期刊
JOURNAL OF MICROBIOLOGY
卷 55, 期 1, 页码 1-12出版社
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-017-6452-1
关键词
antimicrobial peptide; therapies; drug candidate; pathogenic bacteria
类别
资金
- National Research Foundation of Korea [22A20130012098] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.
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