期刊
BIOMEDICINES
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10092304
关键词
innate immunity; Drosophila model; NF-kappa B pathways; dynamic regulation; epigenetics
资金
- IdEx Unistra [ANR-10-IDEX-0002]
- SFRI-STRAT'US project [ANR 20-SFRI-0012]
- EUR IMCBio [ANR-17-EURE-0023]
- ANR [ANR-19-CE15-0017-01]
Metazoans have developed an immune system to protect themselves from pathogenic attack. The activation of NF-kappa B signaling pathways in the innate immune system provides a fast response, but uncontrolled activation can lead to inflammatory diseases or cancer. Using the Drosophila model, we can study the regulation of NF-kappa B pathways and gain general insights relevant to humans.
Metazoans have developed strategies to protect themselves from pathogenic attack. These preserved mechanisms constitute the immune system, composed of innate and adaptive responses. Among the two kinds, the innate immune system involves the activation of a fast response. NF-kappa B signaling pathways are activated during infections and lead to the expression of timely-controlled immune response genes. However, activation of NF-kappa B pathways can be deleterious when uncontrolled. Their regulation is necessary to prevent the development of inflammatory diseases or cancers. The similarity of the NF-kappa B pathways mediating immune mechanisms in insects and mammals makes Drosophila melanogaster a suitable model for studying the innate immune response and learning general mechanisms that are also relevant for humans. In this review, we summarize what is known about the dynamic regulation of the central NF-kappa B-pathways and go into detail on the molecular level of the IMD pathway. We report on the role of the nuclear protein Akirin in the regulation of the NF-kappa B Relish immune response. The use of the Drosophila model allows the understanding of the fine-tuned regulation of this central NF-kappa B pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据