summary: The study demonstrates that Xuebijing injection can effectively suppress the cytokine storm in severe COVID-19 patients by reducing the secretion of pro-inflammatory cytokines IL-6, IL-8, and TNF-??????, increasing lymphocyte levels, and decreasing CRP levels. However, Xuebijing did not significantly reduce the 28-day mortality rate.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE (2021)

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Article Microbiology

Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome

Angela Park et al.

Summary: This study identified differential inflammatory cytokine levels in SFTS patients, with fatal cases showing expanded B cell populations and plasma cells as the viral reservoir. Altered B cell function was found to be associated with lethality in SFTSV infections.

MBIO (2021)

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Article Nutrition & Dietetics

Caffeic Acid Modulates Processes Associated with Intestinal Inflammation

Danuta Zielinska et al.

Summary: The study showed that caffeic acid can modulate mechanisms related to intestinal inflammation by targeting COX-2, PGE(2) synthesis, and IL-8 biosynthesis. Additionally, it inhibits AGE formation, possibly due to its high chelating activity.

NUTRIENTS (2021)

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Article Infectious Diseases

A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome

Koichiro Suemori et al.

Summary: Favipiravir has shown effectiveness in treating patients with Severe fever with thrombocytopenia syndrome (SFTS), with a lower 28-day mortality rate compared to previous studies. Although adverse events were observed in some patients, the drug was generally well tolerated and showed potential in improving clinical symptoms and reducing viral load in SFTS patients.

PLOS NEGLECTED TROPICAL DISEASES (2021)

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Article Cell Biology

Single-cell landscape of peripheral immune responses to fatal SFTS

Hao Li et al.

Summary: The single-cell landscape of peripheral immune responses in SFTS patients is reprogrammed, with potential targets including intermediate monocytes and IFN-I-inducible plasmablasts. A retrospective clinical study showed no efficiency of IFN-α in treating SFTS, indicating the pivotal role of the IFN-I response in exacerbating hyperinflammation and lethal SFTS.

CELL REPORTS (2021)

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Article Pharmacology & Pharmacy

Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach

Ruhao Yang et al.

Summary: Using network pharmacology, this study predicted the active components and effective targets of LHQW in treating acute lung injury, and validated the protective mechanism of LHQW in ALI through experiments.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Efficacy and Safety of Traditional Chinese Medicine Injections for Heart Failure With Reduced Ejection Fraction: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

Shanshan Lin et al.

Summary: This study compared the efficacy and safety of different Traditional Chinese Medicine Injections (TCMIs) for treating Heart Failure with Reduced Ejection Fraction (HFrEF) through a Bayesian network meta-analysis. Results showed that combining qualified TCMIs with conventional treatment was more effective than using conventional treatment alone, with CT + XML and CT + SM potentially optimal. Safety of TCMIs needs further observation and conclusions require verification through more large-sample, double-blind, multi-center RCTs.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Clinical efficacy and safety evaluation of favipiravir in treating patients with severe fever with thrombocytopenia syndrome

Yang Yuan et al.

Summary: Favipiravir (FPV) treatment significantly reduced the case fatality rate in SFTS patients, but showed heterogeneity in different age groups, onset-to-admission intervals, initial viral loads, and therapy durations. FPV was beneficial for patients aged <= 70 years with specific conditions, but did not benefit those aged >70 years.

EBIOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues

Leentje Persoons et al.

Summary: This study demonstrated that several quinoline analogues, including chloroquine, hydroxychloroquine, amodiaquine, ferroquine, and mefloquine, exhibit broad-spectrum anti-coronavirus activity in vitro, with chloroquine and hydroxychloroquine showing the most potent effects and favorable selectivity index.

ANTIVIRAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Caffeic Acid on Metabolic Syndrome: A Review

Nellysha Namela Muhammad Abdul Kadar et al.

Summary: Metabolic syndrome (MetS) is a combination of risk factors that can lead to serious diseases, and with unhealthy lifestyles and the COVID-19 pandemic, the number of affected individuals is expected to increase. While there are multiple medications available to control these risk factors, there is no single strategy to stop or reduce the impact of MetS on patients, opening the door for the search for more natural control methods.

