4.7 Review

Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial

C. E. Geyer et al.

Summary: This study demonstrates that the addition of carboplatin to neoadjuvant chemotherapy can improve the pathological complete response rates in patients with triple-negative breast cancer without increasing the risk of side effects or secondary malignancies.

ANNALS OF ONCOLOGY (2022)

Article Oncology

RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors

Anne Roulston et al.

Summary: RP-3500 is a novel ATR kinase inhibitor with high selectivity and efficacy in protecting genome integrity and potential anti-tumor activity in xenograft models. The use of intermittent dosing schedules maximizes tumor growth inhibition and demonstrates the reversible nature of erythroid toxicity.

MOLECULAR CANCER THERAPEUTICS (2022)

Review Biochemistry & Molecular Biology

Review Hallmarks of DNA replication stress

Sneha Saxena et al.

Summary: Faithful DNA replication is crucial for maintaining genomic integrity. However, the replication process is constantly challenged by DNA damage and other stresses, collectively known as replication stress. Cells have evolved complex cellular responses to cope with replication stress and maintain genomic stability.

MOLECULAR CELL (2022)

Article Biology

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Hiroyuki Ueno et al.

Summary: In this study, we discovered a small-molecule inhibitor TAS1553 that targets the protein-protein interaction between R1 and R2 subunits of ribonucleotide reductase. TAS1553 showed high potency and selectivity, and effectively inhibited the proliferation of cancer cells by reducing the intracellular dATP pool and causing DNA replication stress.

COMMUNICATIONS BIOLOGY (2022)

Review Oncology

Recent advances in therapeutic strategies for triple-negative breast cancer

Yun Li et al.

Summary: Triple-negative breast cancer (TNBC) is a highly malignant subtype of breast cancer with a poor prognosis. Current treatment options are limited, but targeted therapies focusing on DNA repair pathways, androgen receptor signaling pathways, kinases, and immunotherapy have shown promise.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

DNA-PKcs promotes fork reversal and chemoresistance

Diego Dibitetto et al.

Summary: DNA-PKcs kinase plays a crucial role in the repair of DNA double-strand breaks and the control of fork dynamics. It promotes fork reversal, stabilizes stressed replication forks, and protects genome integrity. Inhibiting DNA-PKcs can restore chemotherapy sensitivity in BRCA2-deficient tumors.

MOLECULAR CELL (2022)

Article Oncology

First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors

Timothy A. Yap et al.

Summary: The study demonstrated that oral ATR inhibitor BAY 1895344 is well tolerated and effective in treating patients with advanced solid tumors, with some patients achieving partial responses or stable disease, particularly in those with DDR defects such as ATM loss. Further investigation is warranted to explore its potential in this patient population.

CANCER DISCOVERY (2021)

Article Oncology

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

Mark T. J. van Bussel et al.

Summary: This phase 1 trial aimed to determine the maximum-tolerated dose and recommended phase 2 dose of peposertib, a DNA-dependent protein kinase inhibitor, in patients with advanced solid tumors. Peposertib was well-tolerated and showed modest efficacy in unselected tumors, with the recommended dose declared as 400 mg twice daily. Further studies are ongoing with peposertib/chemo-radiation combinations.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer

Tanya E. Keenan et al.

Summary: This study investigated the efficacy of the WEE1 inhibitor adavosertib in combination with cisplatin for metastatic triple-negative breast cancer. Results showed some patients benefited clinically, but the overall objective response rate did not meet the predefined threshold, with treatment-related adverse events being common. Further validation of immune-infiltrated tumors in patients with clinical benefit is warranted.

CLINICAL CANCER RESEARCH (2021)

Article Cell Biology

Replication stress: from chromatin to immunity and beyond Yea-Lih Lin and Philippe Pasero

Yea-Lih Lin et al.

Summary: Replication stress, a hallmark of cancer cells, leads to increased genomic instability. It occurs when replication forks encounter obstacles, and is signaled by checkpoint kinases to prevent collapse. Chromatin remodelers also play a role in restarting forks. Recent studies have explored the interplay between stalled forks and innate immunity, offering new possibilities for cancer therapy.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2021)

Article Cell Biology

Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers

Daniel J. McGrail et al.

Summary: This study revealed that the replication stress response (RSR) defect gene expression signature can accurately identify patients who may benefit from immune checkpoint blockade (ICB) across various nonhypermutated tumor types, and inducing RSR defects pharmacologically may further expand the benefits of ICB to a larger patient population.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Oncology

An Overview of PARP Inhibitors for the Treatment of Breast Cancer

Laura Cortesi et al.

