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Dendrimers, an Emerging Opportunity in Personalized Medicine?

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Biochemical Research Methods

Dendrimer-Based Nanogels for Cancer Nanomedicine Applications

Shewaye Lakew Mekuria et al.

Summary: Nanogels are nanosized superconstructs composed of amphiphilic or hydrophilic polymer networks, with unique physicochemical properties that make them suitable for various biomedical applications, particularly in cancer nanomedicine. Dendrimer-based NGs can be synthesized via different methods and used for drug delivery, gene delivery, photothermal therapy, combination therapy, and biological imaging-guided chemotherapy in cancer treatment. Future perspectives include designing new dendrimer-based NGs for different cancer nanomedicine applications.

BIOCONJUGATE CHEMISTRY (2022)

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Review Nanoscience & Nanotechnology

Curing inflammatory diseases using phosphorous dendrimers

Anne-Marie Caminade et al.

Summary: Different types of water-soluble phosphorous dendrimers with various biological properties, such as stimulating the immune system and displaying anti-inflammatory effects, have been synthesized. These dendrimers have shown potential in the treatment of chronic or acute inflammatory diseases and hematological cancers in animal models. Safety assessments have demonstrated their hematological safety both in mice and non-human primates.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

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Review Obstetrics & Gynecology

Astodrimer sodium and bacterial vaginosis: a mini review

Werner Mendling et al.

Summary: Bacterial vaginosis (BV) is a common vaginal infection that greatly affects the physical, emotional, sexual, and social lives of women of childbearing age. Astodrimer sodium gel is a novel non-antibiotic treatment for BV that prevents pathogenic bacteria from adhering to the vaginal wall and inhibits the formation of bacterial biofilms. Clinical trials have shown higher cure rates and lower recurrence rates in patients treated with astodrimer sodium compared to placebo.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Article Medicine, General & Internal

The DendrisCHIP® Technology as a New, Rapid and Reliable Molecular Method for the Diagnosis of Osteoarticular Infections

Elodie Bernard et al.

Summary: In this study, a molecular diagnostic technology called DendrisCHIP (R) OA was reported for accurate identification of pathogen bacteria in osteoarticular infections. This technology combines the advantages of PCR and NGS while overcoming their limitations and constraints. Compared to microbial culture and NGS, DendrisCHIP (R) OA is able to detect a wider range of pathogens and provides faster diagnostic results.

DIAGNOSTICS (2022)

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Article Chemistry, Multidisciplinary

Subcutaneous delivery of a dendrimer-BH3 mimetic improves lymphatic uptake and survival in lymphoma

Orlagh M. Feeney et al.

Summary: This study investigates the impact of subcutaneous dosing on lymphatic exposure, pharmacokinetics, and efficacy of AZD0466. The results show that subcutaneous dosing leads to longer half-life, higher lymphatic transport rate, and improved tolerance. Additionally, higher doses of subcutaneous administration result in improved efficacy.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Cell Biology

Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial

Aaron M. Gusdon et al.

Summary: The findings suggest that OP-101 is well tolerated and may have the potential to reduce inflammation and neuronal injury, leading to decreased morbidity and mortality in severe COVID-19 patients.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial

Alex Castellarnau et al.

Summary: This study assessed the safety and absorption of Astodrimer sodium as a nasal spray for antiviral purposes. The results showed that Astodrimer sodium was well tolerated when applied to the nasal mucosa and did not cause systemic absorption. This promising innovation warrants further investigation for reducing infection and spread of respiratory viruses.

SCIENTIFIC REPORTS (2022)

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Article Cell Biology

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

Surein Arulananda et al.

Summary: The study found that the inhibitor AZD4320 targeting BCL-XL can effectively kill malignant pleural mesothelioma tumor cells, with enhanced effects when used in combination with AZD5991. A novel nanoparticle, AZD0466, showed similar effectiveness to standard chemotherapy drug Cisplatin in inhibiting tumor growth in mouse xenograft studies, while reducing thrombocytopenia associated with BCL-XL inhibition.