MOLECULES (2021)

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Article Virology

M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening

Hiroshi Yamada et al.

Summary: The study identified four candidate inhibitors that exhibited strong inhibitory effects on SFTSV minigenome activity with low cell cytotoxicity, showing potential antiviral properties.

VIRUSES-BASEL (2021)

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Review Virology

Clinical Update of Severe Fever with Thrombocytopenia Syndrome

Jun-Won Seo et al.

Summary: SFTS is an acute febrile illness caused by the SFTSV virus, primarily transmitted by tick bites, with a high mortality rate and lack of established treatment strategies. Current treatments for SFTS include antiviral agents and other specific methods.

VIRUSES-BASEL (2021)

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Article Microbiology

Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus

Jennifer Mayor et al.

Summary: Ecological changes, population movements, and increasing urbanization contribute to the spread of hantaviruses, posing a high risk of virus transmission and diseases to humans; Ribavirin is currently the only antiviral medication used to treat HFRS caused by HTNV, but with severe side effects; Favipiravir has shown similar potent antiviral activity on HTNV infection, and when used in combination with low-dose ribavirin, its efficacy is enhanced, suggesting the potential for improved treatment.

MICROORGANISMS (2021)

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Article Biochemistry & Molecular Biology

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

Hao Li et al.

Summary: The study showed that T-705 treatment for SFTS can reduce case fatality rate, especially in patients with low viral loads. The T-705-treated group exhibited faster viral clearance, lower incidence of hemorrhagic signs, and quicker recovery from laboratory abnormalities compared to the controls.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Infectious Diseases

Severe fever with thrombocytopenia syndrome (SFTS) treated with a novel antiviral medication, favipiravir (T-705)

Rui Song et al.

INFECTION (2020)

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Article Biotechnology & Applied Microbiology

ICTV Virus Taxonomy Profile: Peribunyaviridae

Holly R. Hughes et al.

JOURNAL OF GENERAL VIROLOGY (2020)

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Article Microbiology

Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation

Panpan Wang et al.

NATURE MICROBIOLOGY (2020)

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Article Medicine, Research & Experimental

A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo

Xilin Wu et al.

JCI INSIGHT (2020)

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Article Medicine, General & Internal

Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome

Jeong Rae Yoo et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2019)

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Article Microbiology

An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus

Ki Hyun Kim et al.

PLOS PATHOGENS (2019)

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Article Virology

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Shuofeng Yuan et al.

VIRUSES-BASEL (2019)

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Article Cell Biology

Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality

Hao Li et al.

CELL RESEARCH (2019)

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Review Infectious Diseases

Identification of the crucial parameters regarding the efficacy of ribavirin therapy in Crimean-Congo haemorrhagic fever (CCHF) patients: a systematic review and meta-analysis

Zahra Arab-Bafrani et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

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Article Virology

Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus

Sihua Liu et al.

VIROLOGICA SINICA (2019)

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Article Biochemistry & Molecular Biology

The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus

Shuzo Urata et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Infectious Diseases

Caffeic acid, a coffee-related organic acid, inhibits infection by severe fever with thrombocytopenia syndrome virus in vitro

Motohiko Ogawa et al.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2018)

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Article Multidisciplinary Sciences

Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration

Hideki Tani et al.

PLOS ONE (2018)

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Article Cell Biology

Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome

Xiao-Kun Li et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Virology

Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir

Brian B. Gowen et al.

JOURNAL OF VIROLOGY (2017)

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Review Biochemistry & Molecular Biology

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling

Rafaela Bagur et al.

MOLECULAR CELL (2017)

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Article Multidisciplinary Sciences

Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope

Yan Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Integrative & Complementary Medicine

Cost-effectiveness analysis of traditional Chinese medicine for the treatment of upper respiratory tract infections Yuxingcao Qinlan mixture versus LanQin oral liquid-A prospective study

Meng Zheng et al.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE (2017)

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Article Medicine, General & Internal

In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus

Myung Jin Lee et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2017)

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Article Medicine, General & Internal

Effect of Artesunate-Amodiaquine on Mortality Related to Ebola Virus Disease

Etienne Gignoux et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Microbiology

Efficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome Virus

Hideki Tani et al.

