4.6 Article

Molecular Characterization by Whole-Genome Sequencing of Clinical and Environmental Serratia marcescens Strains Isolated during an Outbreak in a Neonatal Intensive Care Unit (NICU)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Resistome and Virulome of Multi-Drug Resistant E. coli ST131 Isolated from Residents of Long-Term Care Facilities in the Northern Italian Region

Sabrina Cherubini et al.

Summary: In this study, E. coli strains collected from LTCF residents in Northern Italy were characterized. The most common lineage found was ST131, followed by sporadic presence of other lineages. All strains were carriers of multiple virulence factors. The ST131 isolates were mainly associated with different plasmids and mutations. ST131 serves as a reservoir for the spread of extended-spectrum beta-lactamase genes in LTCF residents and also incubates fluoroquinolone, aminoglycoside, and other antibiotic resistance genes.

DIAGNOSTICS (2022)

Article Genetics & Heredity

Comprehensive pan-genomic, resistome and virulome analysis of clinical OXA-48 producing carbapenem-resistant Serratia marcescens strains

Negin Bolourchi et al.

Summary: The study focused on the antimicrobial resistance and pathogenic genes of Serratia marcescens, with four carbapenem-resistant S. marcescens isolates analyzed through whole genome sequencing. The presence of important 13-β-lactamases in conjugative plasmids highlights the role of different mobile genetic elements in the distribution of antimicrobial resistance factors.
Article Infectious Diseases

Whole-Genome Sequencing of ST2 A. baumannii Causing Bloodstream Infections in COVID-19 Patients

Sabrina Cherubini et al.

Summary: This study analyzed the antimicrobial susceptibility of 43 strains of A. baumannii isolated from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and bacterial sepsis. The strains were found to be resistant to multiple classes of antibiotics, including carbapenems and colistin. Whole-genome sequencing revealed the presence of various insertion sequences, which enhance the ability of A. baumannii to acquire and transfer antibiotic resistance genes. The bacteria also showed the presence of virulence factors and belonged to the sequence type 2 international clone.

ANTIBIOTICS-BASEL (2022)

Article Infectious Diseases

Characterization of carbapenemase-producing Serratia marcescens and whole-genome sequencing for plasmid typing in a hospital in Madrid, Spain (2016-18)

Blanca Perez-Viso et al.

Summary: The study characterized carbapenemase-producing Serratia marcescens (CPSm) isolates in a Madrid hospital, identifying two prevalent clones in both ICU and non-ICU environments. Plasmid characterization revealed that almost all CPSm carried similar plasmids, highlighting the relevance of species other than Klebsiella pneumoniae or Escherichia coli in CPE epidemiology.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Article Public, Environmental & Occupational Health

Serratia marcescens outbreak in a neonatal intensive care unit and the potential of whole-genome sequencing

A. Muyldermans et al.

Summary: Analysis of a Serratia marcescens outbreak in an NICU from 2018-2019 revealed that replacing siphons and weekly decontamination with acetic acid were key infection control measures. Whole-genome sequencing (WGS) enabled faster recognition and accurate mapping of the outbreak, facilitating the implementation of control measures. Additionally, WGS provided valuable insights into the spread of antibiotic resistance and virulence genes.

JOURNAL OF HOSPITAL INFECTION (2021)

Article Microbiology

Three challenging cases of infections by multidrug-resistant Serratia marcescens in patients admitted to intensive care units

Kesia Esther da Silva et al.

Summary: The study reports three cases of carbapenem-resistant S. marcescens infections with unfavorable clinical outcomes. Through whole-genome sequencing, multiple genes related to resistance and virulence were identified. These cases highlight the serious infection caused by multidrug-resistant organisms and the complexity of treatment.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Biology

Characterization of Haemophilus influenzae Strains with Non-Enzymatic Resistance to β-Lactam Antibiotics Caused by Mutations in the PBP3 Gene in the Czech Republic in 2010-2018

Vladislav Jakubu et al.

Summary: Surveillance data in the Czech Republic have shown an increasing trend in strains of Haemophilus influenzae with non-enzymatic resistance to beta-lactam antibiotics, particularly due to mutations in the ftsI gene. The most common amino acid substitution combination detected in the PBP3 protein was D350N, M377I, A502V, N526K. Epidemiological typing did not suggest clonal spread of a specific MLST type, indicating a diverse genetic profile among the detected strains.

