期刊
BIOMEDICINES
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10102574
关键词
allergy; asthma; eosinophils; immune health; natural therapeutics
资金
- Hofseth BioCare, Kipervikgata, Alesund, Norway [R_21_224_003]
OmeGo, an enzymatically liberated fish oil, has demonstrated antioxidant and anti-inflammatory properties including the reduction of eosinophilia. In a mouse model of induced asthma, OmeGo showed a significant reduction in eosinophilic lung and systemic inflammation and reduced lung remodeling compared to cod liver oil. The CRTH2 antagonist fevipiprant showed a similar anti-inflammatory profile to OmeGo. OmeGo has the potential to be a pragmatic, cost-effective co-treatment for less severe forms of eosinophilic asthma.
Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been made for enhancing the control of moderate asthma. However, a number of moderate asthma sufferers remain troubled by unresolved symptoms, treatment side effects, or both. OmeGo, an enzymatically liberated fish oil, has demonstrated antioxidant and anti-inflammatory properties including the reduction of eosinophilia. A house dust mite model of induced asthma in mice was utilized in this study, and OmeGo showed a significant reduction in eosinophilic lung and systemic inflammation and reduced lung remodelling compared to cod liver oil. The CRTH2 antagonist fevipiprant showed an anti-inflammatory profile similar to that of OmeGo. OmeGo has the potential to be a pragmatic, cost-effective co-treatment for less severe forms of eosinophilic asthma. Proof-of-concept studies are planned.
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