期刊
DIAGNOSTICS
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics12092198
关键词
ischemia; early PI; post-decompression; rat models; CRTT
资金
- Japan Society for the Promotion of Science (JSPS) [21H03269]
Persistent ischemia caused by thrombi is identified as an important cause of early pressure injury deterioration post-decompression. The capillary refill time test coupled with the transparent disc method may become a promising technique for detecting ischemia post-decompression.
Background: Pressure injuries (PIs) generally result from prolonged ischemia through localized skin compression, and ischemia persists and exacerbates damage even post-decompression. The mechanisms of ischemia post-decompression are still unclear, and appropriate methods for detection are lacking. Methods: We used blanchable erythema (BE) and early PI rat models. We assessed the perfusion using Evans Blue (EB) and thrombus formation under a light microscope. Furthermore, we performed a capillary refill time test (CRTT) to detect ischemia after depression coupled with the transparent disk method using a spectrophotometer. Results: Compared with the BE group, the early PI group showed significantly slow and insufficient perfusion, as determined by EB staining (p < 0.001). Histological observations revealed that ischemia during post-decompression of early PI was caused by a greater amount of thrombi. The CRTT results showed that although both groups exhibited varying degrees of insufficient refilling volume, the early PI group had significantly slower refilling than the BE group (p < 0.001), which persisted during the deterioration or disappearance of erythema. Conclusions: Our results showed that persistent ischemia caused by thrombi is an important cause of early PI deterioration post-decompression. Therefore, the performance of CRTT coupled with the transparent disc method may become a promising method for detecting ischemia post-decompression.
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