期刊
BIOACTIVE MATERIALS
卷 16, 期 -, 页码 1-11出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.02.029
关键词
Polymersomes; STING agonists; Cyclic dinucleotide; Immunotherapy; Radiotherapy
资金
- National Natural Science Foundation of China [NSFC 52033006, 51861145310, 51773146, 51633005]
- National Key R&D Program of China [2021YFB3800900]
Research has found that reduction-responsive biodegradable chimaeric polymersomes (CPs) can enhance tumor retention and cytosolic delivery of synthetic CDN, leading to improved activation of the STING pathway in the tumor microenvironment and better tumor repression and survival.
Cyclic dinucleotides (CDNs) as stimulator of interferon genes (STING) agonists capable of inducing strong antitumor innate immune response are highly promising for tumor immunotherapy. The efficacy of these CDNs is, however, reduced greatly by their fast clearance, poor cell uptake and inefficient cytosolic transportation. Here, we report that reduction-responsive biodegradable chimaeric polymersomes (CPs) markedly enhance tumor retention and cytosolic delivery of a synthetic CDN, ADU-5100, and bolster STING pathway activation in the tumor microenvironment and tumor draining lymph nodes, giving significantly better tumor repression and survival of B16F10 melanoma-bearing mice compared with free CDN control. The superiority of CPs-mediated CDN delivery is further verified in combination therapy with low-dose fractionated radiation, which brings about clearly stronger and longer-term immunotherapeutic effects and protection against tumor re-challenge. The development of nano-STING agonists that are able to overcome the delivery barriers of CDNs represents an effective strategy to potentiate cancer immunotherapy.
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