LIFE-BASEL (2021)

Letter Infectious Diseases

First report of carbapenemase OXA-181-producing Serratia marcescens

Aziza Messaoudi et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

Article Microbiology

Whole-Genome Sequencing (WGS) of Carbapenem-Resistant K. pneumoniae Isolated in Long-Term Care Facilities in the Northern Italian Region

Alessandra Piccirilli et al.

Summary: This study identified thirteen K. pneumoniae lineages spreading among long-term care facilities in Northern Italy, with the prevalence of ST307, ST512, and ST37 as major lineages. The most widespread resistance genes in these facilities were bla(KPC-2), bla(KPC-3), bla(KPC-9), bla(SHV-11), bla(SHV-28), bla(CTX-M-15), bla(OXA-1), bla(OXA-9), bla(OXA-23), qnrS1, qnrB19, qnrB66, aac(6 ')-Ib-cr, and fosA. Additionally, KPC carbapenemases were found to be the most common beta-lactamases.

MICROORGANISMS (2021)

Article Microbiology

A Standard Numbering Scheme for Class C β-Lactamases

Andrew R. Mack et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Public, Environmental & Occupational Health

Serratia marcescens in the neonatal intensive care unit: A cluster investigation using molecular methods

Kee T. Yeo et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

Review Environmental Sciences

Serratia marcescens Infections in Neonatal Intensive Care Units (NICUs)

Maria Luisa Cristina et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

Article Public, Environmental & Occupational Health

Serratia marcescens colonization in preterm neonates during their neonatal intensive care unit stay

Laura Moles et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2019)

Article Microbiology

Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems

Carlo Bottoni et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Article Infectious Diseases

Preterm infant gut colonization in the neonatal ICU and complete restoration 2 years later

L. Moles et al.

CLINICAL MICROBIOLOGY AND INFECTION (2015)

Review Microbiology

Regulation of Bacterial Virulence by Csr (Rsm) Systems

Christopher A. Vakulskas et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2015)

Article Evolutionary Biology

Genome Evolution and Plasticity of Serratia marcescens, an Important Multidrug-Resistant Nosocomial Pathogen

Atsushi Iguchi et al.

GENOME BIOLOGY AND EVOLUTION (2014)

Article Multidisciplinary Sciences

The Long-Term Stability of the Human Gut Microbiota

Jeremiah J. Faith et al.

SCIENCE (2013)

Review Neurosciences

The immune consequences of preterrn birth

Jacqueline M. Melville et al.

FRONTIERS IN NEUROSCIENCE (2013)

Review Microbiology

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

Lucia Fernandez et al.

CLINICAL MICROBIOLOGY REVIEWS (2012)

Article Public, Environmental & Occupational Health

Outbreaks of Serratia marcescens in neonatal and pediatric intensive care units: Clinical aspects, risk factors and management

Alexander Voelz et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2010)

Article Pediatrics

Serratia marcescens sepsis outbreak in a neonatal intensive care unit

Ugur Arslan et al.

PEDIATRICS INTERNATIONAL (2010)

Article Public, Environmental & Occupational Health

Investigation of an outbreak of Serratia marcescens in a neonatal unit via a case-control study and molecular typing

N. Deborah Friedman et al.

AMERICAN JOURNAL OF INFECTION CONTROL (2008)

Article Public, Environmental & Occupational Health

An outbreak of Serratia marcescens septicaemia in neonatal intensive care unit in Gaza City, Palestine

A. M. Kh. Al Jarousha et al.

JOURNAL OF HOSPITAL INFECTION (2008)

Review Microbiology

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

Eric Sauvage et al.

FEMS MICROBIOLOGY REVIEWS (2008)

Article Biotechnology & Applied Microbiology

Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens

Stuart A. Thompson et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Article Public, Environmental & Occupational Health

Outbreak of Serratia marcescens colonization and infection traced to a Healthcare worker with long-term carriage on the hands

Jutte J. C. de Vries et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2006)

Article Public, Environmental & Occupational Health

An outbreak of Serratia marcescens on the neonatal unit:: a tale of two clones

MD David et al.

JOURNAL OF HOSPITAL INFECTION (2006)

Article Public, Environmental & Occupational Health

A simultaneous outbreak of Serratia marcescens and Klebsiella pneumoniae in a neonatal intensive care unit

C Casolari et al.

JOURNAL OF HOSPITAL INFECTION (2005)

Article Microbiology

Extended epidemic of nosocomial urinary tract infections caused by Serratia marcescens

LH Su et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2003)