期刊
DIAGNOSTICS
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics12102499
关键词
peripheral artery disease; risk factors; prognosis; mortality risk; prognostic index; atherosclerosis
Atherosclerosis is the underlying cause of cardiovascular complications in patients with peripheral artery disease (PAD). This study identified hypertension, dyslipidemia, diabetes mellitus, and smoking as important factors associated with unfavorable prognosis. Patients in the high-intermediate and high-risk mortality group had higher lipid levels and fasting blood glucose levels, which correlated positively with the ankle-brachial index value.
Atherosclerosis is the basis of the cardiovascular continuum in peripheral artery disease (PAD) patients. Limiting functional decline and increasing quality of life are the main objectives for these patients. We conducted a prospective cohort study on 101 patients with PAD admitted to a single center in Northeast Romania. We used an index score to evaluate the 10-year mortality risk assessment and based on the scores we divided the patients into two groups: a low and low-intermediate risk mortality group (49 cases, 48.5%) and a high-intermediate and high-risk mortality group (52 cases, 51.5%). We analyzed demographics, comorbidities, clinical and paraclinical parameters and we aimed to identify the parameters associated with an unfavorable prognosis. Patients in the high-intermediate and high-risk mortality group were associated more with cardiovascular risk factors. Hypertension (p = 0.046), dyslipidemia (p < 0.001), diabetes mellitus (p < 0.001), and tobacco use (p = 0.018) were statistically significant factors. Lipid profile (low-density lipoprotein cholesterol, p = 0.005) and fasting blood glucose (p = 0.013) had higher mean serum values in the high-intermediate and high-risk mortality group, with a positive correlation between them and the ankle-brachial index value (p = 0.003). A multidisciplinary assessment and, especially, correction of associated cardiovascular risk factors prevent complications, and thus, improve the prognosis in the medium and long term.
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