期刊
NPJ PRECISION ONCOLOGY
卷 6, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41698-022-00303-6
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资金
- American Society for Clinical Oncology (ASCO) Conquer Cancer Foundation Young Investigator Award
By applying an Evolutionary Action Score (EAp53) to functionally characterize TP53 mutations in TNBC patients, this study found that EAp53 stratification may identify TP53 mutations associated with worse outcomes, indicating potential for enhanced clinical management.
Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.
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