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MOLECULAR & CELLULAR PROTEOMICS (2014)
Differential Expression of Cytochrome P450 Enzymes in Normal and Tumor Tissues from Childhood Rhabdomyosarcoma
Dora Molina-Ortiz et al.
PLOS ONE (2014)
Effect of pregnane X receptor expression on drug resistance in breast cancer
En-Qi Qiao et al.
ONCOLOGY LETTERS (2014)
Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis
Brahim Achour et al.
DRUG METABOLISM AND DISPOSITION (2014)
Evaluation of the HC-04 Cell Line as an In Vitro Model for Mechanistic Assessment of Changes in Hepatic Cytochrome P450 3A during Adenovirus Infection
Piyanuch Wonganan et al.
DRUG METABOLISM AND DISPOSITION (2014)
The role of vitamin D in reducing cancer risk and progression
David Feldman et al.
NATURE REVIEWS CANCER (2014)
Regulation of Intestinal Cytochrome P450 Expression by Hepatic Cytochrome P450: Possible Involvement of Fibroblast Growth Factor 15 and Impact on Systemic Drug Exposure
Yi Zhu et al.
MOLECULAR PHARMACOLOGY (2014)
Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects
Soo Lim et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2013)
The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system
Marcelo Ferder et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)
Vitamin D and Cardiovascular Health
Carl J. Lavie et al.
CIRCULATION (2013)
Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations
Ibrahim Ince et al.
CLINICAL PHARMACOKINETICS (2013)
Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension
Jorge Capdevila et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2013)
Influence of chronic hepatitis C infection on cytochrome P450 3a4 activity using midazolam as an in vivo probe substrate
P. N. Morcos et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)
A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail
Peter N. Morcos et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)
Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond
Xiaojuan Chai et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2013)
Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives
Hiroyuki Masuno et al.
JOURNAL OF LIPID RESEARCH (2013)
The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes
Maho Okubo et al.
JOURNAL OF TOXICOLOGICAL SCIENCES (2013)
Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis
Xiao-cong Zuo et al.
PHARMACOGENETICS AND GENOMICS (2013)
CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy
Laure Elens et al.
PHARMACOGENOMICS (2013)
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
Ulrich M. Zanger et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Human cytochromes P450 in health and disease
Daniel W. Nebert et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2013)
Isoform-Specific Regulation of Cytochromes P450 Expression by Estradiol and Progesterone
Su-Young Choi et al.
DRUG METABOLISM AND DISPOSITION (2013)
Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα)
Maria Thomas et al.
MOLECULAR PHARMACOLOGY (2013)
Comparison of Endogenous 4β-Hydroxycholesterol with Midazolam as Markers for CYP3A4 Induction by Rifampicin
Linda Bjorkhem-Bergman et al.
DRUG METABOLISM AND DISPOSITION (2013)
Bile Acid Metabolism and Signaling
John Y. L. Chiang
COMPREHENSIVE PHYSIOLOGY (2013)
Differential Expression of Human Cytochrome P450 Enzymes from the CYP3A Subfamily in the Brains of Alcoholic Subjects and Drug-Free Controls
Iris M. Booth Depaz et al.
DRUG METABOLISM AND DISPOSITION (2013)
Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage
Rene Huber et al.
CELLULAR SIGNALLING (2012)
Effect of Diabetes Mellitus on Pharmacokinetic and Pharmacodynamic Properties of Drugs
Miroslav Dostalek et al.
CLINICAL PHARMACOKINETICS (2012)
Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus
Manoranjenni Chetty et al.
CURRENT DRUG METABOLISM (2012)
Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture
Leslie J. Dickmann et al.
CURRENT DRUG METABOLISM (2012)
Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation
Hadi Molanaei et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Role of CAR and PXR in xenobiotic sensing and metabolism
Yue-Ming Wang et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
Dipak Panigrahy et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Anna C. Calkin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Pregnane X Receptor and Yin Yang 1 Contribute to the Differential Tissue Expression and Induction of CYP3A5 and CYP3A4
Dieudonne Nem et al.
PLOS ONE (2012)
Immunological response as a source to variability in drug metabolism and transport
Hege Christensen et al.
FRONTIERS IN PHARMACOLOGY (2012)
Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
Sumio Ohtsuki et al.
DRUG METABOLISM AND DISPOSITION (2012)
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases
Xizhen Xu et al.
