期刊
BIOMEDICINES
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10092275
关键词
white adipocyte; brown adipocyte; beige adipocyte; mammary gland; organ; obesity; subcutaneous fat; visceral fat
资金
- RSA 2016-2017 UnivPM
- PRIN 2017 [2017L8Z2EM]
Obesity is a major cause of death worldwide, and understanding the adipose organ is crucial for studying its pathology and formulating therapeutic strategies. This study utilized various techniques such as anatomical dissections and medical imaging to demonstrate that white and brown adipose tissues form a large, unified structure that can be considered a true organ. This finding was confirmed in both mice and humans.
Obesity is the fifth leading cause of death worldwide. In mice and humans with obesity, the adipose organ undergoes remarkable morpho-functional alterations. The comprehension of the adipose organ function and organization is of paramount importance to understand its pathology and formulate future therapeutic strategies. In the present study, we performed anatomical dissections, magnetic resonance imaging, computed axial tomography and histological and immunohistochemical assessments of humans and mouse adipose tissues. We demonstrate that most of the two types of adipose tissues (white, WAT and brown, BAT) form a large unitary structure fulfilling all the requirements necessary to be considered as a true organ in both species. A detailed analysis of the gross anatomy of mouse adipose organs in different pathophysiological conditions (normal, cold, pregnancy, obesity) shows that the organ consists of a unitary structure composed of different tissues: WAT, BAT, and glands (pregnancy). Data from autoptic dissection of 8 cadavers, 2 females and 6 males (Age: 37.5 +/- 9.7, BMI: 23 +/- 2.7 kg/m(2)) and from detailed digital dissection of 4 digitalized cadavers, 2 females and 2 males (Age: 39 +/- 14.2 years, BMI: 22.8 +/- 4.3 kg/m(2)) confirmed the mixed (WAT and BAT) composition and the unitary structure of the adipose organ also in humans. Considering the remarkable endocrine roles of WAT and BAT, the definition of the endocrine adipose organ would be even more appropriate in mice and humans.
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