CELL DEATH DISCOVERY (2021)

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Article Biology

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire M. Patterson et al.

Summary: The study presents the design and development of AZD0466, a drug-dendrimer conjugate, and uses preclinical and mathematical models to determine the optimal release rate of the drug for maximal therapeutic index. The optimized candidate shows improved efficacy and tolerability compared to AZD4320 alone, enabling progression of this promising dual Bcl-2/Bcl-x(L) inhibitor into clinical development.

COMMUNICATIONS BIOLOGY (2021)

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Article Allergy

Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation

Musa Khaitov et al.

Summary: The study identified siR-7 as the most efficient siRNA targeting SARS-CoV-2 RNA-dependent RNA polymerase in inhibiting viral replication in vitro. Modification with LNAs and complexation with the designed peptide dendrimer enhanced the antiviral capacity of siR-7 in vitro. Inhalation of siR-7-EM/KK-46 led to significant reduction of virus titer and lung inflammation in vivo, demonstrating its potential as a therapeutic strategy for COVID-19 patients.

ALLERGY (2021)

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Article Chemistry, Multidisciplinary

Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration

Siva P. Kambhampati et al.

Summary: The study demonstrates a potential systemic therapy approach for selectively targeting and inhibiting the progression of AMD, showing promising efficacy in animal models and human postmortem studies.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Organic

Hybrid phosphorus-viologen dendrimers as new soft nanoparticles: design and properties

Jean-Pierre Majoral et al.

Summary: A variety of dendritic structures have been prepared, with a focus on phosphorus dendrimers and viologen dendrimers, which have shown promise in various fields. Combining phosphorus and viologen structures has led to the development of mixed hybrid phosphorus-viologen dendrimers, showcasing specific properties and applications in constructing organic-inorganic hybrid materials. Preliminary results on the biological properties of these nano-objects have been presented.

ORGANIC CHEMISTRY FRONTIERS (2021)

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Review Nanoscience & Nanotechnology

Dendrimer Architectonics to Treat Cancer and Neurodegenerative Diseases with Implications in Theranostics and Personalized Medicine

Hariharan Moorthy et al.

Summary: Theranostics, integrating diagnostic and therapeutic functions in a single platform, allows for noninvasive detection and treatment while monitoring disease progression and therapeutic efficacy in conditions like cancer and Alzheimer's disease. Theranostic tools can function independently or with the assistance of carriers like liposomes, micelles, polymers, or dendrimers, offering multifunctional properties for simultaneous imaging and drug delivery.

ACS APPLIED BIO MATERIALS (2021)

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Article Obstetrics & Gynecology

Two phase 3, double-blind, placebo-controlled studies of the efficacy and safety of Astodrimer 1% Gel for the treatment of bacterial vaginosis

Steven E. Chavoustie et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2020)

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Article Multidisciplinary Sciences

A phase 2, double-blind, multicenter, randomized, placebo-controlled, dose-ranging study of the efficacy and safety of Astodrimer Gel for the treatment of bacterial vaginosis

Arthur S. Waldbaum et al.

PLOS ONE (2020)

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Review Chemistry, Multidisciplinary

Spruce milled wood lignin: linear, branched or cross-linked?

Mikhail Balakshin et al.

GREEN CHEMISTRY (2020)

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Review Pharmacology & Pharmacy

Dendrimer Based Nanoarchitectures in Diabetes Management: An Overview

Vijay Mishra et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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Review Biochemistry & Molecular Biology

Nanotherapeutics for the Treatment of Cancer and Arthritis

Pal Patel et al.

CURRENT DRUG METABOLISM (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Advocating the Development of Next-Generation High-Relaxivity Gadolinium Chelates for Clinical Magnetic Resonance

Val M. Runge et al.

