相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。An integrated multi-omics approach revealed the regulation of melatonin on age-dependent mitochondrial function impair and lipid dyshomeostasis in mice hippocampus
Xiaowen Jiang et al.
PHARMACOLOGICAL RESEARCH (2022)
Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression
Maria-Angeles Cortes-Gomez et al.
JOURNAL OF NEUROCHEMISTRY (2021)
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease
Wenwu Liu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer's Disease
Marta Campora et al.
PHARMACEUTICALS (2021)
The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease
Immacolata Vecchio et al.
JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE (2021)
Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology
Xiao-wen Jiang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2020)
Jiang Gui Fang activated interscapular brown adipose tissue and induced epididymal white adipose tissue browning through the PPARγ/SIRT1-PGC1α pathway
Yu-xin Zu et al.
JOURNAL OF ETHNOPHARMACOLOGY (2020)
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade
Fang Zhang et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology
Xiaowen Jiang et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2020)
Amyloid burden assessed by three amyloid PET tracers in the elenbecestat MissionAD Phase 3 program
Claire Roberts et al.
Alzheimers & Dementia (2020)
BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain
Cyrille Sur et al.
BRAIN (2020)
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease
Piyoosh Sharma et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Safety, Tolerability, and Pharmacokinetics of the β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Verubecestat (MK-8931) in Healthy Elderly Male and Female Subjects
Mark Forman et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2019)
Identification of New Potent Human Uncoupling Protein 1 (UCP1) Agonists Using Virtual Screening and In Vitro Approaches
Hong-Yuan Lu et al.
MOLECULAR INFORMATICS (2019)
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease
Berenice Hatat et al.
FRONTIERS IN AGING NEUROSCIENCE (2019)
Structural insights into the binding mode of flavonols with the active site of matrix metalloproteinase-9 through molecular docking and molecular dynamic simulations studies
Dhinakararajan Pradiba et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2018)
Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review
Angela Rampa et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)
An Overview on the Clinical Development of Tau-Based Therapeutics
Miguel Medina
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid A Peptides
Kei Sakamoto et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2017)
Molecular modeling-driven approach for identification of Janus kinase 1 inhibitors through 3D-QSAR, docking and molecular dynamics simulations
Ramesh Itteboina et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2017)
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease
Sai-Sai Xie et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
A combination of pharmacophore modeling, atom-based 3D-QSAR, molecular docking and molecular dynamics simulation studies on PDE4 enzyme inhibitors
Naga Srinivas Tripuraneni et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2016)
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors
Rita Maria Concetta Di Martino et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
The road to restoring neural circuits for the treatment of Alzheimer's disease
Rebecca G. Canter et al.
NATURE (2016)
Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors
Agnieszka A. Kaczor et al.
JOURNAL OF MOLECULAR MODELING (2015)
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors
Federica Prati et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments
Margaret K. King et al.
PHARMACOLOGY & THERAPEUTICS (2014)
Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4
EC Row et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2006)