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Contribution of Adenosine in the Physiological Changes and Injuries Secondary to Exposure to Extreme Oxygen Pressure in Healthy Subjects

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Summary: The study found that elite freedivers have higher levels of adenosine in their blood at baseline and experience a greater increase in response to apnoea compared to control participants. Additionally, freedivers exhibited an increase in ADA levels in response to apnoea, as well as reduced ENT-1 levels and function. These results suggest that freedivers have an adaptive mechanism similar to individuals exposed to chronic hypoxia at high altitudes.

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