INVESTIGATIVE RADIOLOGY (2018)

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Review Materials Science, Multidisciplinary

Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers

Jean Pierre Majoral et al.

SCIENCE CHINA-MATERIALS (2018)

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Review Engineering, Biomedical

Review of core-multishell nanostructured models for nano-biomedical and nano-biopharmaceutical application

Ana J. Setrajcic-Tomic et al.

BIO-MEDICAL MATERIALS AND ENGINEERING (2018)

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Article Biotechnology & Applied Microbiology

Scalable synthesis and validation of PAMAM dendrimer-N-acetyl cysteine conjugate for potential translation

Rishi Sharma et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2018)

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Review Nanoscience & Nanotechnology

Nanoparticulate Contrast Agents for Multimodality Molecular Imaging

Yang Xia et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016)

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Article Immunology

Soluble Immune Mediators and Vaginal Bacteria Impact Innate Genital Mucosal Antimicrobial Activity in Young Women

Rebecca Pellett Madan et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

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Review Chemistry, Multidisciplinary

The dendrimer paradox - high medical expectations but poor clinical translation

Sonke Svenson

CHEMICAL SOCIETY REVIEWS (2015)

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Review Instruments & Instrumentation

Multifunctional nanoparticles for use in theranostic applications

James T. Cole et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2015)

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Review Medicine, Research & Experimental

Nanotheranostics - Application and Further Development of Nanomedicine Strategies for Advanced Theranostics

Madaswamy S. Muthu et al.

THERANOSTICS (2014)

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Review Biochemistry & Molecular Biology

Glycogen and its metabolism: some new developments and old themes

Peter J. Roach et al.

BIOCHEMICAL JOURNAL (2012)

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Article Immunology

Measurement of Mucosal Biomarkers in a Phase 1 Trial of Intravaginal 3% StarPharma LTD 7013 Gel (VivaGel) to Assess Expanded Safety

Anna-Barbara Moscicki et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2012)

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Article Public, Environmental & Occupational Health

Tell Juliana: Acceptability of the Candidate Microbicide VivaGelA® and Two Placebo Gels Among Ethnically Diverse, Sexually Active Young Women Participating in a Phase 1 Microbicide Study

Alex Carballo-Dieguez et al.

AIDS AND BEHAVIOR (2012)

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Article Immunology

Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)

Ian McGowan et al.

AIDS (2011)

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Article Multidisciplinary Sciences

A Phase I Randomized Placebo Controlled Trial of the Safety of 3% SPL7013 Gel (VivaGel®) in Healthy Young Women Administered Twice Daily for 14 Days

Craig R. Cohen et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

Clare F. Price et al.

PLOS ONE (2011)

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Article Infectious Diseases

Safety, Tolerability, and Pharmacokinetics of SPL7013 Gel (VivaGel®): A Dose Ranging, Phase I Study

John O'Loughlin et al.

SEXUALLY TRANSMITTED DISEASES (2010)

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Article Immunology

A Randomized Controlled Trial of the Safety of Candidate Microbicide SPL7013 Gel When Applied to the Penis

Marcus Y. Chen et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2009)

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Article Public, Environmental & Occupational Health

Attitudes of men in an Australian male tolerance study towards microbicide use

Wendy R. Holmes et al.

SEXUAL HEALTH (2008)

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Review Medicine, Research & Experimental

Dendrimers as drugs: Discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention

Tom D. McCarthy et al.

MOLECULAR PHARMACEUTICS (2005)

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Article Radiology, Nuclear Medicine & Medical Imaging

MR coronary angiography with SH L 643 A: Initial experience in patients with coronary artery disease

CU Herborn et al.

RADIOLOGY (2004)

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Article Chemistry, Multidisciplinary

Dendrislides, dendrichips: a simple chemical functionalization of glass slides with phosphorus dendrimers as an effective means for the preparation of biochips

E Trevisiol et al.

NEW JOURNAL OF CHEMISTRY (2003)

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