ADVANCED DRUG DELIVERY REVIEWS (2011)
Constitutive Androstane Receptor Activation Decreases Plasma Apolipoprotein B-Containing Lipoproteins and Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
Anne-Laure Sberna et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease
Thierry Claudel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Inferring statin-induced gene regulatory relationships in primary human hepatocytes
Adrian Schroeder et al.
BIOINFORMATICS (2011)
Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus
Miroslav Dostalek et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
The cytochrome P450 pathway in angiogenesis and endothelial cell biology
Ingrid Fleming
CANCER AND METASTASIS REVIEWS (2011)
PPARs and Lipid Ligands in Inflammation and Metabolism
Gregory S. Harmon et al.
CHEMICAL REVIEWS (2011)
Evaluation of 6β-Hydroxycortisol, 6β-Hydroxycortisone, and a Combination of the Two as Endogenous Probes for Inhibition of CYP3A4 In Vivo
C-C Peng et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Disease-Drug-Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis
C. Schmitt et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture
Leslie J. Dickmann et al.
DRUG METABOLISM AND DISPOSITION (2011)
CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14, 15-Epoxyeicosatrienoic Acid (EET)
Ranjana Mitra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Cholesterol 25-hydroxylation activity of CYP3A
Akira Honda et al.
JOURNAL OF LIPID RESEARCH (2011)
Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection
Hirotaka Kawakami et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease
Yijing Zhang et al.
PLOS ONE (2011)
Gene Expression Profiling of Duodenal Biopsies Discriminates Celiac Disease Mucosa From Normal Mucosa
Hanna Bragde et al.
PEDIATRIC RESEARCH (2011)
Assessment of Pharmacologic Area Under the Curve When Baselines are Variable
Jeremy D. Scheff et al.
PHARMACEUTICAL RESEARCH (2011)
Impact of the CYP3A4*1G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients
Masatomo Miura et al.
PHARMACOGENOMICS (2011)
CYP3A4 and CYP3A5 Polymorphisms and Blood Pressure Response to Amlodipine among African-American Men and Women with Early Hypertensive Renal Disease
Vibha Bhatnagar et al.
AMERICAN JOURNAL OF NEPHROLOGY (2010)
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
Alexander Jetter et al.
ANTIVIRAL THERAPY (2010)
Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding
Monica A. Istrate et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Retinoids activate RXR/CAR-mediated pathway and induce CYP3A
Shiyong Chen et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Update Information on Drug Metabolism Systems-2009, Part II. Summary of Information on the Effects of Diseases and Environmental Factors on Human Cytochrome P450 (CYP) Enzymes and Transporters
Slobodan Rendic et al.
CURRENT DRUG METABOLISM (2010)
Variability in drug metabolizing enzyme activity in HIV-infected patients
Amanda E. Jones et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2010)
Metabolism considerations for kinase inhibitors in cancer treatment
Derek R. Duckett et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)
The Binary HCO3- Umbrella: A Unifying Hypothesis on Pathogenetic and Therapeutic Aspects of Fibrosing Cholangiopathies
Ulrich Beuers et al.
HEPATOLOGY (2010)
Profiling the expression of cytochrome P450 in breast cancer
Graeme I. Murray et al.
HISTOPATHOLOGY (2010)
The Anti-tumorigenic Properties of Peroxisomal Proliferator-activated Receptor α Are Arachidonic Acid Epoxygenase-mediated
Ambra Pozzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions
Saskia Preissner et al.
NUCLEIC ACIDS RESEARCH (2010)
Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism
Veronique Michaud et al.
PLOS ONE (2010)
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis
Shiling Yang et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)
The Structure-Activity Correlation on the Inhibitory Effects of Flavonoids on Cytochrome P450 3A Activity
Masayuki Tsujimoto et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)
Vitamin D and respiratory health
D. A. Hughes et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)
Impact of Infectious and Inflammatory Disease on Cytochrome P450-Mediated Drug Metabolism and Pharmacokinetics
E. T. Morgan
CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)
Transcriptional Regulation of Cytochrome P450 Genes by the Nuclear Receptor Hepatocyte Nuclear Factor 4-Alpha
Ramiro Jover et al.
CURRENT DRUG METABOLISM (2009)
Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
Fabien Dutheil et al.
DRUG METABOLISM AND DISPOSITION (2009)
Molecular Population Genetics of Human CYP3A Locus: Signatures of Positive Selection and Implications for Evolutionary Environmental Medicine
Xiaoping Chen et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2009)
High-Dose Ursodeoxycholic Acid for the Treatment of Primary Sclerosing Cholangitis
Keith D. Lindor et al.