MSPHERE (2016)

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Article Pharmacology & Pharmacy

Evaluation of Crimean-Congo hemorrhagic fever virus in vitro inhibition by chloroquine and chlorpromazine, two FDA approved molecules

O. Ferraris et al.

ANTIVIRAL RESEARCH (2015)

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Article Multidisciplinary Sciences

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

Yasuteru Sakurai et al.

SCIENCE (2015)

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Article Virology

Combination effects of ribavirin and interferons on severe fever with thrombocytopenia syndrome virus infection

Masayuki Shimojima et al.

VIROLOGY JOURNAL (2015)

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Review Immunology

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

K. D. Rainsford et al.

INFLAMMOPHARMACOLOGY (2015)

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Article Hematology

Evaluation of Plasma Exchange and Continuous Veno-Venous Hemofiltration for the Treatment of Severe Avian Influenza A (H7N9): A Cohort Study

Xiaoli Liu et al.

THERAPEUTIC APHERESIS AND DIALYSIS (2015)

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Article Pharmacology & Pharmacy

Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity

Siwaporn Boonyasuppayakorn et al.

ANTIVIRAL RESEARCH (2014)

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Article Infectious Diseases

Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome

Won Sup Oh et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2014)

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Article Infectious Diseases

Effects of Ribavirin on Severe Fever with Thrombocytopenia Syndrome Virus In Vitro

Masayuki Shimojima et al.

JAPANESE JOURNAL OF INFECTIOUS DISEASES (2014)

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Article Infectious Diseases

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

Gerrit Gehring et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)

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Article Immunology

The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan

Toru Takahashi et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

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Article Immunology

Severe Fever with Thrombocytopenia Syndrome Virus in Ticks Collected from Humans, South Korea, 2013

Seok-Min Yun et al.

EMERGING INFECTIOUS DISEASES (2014)

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Article Immunology

Case-Fatality Ratio and Effectiveness of Ribavirin Therapy Among Hospitalized Patients in China Who Had Severe Fever With Thrombocytopenia Syndrome

Wei Liu et al.

CLINICAL INFECTIOUS DISEASES (2013)

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Article Cell Biology

siRNA Screen for Genes That Affect Junin Virus Entry Uncovers Voltage-Gated Calcium Channels as a Therapeutic Target

Madakasira Lavanya et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Medicine, General & Internal

A New Phlebovirus Associated with Severe Febrile Illness in Missouri

Laura K. McMullan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Multidisciplinary Sciences

Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

Cong Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Medicine, General & Internal

Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China

Xue-Jie Yu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Review Pharmacology & Pharmacy

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

Yousuke Furuta et al.

ANTIVIRAL RESEARCH (2009)

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Review Cell Biology

Viral calciomics: Interplays between Ca2+ and virus

Yubin Zhou et al.

CELL CALCIUM (2009)

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Article Virology

Cholesterol biosynthesis modulation regulates dengue viral replication

Christopher Rothwell et al.

VIROLOGY (2009)

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Review Ophthalmology

Ocular toxicity of fludarabine: a purine analog

Xiaoyan Ding et al.

EXPERT REVIEW OF OPHTHALMOLOGY (2008)

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Article Gastroenterology & Hepatology

Hematologic side effects of interferon and ribavirin therapy

KV Kowdley

JOURNAL OF CLINICAL GASTROENTEROLOGY (2005)

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Article Hematology

Role of fludarabine as monotherapy in the treatment of chronic lymphocytic leukemia

M Leporrier

HEMATOLOGY JOURNAL (2004)

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Article Microbiology

In vitro and in vivo activities of anti-influenza virus compound T-705

Y Furuta et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)

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Antiviral Treatment Options for Severe Fever with Thrombocytopenia Syndrome Infections

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