期刊
FRONTIERS IN VETERINARY SCIENCE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2022.937745
关键词
traditional Chinese medicine; piglet; antioxidant capability; inflammation; liver
资金
- Major Research and Development Projects of Jiangxi Province [20194ABC28008]
- (Inner Mongolia, China)
This study identified the effects of Xiao-Jian-Zhong-Tang (XJZT) and Jingsananli-sepsis (JJS) on oxidative stress and inflammation in the liver of piglets. The results showed that these traditional Chinese medicine prescriptions enhanced the antioxidant and anti-inflammatory capabilities of the liver through the Nrf2/NF-κB pathway, indicating their potential as functional treatments.
Oxidative stress and inflammation seriously affected the growth and development of piglets. Traditional Chinese medicine (TCM) prescriptions has been used to prevent various diseases of piglets, including anti-inflammatory and antioxidant. Here, we identified the effects of Xiao-Jian-Zhong-Tang (XJZT) and Jingsananli-sepsis (JJS) on the oxidative stress and inflammatory in the liver of piglets. The piglets were fed with the basal diet (Control group), basal diet affixed with 10 g/kg XJZT (TCM I group), and basal diet affixed with 3 g/kg JJS (TCM II group), respectively. The serum was gathered on days 30 and 60 and the liver samples were also collected on day 60. Results showed that the TCM I and TCM II markedly increased the activities of the glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC), and reduced the levels of malonaldehyde (MDA), TNF-alpha, IL-6, and IL-8 in serum. In addition, compared to the control group, Nrf2, SOD-1, NQO-1, and HO-1 mRNA expression levels and the protein levels of Nrf2 and HO-1 were significantly increased while NF-kappa B, TNF-alpha, IL-6, and IL-8 mRNA expression levels and the phosphorylation levels of NF-kappa B and I kappa B-alpha were decreased in TCM I and TCM II groups. Collectively, these findings suggested that TCM I and TCM II could enhance anti-oxidative and anti-inflammatory capabilities in the liver of piglets via the Nrf2/NF-kappa B pathway, providing a basis for the functional exploration of TCM prescriptions.
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