☆ 4.7 Article

Loss of Chemerin in Rhabdomyosarcoma Cells Polarizes Adjacent Monocytes to an Immunosuppressive Phenotype

BIOMEDICINES (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Molecular analysis of 10 pleomorphic rhabdomyosarcomas reveals potential prognostic markers and druggable targets

Zachary L. Chelsky et al.

Summary: Pleomorphic rhabdomyosarcoma (PRMS) is a rare and aggressive adult sarcoma with poor response to conventional treatments and lack of targeted therapies. Comprehensive molecular profiling is urgently needed for PRMS to identify potential actionable targets. Integrated molecular characterization has not only identified targetable alterations but also prognostic markers for stratifying PRMS patients.

GENES CHROMOSOMES & CANCER (2022)

添加到收藏夹

Letter Dentistry, Oral Surgery & Medicine

Identification of a novel RAB3IP-HMGA2 fusion transcript in an adult head and neck rhabdomyosarcoma

Alessandro De Vita et al.

ORAL DISEASES (2022)

添加到收藏夹

Letter Biochemistry & Molecular Biology

Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1

Chenxi Gao et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2022)

添加到收藏夹

Article Oncology

Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1

Dandan Lin et al.

Summary: Tumoral-released IL-1α promotes tumor development by inhibiting T cell activation and recruiting MDSCs, while systemic IL-1α protein inhibits tumor development and activates T cell responses. Additionally, calpain 1 is identified as a major intracellular protease mediating tumoral IL-1α secretion.

ONCOIMMUNOLOGY (2022)

添加到收藏夹

Review Oncology

Non-coding RNA in rhabdomyosarcoma progression and metastasis

Farah Ramadan et al.

Summary: Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children and adolescents, and non-coding RNA (ncRNA) play important roles in its development and progression, including microRNA, long non-coding RNA, circular RNA, and ribosomal RNA. Further investigation of the mechanisms of these ncRNA could provide potential targets and therapeutic agents for the treatment and prognosis of RMS.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Oncology

Advances in the treatment of pediatric solid tumors: A 50-year perspective

Michael P. LaQuaglia et al.

Summary: The incidence of cancer in children and adolescents is high in the United States. Significant progress has been made in the field of pediatric solid tumors, particularly in the treatment of neuroblastoma, Wilms tumor, rhabdomyosarcoma, and hepatoblastoma. The molecular driver for fibrolamellar hepatocellular carcinoma occurring in adolescents and young adults has also been identified.

JOURNAL OF SURGICAL ONCOLOGY (2022)

添加到收藏夹

Review Rheumatology

TNF in the era of immune checkpoint inhibitors: friend or foe?

Allen Y. Chen et al.

Summary: TNF inhibitors are commonly used to treat immune-related adverse events induced by immune checkpoint inhibitors, and evidence suggests that short courses of TNF inhibitors are safe for treating these events in cancer patients undergoing ICI therapy. Preclinical studies hint that TNF inhibition might enhance the antitumour effect of ICI therapy while ameliorating immune-related adverse events.

NATURE REVIEWS RHEUMATOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy

Jinhua Liu et al.

Summary: Programmed death protein 1 (PD1) is an important immune checkpoint on T cells that plays a crucial role in downregulating the immune system and promoting self-tolerance, while its ligand, programmed cell death ligand 1 (PDL1), is overexpressed in malignant tumor cells, contributing to immune evasion and treatment failure. Despite the clinical efficacy of PD1/PDL1 inhibitors in many tumors, some patients may develop drug resistance, highlighting the need for further research into improving targeted therapies and understanding the associated safety issues.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Oncology

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting

Kang Yi Lee et al.

Summary: CD137 expression on RMS tissue complicates treatment, with RMS cells hijacking the transfer of CD137 to evade immune surveillance and promote metastasis and poor prognosis. However, the ectopic expression of CD137 on RMS cells also provides an Achilles' heel for immunotherapy.

ONCOIMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas

Alessandro De Vita et al.