Summary: Loss-of-function mutations in BRCA1 and BRCA2 are detected in at least 5% of unselected patients with breast cancer, and PARP inhibitors such as Olaparib and talazoparib have demonstrated significant progression-free survival benefits for some patients. Additional studies are ongoing to explore the efficacy and safety of PARP inhibitors in different patient populations and in combination therapies.

TARGETED ONCOLOGY (2021)

Article Oncology

Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours

Mark R. Middleton et al.

Summary: The study demonstrated that berzosertib + gemcitabine is well tolerated in patients with advanced solid tumors and showed preliminary signs of efficacy. Berzosertib 210 mg/m(2) + gemcitabine 1000 mg/m(2) Q3W was established as the recommended Phase 2 dose.

BRITISH JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Ke Cong et al.

Summary: Mutations in BRCA1 or BRCA2 are found to be synthetic lethal with PARPi, with toxicity deriving from replication gaps instead of DNA double-stranded breaks. The study uncouples HR, FP, and fork speed from PARPi response, highlighting gaps as a determinant of PARPi toxicity and changing the paradigm for synthetic lethal interactions.

MOLECULAR CELL (2021)

Review Oncology

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

Ukhyun Jo et al.

Summary: This article discusses research on replication stress in cancer and proposes strategies for utilizing RepStress-targeted therapies. Precision medicine can improve cancer diagnosis and treatment by developing treatment strategies based on the molecular characteristics of tumors. The article also mentions targeting replication, checkpoint, and repair pathways through ATR inhibitors and SLFN11 as predictive biomarkers.

CANCERS (2021)

Article Oncology

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression

Martina Proctor et al.

Summary: Targeted therapies focusing on replication stress have shown promising results in selectively killing tumors while also enhancing immune response for effective tumor control. Despite some challenges in clinical translation, these therapies offer potential for improving cancer treatment outcomes.

CANCERS (2021)

Article Oncology

Proteomics-derived basal biomarker DNA-PKcs is associated with intrinsic subtype and long-term clinical outcomes in breast cancer

Karama Asleh et al.

Summary: The study revealed a significant association between high DNA-PKcs expression and stromal and CD8+ tumor infiltrating lymphocytes, with tumors in the basal-like subtype displaying the most favorable survival when having low DNA-PKcs and high tumor-infiltrating lymphocytes. Integrating DNA-PKcs expression with immune biomarkers could provide guidance for patient selection for targeted strategies in basal-like breast cancer.

NPJ BREAST CANCER (2021)

Review Medicine, Research & Experimental

Targeting DNA repair pathway in cancer: Mechanisms and clinical application

Manni Wang et al.

Summary: Understanding DDR pathways has broadened the landscape of oncology therapy, with genomic instability from deficient DDR contributing to cancer occurrence. Exploiting these defects as therapeutic opportunities, DDR inhibitors have rapidly expanded to target various pathways involved, showing potential in cancer treatment.

MEDCOMM (2021)

Review Oncology

Targeting the replication stress response through synthetic lethal strategies in cancer medicine

Natalie Y. L. Ngoi et al.

Summary: The replication stress response (RSR) is crucial for maintaining genomic integrity in the presence of elevated replicative stress, with increasing dependence of cancers on RSR. Drug candidates targeting key RSR nodes show promising efficacy in early phase trials, offering potential for overcoming PARP inhibitor resistance.

TRENDS IN CANCER (2021)

Review Oncology

Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy

Katherine E. Baillie et al.

Summary: DNA replication stress is a common state in many cancers, and targeting replication stress response factors such as ATR and CHK1 kinases is a promising therapeutic approach. However, research revealing the complexity of the replication stress response suggests new genetic interactions and candidate therapeutic targets. Many of these candidates regulate DNA transactions around reversed replication forks, including helicases, nucleases, and alternative polymerases that promote fork stability and restart.

TRENDS IN CANCER (2021)

Article Immunology

Human DNA-PK activates a STING-independent DNA sensing pathway

Katelyn Burleigh et al.

SCIENCE IMMUNOLOGY (2020)

Review Oncology

Role of DNA repair defects in predicting immunotherapy response

Jing Zhang et al.

BIOMARKER RESEARCH (2020)

Review Cell Biology

The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

Matteo Berti et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Alexy Promonet et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Exploiting DNA Replication Stress for Cancer Treatment

Tajinder Ubhi et al.

CANCER RESEARCH (2019)

Review Biochemistry & Molecular Biology

Replication-Coupled DNA Repair

David Cortez

MOLECULAR CELL (2019)

Review Cell Biology

Defining and Modulating 'BRCAness'

Andrea K. Byrum et al.

TRENDS IN CELL BIOLOGY (2019)

Review Cell Biology

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

Sylvie M. Noordermeer et al.