HEPATOLOGY (2009)
Cytochrome P450-mediated metabolism in the human gut wall
Kirstin Thelen et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2009)
Unveiling a New Essential Cis Element for the Transactivation of the CYP3A4 Gene by Xenobiotics
Takayoshi Toriyabe et al.
MOLECULAR PHARMACOLOGY (2009)
Epidemiology of vitamin D in health and disease
Sihe Wang
NUTRITION RESEARCH REVIEWS (2009)
Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human
Maryam Rakhshandehroo et al.
PLOS ONE (2009)
Expression of Cytochrome P450 3A4 and Its Clinical Significance in Human Prostate Cancer
Tetsuya Fujimura et al.
UROLOGY (2009)
MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting
Yu-Zhuo Pan et al.
DRUG METABOLISM AND DISPOSITION (2009)
Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease
Craig D. Fisher et al.
DRUG METABOLISM AND DISPOSITION (2009)
The tangle of nuclear receptors that controls xenobiotic metabolism and transport: Crosstalk and consequences
Jean-Marc Pascussi et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2008)
PPARα gene expression is up-regulated by LXR and PXR activators in the small intestine
Jun Inoue et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4 alpha
Fu-Jun Liu et al.
BIOCHEMICAL JOURNAL (2008)
An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis
Sergey Y. Cheranov et al.
BLOOD (2008)
Mechanisms of Cholestasis
Gernot Zollner et al.
CLINICS IN LIVER DISEASE (2008)
Role of vitamin D receptor in the lithocholic acid- mediated CYP3A induction in vitro and in vivo
Tsutomu Matsubara et al.
DRUG METABOLISM AND DISPOSITION (2008)
Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription
Frank J. Gonzalez
DRUG METABOLISM AND PHARMACOKINETICS (2008)
Inflammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing
Marina Kacevska et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Expression and activity of taxane-metobolizing enzymes in ovarian tumors
Julie A. DeLoia et al.
GYNECOLOGIC ONCOLOGY (2008)
Post-transcriptional regulation of human pregnane x receptor by micro-RNA affects the expression of cytochrome P450 3A4
Shingo Takagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Drug Metabolism in Human Brain: High Levels of Cytochrome P4503A43 in Brain and Metabolism of Anti-Anxiety Drug Alprazolam to Its Active Metabolite
Varsha Agarwal et al.
PLOS ONE (2008)
Vascular cytochrome P450 enzymes: Physiology and pathophysiology
Ingrid Fleming
TRENDS IN CARDIOVASCULAR MEDICINE (2008)
PPAR alpha Ligands as Antitumorigenic and Antiangiogenic Agents
Ambra Pozzi et al.
PPAR RESEARCH (2008)
Fibrates and future PPAR alpha agonists in the treatment of cardiovascular disease
Bart Staels et al.
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2008)
Calcium and vitamin D: Skeletal and extraskeletal health
Natasha Khazai et al.
Current Rheumatology Reports (2008)
Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
Zofia Duniec-Dmuchowski et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Human pregnane x receptor and resistance to chemotherapy in prostate cancer
Yakun Chen et al.
CANCER RESEARCH (2007)
Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells
Hisashi Masuyama et al.
MOLECULAR PHARMACOLOGY (2007)
Gene-specific effects of inflammatory Cytokines on cytochrome P4502C, 2B6 and 3A4 mRNA levels in human Hepatocytes
Alison E. Aitken et al.
DRUG METABOLISM AND DISPOSITION (2007)
Transcription factor binding to a putative double e-box motif represses CYP3A4 expression in human lung cells
Jason S. Biggs et al.
MOLECULAR PHARMACOLOGY (2007)
Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
Ivan Bieche et al.
PHARMACOGENETICS AND GENOMICS (2007)
Cytochrome P450 epoxygenase promotes human cancer metastasis
Jian-Gang Jiang et al.
CANCER RESEARCH (2007)
Peroxisomal proliferator-activated receptor-α-dependent inhibition of endothelial cell proliferation and tumorigenesis
Ambra Pozzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4α :: Evidence for direct regulation in the intestine
Heike Tegude et al.
DRUG METABOLISM AND DISPOSITION (2007)
Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition
Yu Xue et al.
MOLECULAR ENDOCRINOLOGY (2007)
Anandamide metabolism by human liver and kidney microsomal cytochrome P450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides
Natasha T. Snider et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Characterization of androgen-regulated expression of CYP3A5 in human prostate
Anne-Mari Moilanen et al.
