Introduction of Flavor Chemical Eugenol Attenuating the Synergistic Toxicological Interactions of Flavor Mixtures

Article Environmental Sciences

Eugenol mitigated acute lung but not spermatic toxicity of C60 fullerene emulsion in mice

Felipe Gomes Pinheiro et al.

Summary: Exposure to C-60 emulsion deteriorates lung morphofunctional, redox, and inflammatory characteristics, increasing the risk of infertility. Eugenol can avoid these changes, but does not prevent sperm damage.

ENVIRONMENTAL POLLUTION (2021)

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Article Environmental Sciences

Combined lethal toxicities of pesticides with similar structures to Caenorhabditis elegans are not necessarily concentration additives

Peng Huang et al.

Summary: This study investigated the mixture toxicity of pesticides with similar chemical structures and found that the interaction types of different types of pesticide mixtures varied, with some showing antagonistic effects and others showing synergistic effects. The structural similarity of pesticides was found to have a quantitative relationship with the toxicity interaction of mixtures, indicating that within a certain range, the structural similarity of the same type of pesticides may exhibit additive action.

ENVIRONMENTAL POLLUTION (2021)

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Article Biochemistry & Molecular Biology

Amino Alcohols from Eugenol as Potential Semisynthetic Insecticides: Chemical, Biological, and Computational Insights

Renato B. Pereira et al.

Summary: A series of beta-amino alcohols were synthesized by reacting eugenol epoxide with aliphatic and aromatic amine nucleophiles and evaluated for their insecticidal potential. Three derivatives were identified as the most potent, and further studies suggest they may target acetylcholinesterase and/or insect odorant-binding proteins. Encapsulation assays showed high efficiency for the most active compound, and a thermosensitive formulation was achieved for more efficient compound release at higher temperatures.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Anticancer Properties of Eugenol: A Review

Ali T. Zari et al.

Summary: Eugenol, the principal active component of clove, exhibits anticancer, antioxidant, anti-inflammatory, and antimicrobial properties. It shows promising effects in inducing cell death, cell cycle arrest, and inhibiting migration, metastasis, and angiogenesis in various cancer cell lines. Additionally, when used as an adjunct therapy to conventional chemotherapy, eugenol enhances effectiveness while reducing toxicity, making it a valuable candidate for cancer treatment.

MOLECULES (2021)

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Article Environmental Sciences

Assessing the combined toxicity of carbamate mixtures as well as organophosphorus mixtures to Caenorhabditis elegans using the locomotion behaviors as endpoints

Yu Wang et al.

Summary: This study systematically evaluated the locomotion behavioral toxicities of carbamate pesticides (CMs) and organophosphorus pesticides (OPs) on Caenorhabditis elegans, and found that they produce significant inhibitory effects on the locomotion behavior of the nematodes, with OPs showing higher toxicity than CMs. Toxicological interactions in the binary CM and OP mixtures were found to be different from each other, highlighting the importance of examining multiple concentration ratios rather than relying on just one.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Chemistry, Multidisciplinary

Study on the Combined Toxicities and Quantitative Characterization of Toxicity Sensitivities of Three Flavor Chemicals and Their Mixtures to Caenorhabditis elegans

Sheng Lu et al.

Summary: This study demonstrated that certain flavor chemicals and their mixture rays have high toxicity sensitivities to Caenorhabditis elegans (C. elegans), which could potentially impact human health. The three flavor chemicals showed significant concentration-response relationships on the lethality of C. elegans, with high toxicity sensitivity. In mixture systems, the toxicity sensitivities of mixture rays with different mixture ratios varied at different exposure volumes, showing complex toxicological interactions.

ACS OMEGA (2021)

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Article Medicine, Research & Experimental

Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats

Abhishek Kumar et al.

Summary: The study showed that eugenol has a strong protective effect against liver damage induced by cadmium, including reversing oxidative stress and inflammation. In the experiment, eugenol effectively restored the biochemical alterations caused by Cd.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Chemistry, Multidisciplinary

The Effect of Eugenol and Chitosan Concentration on the Encapsulation of Eugenol Using Whey Protein-Maltodextrin Conjugates

Iceu Agustinisari et al.

APPLIED SCIENCES-BASEL (2020)

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Article Environmental Sciences

Genetically modified Caenorhabditis elegans may lead to inaccurate toxicity evaluation of mixtures

Peng Huang et al.

ENVIRONMENTAL SCIENCES EUROPE (2020)

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Article Environmental Sciences

Intergenerational toxicity of nonylphenol ethoxylate (NP-9) in Caenorhabditis elegans

Ana De la Parra-Guerra et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Article Biochemistry & Molecular Biology

New Eugenol Derivatives with Enhanced Insecticidal Activity

Maria Jose G. Fernandes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Environmental Sciences

Toxicological implications of amplifying the antibacterial activity of gallic acid by immobilisation on silica particles: A study on C. elegans

Samuel Verdu et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020)

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Article Chemistry, Analytical

Quantitative evaluation and the toxicity mechanism of synergism within three organophosphorus pesticide mixtures toChlorella pyrenoidosa

Meng-ting Tao et al.

ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2020)

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Article Multidisciplinary Sciences

Simultaneous detection of five flavoring agents in chewing gum by ultrasound-microwave synergistic extraction coupled with gas chromatography

Junde Li et al.

SCIENTIFIC REPORTS (2019)

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Article Environmental Sciences

Mixture Effects of Copper, Cadmium, and Zinc on Mortality and Behavior of Caenorhabditis elegans

Sofie Moyson et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

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Article Oncology

Tumor suppressive roles of eugenol in human lung cancer cells

Li Fangjun et al.

THORACIC CANCER (2018)

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Article Chemistry, Multidisciplinary

Time-dependent and Pb-dependent antagonism and synergism towards Vibrio qinghaiensis sp.-Q67 within heavy metal mixtures

Jin Zhang et al.

RSC ADVANCES (2018)

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Article Engineering, Environmental

The time-dependent synergism of the six-component mixtures of substituted phenols, pesticides and ionic liquids to Caenorhabditis elegans

Li Feng et al.

JOURNAL OF HAZARDOUS MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Polymyxin B sulfate inducing time-dependent antagonism of the mixtures of pesticide, ionic liquids, and antibiotics to Vibrio qinghaiensis sp.-Q67

Ye Fan et al.

RSC ADVANCES (2017)

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Article Multidisciplinary Sciences

Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase

Rana Al Wafai et al.

SCIENTIFIC REPORTS (2017)

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Article Agronomy

Evaluation of eugenol toxicity in bioassays with test-organisms

Juliano Santos Gueretz et al.

CIENCIA RURAL (2017)

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Article Environmental Sciences

Global concentration additivity and prediction of mixture toxicities, taking nitrobenzene derivatives as an example

Tong Li et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2017)

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Review Pharmacology & Pharmacy

Pharmacological and Toxicological Properties of Eugenol

Solmaz Mohammadi Nejad et al.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Chemistry, Analytical

Combining the uniform design-based ray procedure with combination index to investigate synergistic lethal toxicities of ternary mixtures on Caenorhabditis elegans

Han-Xiao Tang et al.

ANALYTICAL METHODS (2016)

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Article Multidisciplinary Sciences

Uniform design ray in the assessment of combined toxicities of multi-component mixtures

Shu-Shen Liu et al.

SCIENCE BULLETIN (2016)

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Article Chemistry, Applied

Transitioning to nontoxic antifouling paints

Monica Garcia et al.

PIGMENT & RESIN TECHNOLOGY (2015)

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Article Oncology

Survival of lung cancer patients in a resource-limited country

Soon Hin How et al.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Environmental Sciences

Identifying the component responsible for antagonism within ionic liquid mixtures using the up-to-down procedure integrated with a uniform design ray method

Jin Zhang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2014)

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Article Chemistry, Multidisciplinary

APTox: Assessment and Prediction on Toxicity of Chemical Mixtures

Liu Shushen et al.

ACTA CHIMICA SINICA (2012)

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Article Pharmacology & Pharmacy

Anti-arthritic Effect of Eugenol on Collagen-Induced Arthritis Experimental Model

Renata Grespan et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2012)

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Article Food Science & Technology

A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats

Jianyong Li et al.

FOOD AND CHEMICAL TOXICOLOGY (2012)

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Review Biochemistry & Molecular Biology

Eugenol-From the Remote Maluku Islands to the International Market Place: A Review of a Remarkable and Versatile Molecule

Guy P. Kamatou et al.

MOLECULES (2012)

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Article Biotechnology & Applied Microbiology

Eugenol Reduces the Expression of Virulence-Related Exoproteins in Staphylococcus aureus

Jiazhang Qiu et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)

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Article Plant Sciences

Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane

K. Pandima Devi et al.

JOURNAL OF ETHNOPHARMACOLOGY (2010)

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Article Medicine, General & Internal

Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer

Scott A. Waldman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

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Article Plant Sciences

Synergistic interaction of eugenol with antibiotics against Gram negative bacteria

S. Hemaiswarya et al.

PHYTOMEDICINE (2009)

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Article Biochemistry & Molecular Biology

Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells:: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase

Eun Hee Han et al.

FEBS LETTERS (2007)

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Article Biochemistry & Molecular Biology

WormBook: the online review of Caenorhabditis elegans biology

Lisa R. Girard et al.

NUCLEIC ACIDS RESEARCH (2007)

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Article Dentistry, Oral Surgery & Medicine

Mechanisms of cytotoxicity of eugenol in human osteoblastic cells in vitro

YC Ho et al.

INTERNATIONAL ENDODONTIC JOURNAL (2006)

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Article Toxicology

A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions

T Atsumi et al.

TOXICOLOGY IN VITRO (2005)

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Article Biochemistry & Molecular Biology

Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity

R Ghosh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Introduction of Flavor Chemical Eugenol Attenuating the Synergistic Toxicological Interactions of Flavor Mixtures

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