TRENDS IN CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis

Marianne Samir Makboul Issac et al.

NEOPLASIA (2019)

Review Pharmacology & Pharmacy

Targeting the replication stress response in cancer

Josep V. Forment et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Oncology

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

Julie M. Diamond et al.

CANCER IMMUNOLOGY RESEARCH (2018)

Article Genetics & Heredity

Mechanisms of PARP inhibitor sensitivity and resistance

Alan D. D'Andrea

DNA REPAIR (2018)

Article Multidisciplinary Sciences

High speed of fork progression induces DNA replication stress and genomic instability

Apolinar Maya-Mendoza et al.

NATURE (2018)

Article Multidisciplinary Sciences

SAMHD1 acts at stalled replication forks to prevent interferon induction

Flavie Coquel et al.

NATURE (2018)

Article Medicine, General & Internal

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

Jennifer K. Litton et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Targeting ATR in cancer

Emilio Lecona et al.

NATURE REVIEWS CANCER (2018)

Article Oncology

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Eileen E. Parkes et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Eileen E. Parkes et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Review Biochemistry & Molecular Biology

Replication Fork Reversal: Players and Guardians

Annabel Quinet et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

cGAS surveillance of micronuclei links genome instability to innate immunity

Karen J. Mackenzie et al.

NATURE (2017)

Review Genetics & Heredity

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Herve Techer et al.

NATURE REVIEWS GENETICS (2017)

Article Medicine, General & Internal

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

Mark Robson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

Hiro Sato et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Replication fork reversal triggers fork degradation in BRCA2-defective cells

Sofija Mijic et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

The prognostic significance of Cdc6 and Cdt1 in breast cancer

Ravikiran Mahadevappa et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer

Miroslava Jurikova et al.

ACTA HISTOCHEMICA (2016)

Article Multidisciplinary Sciences

Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

Ting Han et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Replication stress: getting back on track

Matteo Berti et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Targeting BRCA1-and BRCA2-deficient cells with RAD52 small molecule inhibitors

Fei Huang et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

Xia Ding et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

Chris T. Williamson et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Replication stress: getting back on track

Matteo Berti et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Oncology

BRCAness revisited

Christopher J. Lord et al.

NATURE REVIEWS CANCER (2016)

Article Cell Biology

DNA2 drives processing and restart of reversed replication forks in human cells

Saravanabhavan Thangavel et al.

JOURNAL OF CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress

Yu-Hung Chen et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Remi Buisson et al.

MOLECULAR CELL (2015)

Article Oncology

TIPIN depletion leads to apoptosis in breast cancer cells

Celine Baldeyron et al.

MOLECULAR ONCOLOGY (2015)

Review Biotechnology & Applied Microbiology

Exploiting replicative stress to treat cancer

Matthias Dobbelstein et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Review Cell Biology

DNA replication origin activation in space and time

Michalis Fragkos et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

ATR inhibition preferentially targets homologous recombination-deficient tumor cells

M. Krajewska et al.

ONCOGENE (2015)

Review Oncology

Replication stress and cancer

Helene Gaillard et al.

NATURE REVIEWS CANCER (2015)

Review Cell Biology

Causes and consequences of replication stress

Michelle K. Zeman et al.

NATURE CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

Luis Ignacio Toledo et al.

Article Biochemistry & Molecular Biology

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Monica M. Olcina et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

Homologous recombination and its regulation

Lumir Krejci et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Oncology

Balancing repair and tolerance of DNA damage caused by alkylating agents

Dragony Fu et al.

NATURE REVIEWS CANCER (2012)

Review Multidisciplinary Sciences

An oncogene-induced DNA damage model for cancer development

Thanos D. Halazonetis et al.

SCIENCE (2008)

Review Biotechnology & Applied Microbiology

Cellular processing of platinum anticancer drugs

D Wang et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Cell Biology

ATR and ATM regulate the timing of DNA replication origin firing

D Shechter et al.

NATURE CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

L Zou et al.

SCIENCE (2003)

Review Oncology

5-Fluorouracil: Mechanisms of action and clinical strategies

DB Longley et al.

NATURE REVIEWS CANCER (2003)

Article Medicine, Research & Experimental

Apoptosis in normal tissues induced by anti-cancer drugs

T Tamaki et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2003)

Review Cell Biology

Checking on the fork: the DNA-replication stress-response pathway

AJ Osborn et al.

TRENDS IN CELL BIOLOGY (2002)

Review Cell Biology

Cell cycle checkpoint signaling through the ATM and ATR kinases

RT Abraham

GENES & DEVELOPMENT (2001)

Article Multidisciplinary Sciences

Rapid destruction of human Cdc25A in response to DNA damage

N Mailand et al.

SCIENCE (2000)