CARCINOGENESIS (2007)
Drugs as CYP3A probes, inducers, and inhibitors
Yi-Tong Liu et al.
DRUG METABOLISM REVIEWS (2007)
Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury
John M. Seubert et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2007)
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human Hepatocytes
Koki Kojima et al.
DRUG METABOLISM AND PHARMACOKINETICS (2007)
Epoxyeicosatrienoic acids, cell signaling and angiogenesis
Ingrid Fleming
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2007)
Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer
S. Leskela et al.
ENDOCRINE-RELATED CANCER (2007)
Pharmacogenetics of paclitaxel metabolism
Jennifer Spratlin et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2007)
Transcriptional repression of hepatic Cytochrome P450 3A4 gene in the presence of cancer
Kellie A. Charles et al.
CLINICAL CANCER RESEARCH (2006)
Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas
Susanne Haas et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Epidemiology of disease risks in relation to vitamin D insufficiency
William B. Grant
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2006)
Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts
M. Teresa Donato et al.
DRUG METABOLISM AND DISPOSITION (2006)
Poor correlation between 6β-hydroxycortisol:: cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity
Ya-Chi Chen et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2006)
Role of NF-κB in regulation of PXR-mediated gene expression -: A mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents
Xinsheng Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet
Kouichi Yoshinari et al.
PHARMACEUTICAL RESEARCH (2006)
Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor
Stephanie R. Faucette et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
The human intestinal cytochrome P450 pie
MF Paine et al.
DRUG METABOLISM AND DISPOSITION (2006)
Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4α and coactivators, and suppression of small heterodimer partner gene expression
TG Li et al.
DRUG METABOLISM AND DISPOSITION (2006)
Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers
J Ling et al.
DRUG METABOLISM AND DISPOSITION (2006)
Role of polymorphic human cytochrome P450 enzymes in estrone oxidation
AE Cribb et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2006)
Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis
BL Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1 alpha,25-dihydroxyvitamin D-3: Implications for drug-induced osteomalacia
Y Xu et al.
MOLECULAR PHARMACOLOGY (2006)
Transcriptional regulation of the human pregnane-X receptor
GG Gibson et al.
DRUG METABOLISM REVIEWS (2006)
Significance of the minor cytochrome P450 3A isoforms
AK Daly
CLINICAL PHARMACOKINETICS (2006)
Clinical pharmalcokinetics of docetaxel - Recent developments
SD Baker et al.
CLINICAL PHARMACOKINETICS (2006)
Transcriptional regulation of the PXR gene: Identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR
S Aouabdi et al.
DRUG METABOLISM AND DISPOSITION (2006)
Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cells
Liping Du et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)
Profiling cytochrome P450 expression in ovarian cancer:: Identification of prognostic markers
D Downie et al.
CLINICAL CANCER RESEARCH (2005)
CAR, the continuously advancing receptor, in drug metabolism and disease
M Qatanani et al.
CURRENT DRUG METABOLISM (2005)
Vitamin D and type 1 diabetes mellitus: state of the art
C Mathieu et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2005)
Variability of CYP3A7 expression in human fetal liver
JS Leeder et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Potential role for human cytochrome P450 3A4 in estradiol homeostasis
AM Yu et al.
ENDOCRINOLOGY (2005)
Evolution of the pregnane X receptor: Adaptation to cross-species differences in biliary bile salts
MD Krasowski et al.
MOLECULAR ENDOCRINOLOGY (2005)
Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity
K Aleksa et al.
PEDIATRIC NEPHROLOGY (2005)
Transcriptional regulation of the human hepatic CYP3A4:: Identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein β isoforms (liver activating protein and liver inhibitory protein)
CP Martínez-Jiménez et al.
MOLECULAR PHARMACOLOGY (2005)
Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests
SJ Lee et al.
PHARMACOGENOMICS (2005)
The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion
H Masuyama et al.
MOLECULAR ENDOCRINOLOGY (2005)
Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors
A Codina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Molecular and functional comparison of 1,25-dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4
PW Jurutka et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
Pharmacogenetic determinants of human liver microsomal alfeintanil metabolism and the role of cytochrome P450 3A5
TM Klees et al.
ANESTHESIOLOGY (2005)
Metabolism of alfentanil by cytochrome P4503A (CYP3A) enzymes
TM Klees et al.
DRUG METABOLISM AND DISPOSITION (2005)
Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis
C Frank et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Regulation of CYP3A genes in the human respiratory tract
H Raunio et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2005)
Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative
R Adachi et al.
