期刊
ISCIENCE
卷 25, 期 11, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2022.105455
关键词
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资金
- Departament de Salut of the Generalitat de Catalunya [SLD0016, SLD015]
- Carlos III Health Institute [PI17/01518, PI18/01332]
- Ministerio de Ciencia, Innovacion y Universidades (MICINN) [PID2020- 119710RB-I00]
- CERCA Program [2017SGR 252]
- Generalitat deCatalunya and Fons Social Europeu [2020 FI_B_0742]
- National Agency for Research and Development of Chile [ANID: 72180406]
- CIBER - Consorcio Centro deInvestigacion Biomedica en Red
- Carlos III Health Institute, Ministerio de Ciencia e Innovacion and Union Europea - NextGenerationEU
Mass vaccination campaigns have been effective in reducing COVID-19 transmission and severity. However, the immune responses developed in patients with predominantly antibody-deficiencies (PAD) after vaccination vary. Different PAD patients show different levels of response to the vaccine, highlighting the need for immunomonitoring and personalized therapeutic strategies.
Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunoderiency: unclassified primary antibody-deficiency (unPAD, n = 9), common variable immunodeficiency (CVID, n = 12), combined immunodeficiency (CID, n = 1), and thymoma with immunodeficiency (TID, n = 1). unPAD patients and healthy controls (HCs, n = 10) developed similar vaccine-induced humoral responses after two doses. However, CVID patients showed reduced binding and neutralizing titers compared to HCs. Of interest, these PAD groups showed lower levels of Spike-specific IFN-gamma-producing cells. CVID individuals also presented diminished CD8(+)T cells. CID and TID patients developed cellular but not humoral responses. Although the third vaccine dose boosted humoral responses in most PAD patients, it had limited effect on expanding cellular immunity. Vaccine-induced immune responses in PAD individuals are heterogeneous, and should be immunomonitored to define a personalized therapeutic strategies.
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