4.7 Article

OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis

Jing Yang et al.

Summary: This study demonstrates that Triptolide can alleviate inflammation and tissue damage caused by acute pancreatitis by inhibiting NF-kappa B transactivation, modulating immune cell responses, and activating the Nrf2-mediated antioxidative system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Medicine, Research & Experimental

Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review)

Vlad Padureanu et al.

Summary: Acute pancreatitis is a severe disease with a high prevalence and mortality rate. Oxidative stress and antioxidants play important roles in the development of the disease, although the mechanisms are still unclear. Further research is needed to understand the relationship between antioxidant levels, severity of the disease, and pancreatic enzyme activities. Antioxidant therapy could be a potential treatment option, but more information on its effectiveness is required.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Article Biochemistry & Molecular Biology

Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling

Mate Nagy-Penzes et al.

Summary: Acute pancreatitis is a worldwide challenge due to its increasing incidence and life-threatening course. The flavone compound, tricetin, shows potential protective effects in acute pancreatitis by reducing inflammation, necrosis, and oxidative DNA damage.

BIOMEDICINES (2022)

Review Medicine, Research & Experimental

Redox signaling at the crossroads of human health and disease

Jing Zuo et al.

Summary: Redox biology is crucial in life sciences, as redox processes are closely associated with biological activities. Redox homeostasis is essential for human health, where nonradical reactive oxygen species (ROS) function as key second messengers in modulating physiological redox signaling. However, excessive ROS accumulation, termed oxidative stress (OS), leads to biomolecule damage and the development of various diseases. Understanding the roles of redox signaling networks under physiological and pathological conditions is important for the development of redox medicine and treatment of redox-relevant diseases.

MEDCOMM (2022)

Article Pharmacology & Pharmacy

High-content screening identifies inhibitors of oxidative stress-induced parthanatos: cytoprotective and anti-inflammatory effects of ciclopirox

Zsolt Regdon et al.

Summary: The research identified ciclopirox and apomorphine as compounds that can inhibit PARP1-mediated cell death induced by hydrogen peroxide, demonstrating anti-inflammatory effects. These compounds achieve this by inhibiting PAR polymer synthesis and reducing mitochondrial superoxide production.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Immunology

Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model

Sapana Bansod et al.

Summary: In this study, it was found that NB effectively alleviated the severity of acute pancreatitis by reducing pancreatic edema, plasma enzyme levels, and inflammatory damage in pancreatic tissues. The antioxidant effect of NB inhibited oxidative-nitrosative stress and suppressed proinflammatory cytokines, resulting in reduced pancreatic apoptosis and inflammation, ultimately attenuating cerulein-induced acute pancreatitis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Bishoy M. F. Hanna et al.

BIOMOLECULES (2020)

Article Biotechnology & Applied Microbiology

Superoxide dismutase mimetic nanoceria restrains cerulein induced acute pancreatitis

Amit Khurana et al.

NANOMEDICINE (2019)

Review Genetics & Heredity

Generation, repair and replication of guanine oxidation products

Katsuhito Kino et al.

GENES AND ENVIRONMENT (2017)

Review Pathology

Poly(ADP-Ribose) Polymerases New Players in the Pathogenesis of Exocrine Pancreatic Diseases

Neus Martinez-Bosch et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

Review Gastroenterology & Hepatology

The role of pancreatic ducts in the pathogenesis of acute pancreatitis

Peter Hegyi et al.

PANCREATOLOGY (2015)

Article Immunology

Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1-KRAS-NF-κB Pathway

Leopoldo Aguilera-Aguirre et al.

JOURNAL OF IMMUNOLOGY (2014)

Review Biochemistry & Molecular Biology

Poly(ADP-ribose) signaling in cell death

Laszlo Virag et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice

Guoping Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Letter Gastroenterology & Hepatology

Insufficiency of Electrolyte and Fluid Secretion by Pancreatic Ductal Cells Leads to Increased Patient Risk for Pancreatitis

Peter Hegyi et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

New Advances in Cell Physiology and Pathophysiology of the Exocrine Pancreas

Joachim Moessner

DIGESTIVE DISEASES (2010)

Article

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

ATHANASIOS VALAVANIDIS et al.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2009)

Article Gastroenterology & Hepatology

Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis

S Ohashi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Medicine, Research & Experimental

Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury

RA Mota et al.

LABORATORY INVESTIGATION (2005)

Article Biochemistry & Molecular Biology

Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation

JG Mabley et al.

FASEB JOURNAL (2004)

Article Gastroenterology & Hepatology

Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis

CC Winterbourn et al.

PANCREATOLOGY (2003)