JOURNAL OF LIPID RESEARCH (2005)
Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases
JD Imig
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Genetic variability in CYP3A5 and its possible consequences
HG Xie et al.
PHARMACOGENOMICS (2004)
Feed-forward regulation of bile acid detoxification by CYP3A4 - Studies in humanized transgenic mice
C Stedman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes
R Schmidt et al.
BRITISH JOURNAL OF CANCER (2004)
Identification of a novel polymorphic enhancer of the human CYP3A4 gene
K Matsumura et al.
MOLECULAR PHARMACOLOGY (2004)
Regulation of CYP3A4 by the bile acid receptor FXR:: evidence for functional binding sites in the CYP3A4 gene
C Gnerre et al.
PHARMACOGENETICS (2004)
The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR)
O Burk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Loss of CYP3 A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3 A7 gene
H Hara et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
CYP3A variation and the evolution of salt-sensitivity variants
EE Thompson et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
CAR, driving into the future
K Swales et al.
MOLECULAR ENDOCRINOLOGY (2004)
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism
WL Huang et al.
DRUG METABOLISM AND DISPOSITION (2004)
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
MF Holick
AMERICAN JOURNAL OF CLINICAL NUTRITION (2004)
Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes
T Langmann et al.
GASTROENTEROLOGY (2004)
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
J Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Estrogen regulation of the cytochrome P450 3A subfamily in humans
ET Williams et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Cytochrome P450 3A and their regulation
O Burk et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2004)
Expression of CYP3A4 in human breast tumour and non-tumour tissues
N Kapucuoglu et al.
CANCER LETTERS (2003)
Urinary 6β-hydroxycortisol:: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals
MM Galteau et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2003)
Expression and potential roles of pregnane X receptor in endometrial cancer
H Masuyama et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Characterization of the oxidative metabolites of 17β-estradiol and estrone formed by 15 selectively expressed human cytochrome P450 isoforms
AJ Lee et al.
ENDOCRINOLOGY (2003)
Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism
A Westlind-Johnsson et al.
DRUG METABOLISM AND DISPOSITION (2003)
Liver X receptors interact with corepressors to regulate gene expression
X Hu et al.
MOLECULAR ENDOCRINOLOGY (2003)
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein α and hepatocyte nuclear factor-3γ
C Rodríguez-Antona et al.
MOLECULAR PHARMACOLOGY (2003)
Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance
I Dussault et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
RG Tirona et al.
NATURE MEDICINE (2003)
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
B Goodwin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells
M Medhora et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)
Developmental expression of the major human hepatic CYP3A enzymes
JC Stevens et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle
MA Sarkar et al.
DRUG METABOLISM AND DISPOSITION (2003)
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid
CY Zhang et al.
STROKE (2002)
Genetic contribution to variable human CYP3A-mediated metabolism
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ADVANCED DRUG DELIVERY REVIEWS (2002)
Down-regulation of human CYP3A4 by the inflammatory signal interleukin 6:: molecular mechanism and transcription factors involved
R Jover et al.
FASEB JOURNAL (2002)
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7
JA Williams et al.
DRUG METABOLISM AND DISPOSITION (2002)
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
B Goodwin et al.
MOLECULAR PHARMACOLOGY (2002)
Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response
LP Rivory et al.
BRITISH JOURNAL OF CANCER (2002)
Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes
L Drocourt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism
YS Lin et al.
MOLECULAR PHARMACOLOGY (2002)
PXR, CAR and drug metabolism
TM Willson et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Intergenic mRNA molecules resulting from trans-splicing
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4
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MOLECULAR CELL (2002)
Fibrate and statin synergistically increase the transcriptional activities of PPARα/RXRα and decrease the transactivation of NFκB
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues
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INTERNATIONAL JOURNAL OF CANCER (2002)
Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man
GG Gibson et al.
XENOBIOTICA (2002)
Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes -: Sequential role of glucocorticoid receptor and pregnane X receptor
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EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
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NATURE GENETICS (2001)
Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes:: A study using adenovirus-mediated antisense targeting
R Jover et al.
HEPATOLOGY (2001)
Genomic organization of the human CYP3A locus:: identification of a new, inducible CYP3A gene
K Gellner et al.
PHARMACOGENETICS (2001)
cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450
TL Domanski et al.
MOLECULAR PHARMACOLOGY (2001)
Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7
G Bertilsson et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR
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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2001)
Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR
W Xie et al.
GENES & DEVELOPMENT (2000)
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
LB Moore et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release
DH Munzenmaier et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)
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