Summary: Adult rhabdomyosarcoma is a rare entity with limited research on its molecular biology and pharmacological characteristics. Understanding these aspects could provide valuable insights for clinical management and potential therapeutic targets for this poorly understood disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Immunology

Biology and therapeutic potential of interleukin-10

Margarida Saraiva et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Review Pathology

The current landscape of rhabdomyosarcomas: an update

Julia Leiner et al.

VIRCHOWS ARCHIV (2020)

添加到收藏夹

Article Oncology

Chemerin Reactivates PTEN and Suppresses PD-L1 in Tumor Cells via Modulation of a Novel CMKLR1-mediated Signaling Cascade

Keith Rennier et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation

Susanne Feder et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

Valerio Gelfo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chemerin Isoforms and Activity in Obesity

Christa Buechler et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chemerin and Cancer

Oliver Treeck et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer

Kerry B. Goralski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article

Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2

Dinesh J. Kumar et al.

Oncotarget (2019)

添加到收藏夹

Article Medicine, General & Internal

Rhabdomyosarcoma

Stephen X. Skapek et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

添加到收藏夹

Review Medicine, General & Internal

Inflammation and Cancer

Nitin Singh et al.

ANNALS OF AFRICAN MEDICINE (2019)

添加到收藏夹

Article Oncology

Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis

Jing-Jing Li et al.

BRITISH JOURNAL OF CANCER (2018)

添加到收藏夹

Review Immunology

Regulation and Function of the PD-L1 Checkpoint

Chong Sun et al.

IMMUNITY (2018)

添加到收藏夹

Review Immunology

Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

Woo Jae Shin et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Expression of chemerin correlates with a poor prognosis in female breast cancer patients

Ghada El-Sagheer et al.

BREAST CANCER-TARGETS AND THERAPY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chemerin has a protective role in hepatocellular carcinoma by inhibiting the expression of IL-6 and GM-CSF and MDSC accumulation

Y. Lin et al.

ONCOGENE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

Hui Xiao et al.

PLOS ONE (2017)

添加到收藏夹

Article Pathology

Rhabdomyosarcoma, Spindle Cell/Sclerosing Variant: A Clinical and Histopathological Examination of this Rare Variant with Three New Cases from the Oral Cavity

Molly Housley Smith et al.

HEAD & NECK PATHOLOGY (2017)

添加到收藏夹

Article Oncology

Assessment of Programmed Death-Ligand 1 Expression and Tumor-Associated Immune Cells in Pediatric Cancer Tissues

Robbie G. Majzner et al.

CANCER (2017)

添加到收藏夹

Review Medicine, Research & Experimental

From mice to humans: developments in cancer immunoediting

Michele W. L. Teng et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

添加到收藏夹

Article Dentistry, Oral Surgery & Medicine

Overexpression of chemerin was associated with tumor angiogenesis and poor clinical outcome in squamous cell carcinoma of the oral tongue

Ning Wang et al.

CLINICAL ORAL INVESTIGATIONS (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice

Jillian L. Rourke et al.

JOURNAL OF ENDOCRINOLOGY (2014)

添加到收藏夹

Article Oncology

Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

Jane Renshaw et al.

CLINICAL CANCER RESEARCH (2013)

添加到收藏夹

Article Cell Biology

Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis

Mark E. Issa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chemerin regulates proliferation and differentiation of myoblast cells via ERK1/2 and mTOR signaling pathways

Huansheng Yang et al.

CYTOKINE (2012)

添加到收藏夹

Article Immunology

The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses

Russell K. Pachynski et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

Benjamin Bondue et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2011)

添加到收藏夹

Article Endocrinology & Metabolism

Chemerin Exacerbates Glucose Intolerance in Mouse Models of Obesity and Diabetes

Matthew C. Ernst et al.

ENDOCRINOLOGY (2010)

添加到收藏夹

Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

添加到收藏夹

Article Oncology

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells

Chun-Liang Chen et al.

BMC CANCER (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.