4.6 Article

Heart Rate Variability and Salivary Biomarkers Differences between Fibromyalgia and Healthy Participants after an Exercise Fatigue Protocol: An Experimental Study

期刊

DIAGNOSTICS
卷 12, 期 9, 页码 -

出版社

MDPI
DOI: 10.3390/diagnostics12092220

关键词

autonomic modulation; physical exercise; fatigue; sympathetic nervous system

资金

  1. UEvora-UniverCIDADE VII program
  2. Portuguese Institute for Sport and Youth-I.P., Support for Sport Activity 2022, Sport Development Program [CP/217/DDT/2022]
  3. Universities Ministry of Spain and the European Union (NextGenerationUE) Ayuda del Programa de Recualificacion del Sistema Universitario Espanol, Modalidad de ayudas Margarita Salas para la formacion de jovenes doctores [MS-03]

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This study aimed to investigate the differences in heart rate variability (HRV) and salivary parameters between people with Fibromyalgia (FM) and healthy controls. The results showed significant differences in HRV and salivary biomarkers between the two groups. While people with FM did not significantly react to exercise in terms of HRV, significant differences were observed in the HRV of healthy controls after exercise.
Previous studies showed that people with Fibromyalgia (FM) suffer from dysautonomia. Dysautonomia consists of persistent autonomic nervous system hyperactivity at rest and hyporeactivity during stressful situations. There is evidence that parameters reflecting the complex interplay between the autonomic nervous system and the cardiovascular system during exercise can provide significant prognostic information. Therefore, this study aimed to investigate the differences between people with FM and healthy controls on heart rate variability (HRV) and salivary parameters (such as flow, protein concentration, enzymatic activities of amylase, catalase and glutathione peroxidase) in two moments: (1) at baseline, and (2) after an exercise fatigue protocol. A total of 37 participants, twenty-one were people with fibromyalgia and sixteen were healthy controls, participated in this cross-sectional study. HRV and salivary samples were collected before and after an exercise fatigue protocol. The fatigue protocol consisted of 20 repetitions of knee extensions and flexions of the dominant leg at 180 degrees center dot s(-1) (degrees per second). Significant differences were found in the HRV (stress index, LF and HF variables) and salivary biomarkers (with a higher concentration of salivary amylase in people with FM compared to healthy controls). Exercise acute effects on HRV showed that people with FM did not significantly react to exercise. However, significant differences between baseline and post-exercise on HRV significantly induce alteration on the HRV of healthy controls. Catalase significantly increased after exercise in healthy controls whereas salivary flow significantly increased in women with FM after an exercise fatigue protocol. Our study suggests that a higher alpha-amylase activity and an impaired HRV can be used as possible biomarkers of fibromyalgia, associated with a reduction in salivary flow without changes in HRV and catalase activity after a fatigue exercise protocol. More studies should be carried out in the future to evaluate this hypothesis, in order to find diagnostic biomarkers in fibromyalgia.

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